Decreased frontal and orbital volumes and increased cerebellar volumes in patients with anosmia Of Unknown origin: A subtle connection?
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Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: Neuroimaging studies have shown that anosmia is accompanied by a decreased olfactory bulb volume, yet little is known about alterations in cerebral and cerebellar lobule volumes. The purpose of this study was to investigate structural brain alterations in anosmic patients.Methods: Sixteen anosmic patients (mean age 42.62 +/- 16.57 years; 6 women and 10 men) and 16 healthy controls (mean age 43.37 +/- 18.98 years; 9 women and 7 men) were included in this retrospective study. All subjects who underwent magnetic resonance imaging scans were analyzed using VolBrain and voxel-based morphometry after olfactory testing.Results: Despite being statistically insignificant, analysis using VBM revealed greater gray matter (GM) and white matter in the anosmia group compared to the healthy subjects. However, decreased GM (p < 0.001) and increased cerebellar (p = 0.046) volumes were observed in the anosmic patients.Conclusions: The study revealed structural brain alterations in specific areas beyond the olfactory bulb. Our re-sults indicate that the cerebellum may play an exceptional role in the olfactory process and that this will be worth evaluating with further dynamic neuroimaging studies.
Açıklama
Anahtar Kelimeler
Anosmia, Brain volume, VBM, VolBrain, MRI
Kaynak
Journal of Psychiatric Research
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
160
