Decreased frontal and orbital volumes and increased cerebellar volumes in patients with anosmia Of Unknown origin: A subtle connection?

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dc.authorid0000-0002-2306-5937
dc.contributor.authorAvnioglu, Seda
dc.contributor.authorSahin, Caner
dc.contributor.authorCankaya, Seyda
dc.contributor.authorOzen, Ozkan
dc.contributor.authorDikici, Rumeysa
dc.contributor.authorYilmaz, Halil
dc.contributor.authorVelioglu, Halil Aziz
dc.date.accessioned2026-01-24T12:31:16Z
dc.date.available2026-01-24T12:31:16Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractPurpose: Neuroimaging studies have shown that anosmia is accompanied by a decreased olfactory bulb volume, yet little is known about alterations in cerebral and cerebellar lobule volumes. The purpose of this study was to investigate structural brain alterations in anosmic patients.Methods: Sixteen anosmic patients (mean age 42.62 +/- 16.57 years; 6 women and 10 men) and 16 healthy controls (mean age 43.37 +/- 18.98 years; 9 women and 7 men) were included in this retrospective study. All subjects who underwent magnetic resonance imaging scans were analyzed using VolBrain and voxel-based morphometry after olfactory testing.Results: Despite being statistically insignificant, analysis using VBM revealed greater gray matter (GM) and white matter in the anosmia group compared to the healthy subjects. However, decreased GM (p < 0.001) and increased cerebellar (p = 0.046) volumes were observed in the anosmic patients.Conclusions: The study revealed structural brain alterations in specific areas beyond the olfactory bulb. Our re-sults indicate that the cerebellum may play an exceptional role in the olfactory process and that this will be worth evaluating with further dynamic neuroimaging studies.
dc.identifier.doi10.1016/j.jpsychires.2023.01.015
dc.identifier.endpage92
dc.identifier.issn0022-3956
dc.identifier.issn1879-1379
dc.identifier.pmid36791532
dc.identifier.scopus2-s2.0-85148768234
dc.identifier.scopusqualityQ1
dc.identifier.startpage86
dc.identifier.urihttps://doi.org/10.1016/j.jpsychires.2023.01.015
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5752
dc.identifier.volume160
dc.identifier.wosWOS:000944371800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofJournal of Psychiatric Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectAnosmia
dc.subjectBrain volume
dc.subjectVBM
dc.subjectVolBrain
dc.subjectMRI
dc.titleDecreased frontal and orbital volumes and increased cerebellar volumes in patients with anosmia Of Unknown origin: A subtle connection?
dc.typeArticle

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