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https://hdl.handle.net/20.500.12868/8

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Investigating spectroscopic measurement of sublingual veins and tissue to estimate central venous oxygen saturation
(2022) Sırcan Küçüksayan, Aslınur; Eray, Oktay; Büyükaksu, Murat; Gümüş, Birce; Dursun, Oğuz; Canpolat, Murat
Abstract: BACKGROUND: Venous oxygen saturation reflects venous oxygenation status and can be used to assess treatment and prognosis in critically ill patients. A novel method that can measure central venous oxygen saturation (ScvO2) non-invasively may be beneficial and has the potential to change the management routine of critically ill patients. OBJECTIVE: The study aims to evaluate the potential of sublingual venous oxygen saturation (SsvO2) to be used in the estimation of ScvO2. METHODS: We have developed two different approaches to calculate SsvO2. In the first one, near-infrared spectroscopy (NIRS) measurements were performed directly on the sublingual veins. In the second approach, NIRS spectra were acquired from the sublingual tissue apart from the sublingual veins, and arterial oxygen saturation was measured using a pulse oximeter on the fingertip. RESULTS: Twenty-six healthy subjects were included in the study. In the first and second approaches, average SsvO2 values were 75.0% ± 1.8 and 75.8% ± 2.1, respectively. The results of the two different approaches were close to each other and similar to ScvO2 of healthy persons (> 70%). CONCLUSION: Oxygen saturation of sublingual veins has the potential to be used in intensive care units, non-invasively and in real-time, to estimate ScvO2.
Ocular surface microbiota changes after external dacryocystorhinostomy: a “chicken or egg” problem
(2020) Aslan, Fatih; Doğan, Bora; Şahin, Caner
Objective: The aim of this study was to evaluate changes in the ocular surface and nasal microbiota after external dacryocystorhinostomy (DCR) in patients with unilateral nasolacrimal duct obstruction (NLDO). Methods: This prospective study included 68 eyes of 34 patients. Prior to external DCR, nasal and conjunctival smears were obtained from the affected eye and healthy contralateral eye. Results: Ocular surface cultures were positive in 19 (55.9%) of the NLDO eyes and 4 (11.8%) of the healthy eyes (p[removed]
The effect of aging and exercise training on carbon monoxide relaxation response in thoracic aorta and gastrocnemius feed artery
(2020) Koçer, Günnur; Nasırcılar Ülker, Seher; Olgar, Yusuf; Öztürk, Nihal; Özdemir, Semir
Amaç: Bu çalışmanın amacı yaşlanma ve yüzme egzersizine bağlı olarak sıçanların torasik aortasında ve gastroknemius iletim arterinde karbon monoksit (CO)’e verilen damar yanıtlarının değişip değişmediğini test etmektir. Yöntem: Çalışmamızda 4 aylık genç ve 24 aylık yaşlı Wistar dişi sıçanlar kullanıldı. Sıçanlar rastgele gençsedanter (GS), genç-egzersiz (GE), yaşlı-sedanter (YS) ve yaşlı-egzersiz (YE) olmak üzere dört gruba ayrıldı. Egzersiz gruplarına 8 hafta süresince haftada 5 gün, günde 1 saat yüzme egzersizi yaptırıldı. Sıçanlardan izole edilen torasik aorta halkaları organ banyosu düzeneğinde, gastroknemius iletim arteri ise telli miyograf düzeneğinde çalışıldı. Aort ve gastroknemius iletim arteri halkalarının fenilefrin (PE) kasılma yanıtları hemoksijenaz inhibitörü chromium mesoporphyrin inkübasyonu öncesi ve sonrasında kaydedilerek endojen olarak üretilen CO’in vasküler tonusa katkısı değerlendirildi. CO donörü (CORM; carbon - monoxide - releasing - molecule) kullanılarak ekzojen gevşeme yanıtları değerlendirildi. Bulgular: CrMP inkübasyonu öncesinde ve sonrasında PE doz yanıt eğrilerinde hem aortada hem de gastroknemius iletim arterinde gruplar arasında fark yoktu. CrMP inkübasyonu sonrasında alınan maksimum PE kasılma yanıtları aort halkalarında GE, YS ve YE gruplarında anlamlı olarak daha yüksekti (p<0,05), gastroknemius iletim arterlerinde ise sadece GS ve GE gruplarında anlamlı olarak yüksekti (p<0,01). CORM’a verilen maksimum gevşeme yanıtlarında gastroknemius iletim arterinde gruplar arasında fark yoktu. Aorta halkalarında ise maksimum CORM gevşeme yanıtları yaşlı gruplarda anlamlı olarak daha düşüktü (p<0,05). Sonuç: Çalışmanın sonuçları; gastroknemius iletim arterinde CO yanıtlarına egzersiz ve yaşlanmanın etkisi olmadığını, Aorta halkalarında ise CO gevşeme yanıtının yaşlanmayla birlikte azaldığını ve egzersizin CO gevşeme yanıtını hem yaşlı hem de genç sıçanlarda arttırıcı bir katkısının olmadığını göstermektedir.
Carbon monoxide contributes to the regulation of vascular tonus in renal resistance arteries in spontaneously hypertensive rats
(2020) Koçer, Günnur; Nasırcılar, Seher; Basralı, Filiz; Kuru, Oktay; Şentürk, Ümit Kemal
Objective: Carbon monoxide (CO), an end product of heme oxygenase (HO) involved in the regulation of vascular tone, may show a compensatory effect in the course of hypertension. This study aimed to assess the effects of the HO/CO system on the vascular tone of renal resistance arteries in spontaneously hypertensive rats (SHRs). Methods: The contribution of endogenous CO to vascular tone in renal resistance arteries was evaluated by the phenylephrine (Phe) contraction response with or without an HO inhibitor. The effect of the exogenous CO relaxation response was assessed by a CO releasing molecule (CORM). The mechanism of the CO relaxation effect was evaluated by a guanylate cyclase inhibitor, ODQ, or a potassium channel blocker, TEA. HO-1 and HO-2 enzyme protein expressions in renal resistance arteries were determined by Western blot analysis. Results: Phe-induced constriction responses were higher in renal resistance arteries of SHRs compared to control animals. The extent of the same type of constriction was even higher in the SHR group after inhibition of CO production. Relaxation responses to a CO donor, CORM, were greater in the SHR group versus the control group. TEA, but not ODQ, suppressed CORM responses in both groups. HO-2 protein expression patterns were not different between the groups, while HO-1 expression was remarkably higher in SHRs when compared to that in control rats. Conclusion: Consequently, our results revealed a CO-based compensatory effect in SHRs by the induction of CO production and an increase in its bioavailability.
Evaluation of patients presenting to the ophthalmology department of a tertiary hospital for nonemergency reasons during the covid-19 pandemic
(2020) Aslan, Fatih; Öktem, Çağlar
Objective: To evaluate changes in the demographic and diagnostic distribution of patients presenting to the ophthalmology department during the COVID-19 pandemic, compared to the pre-pandemic period. Methods: The study included patients who made outpatient appointments in our ophthalmology department. The COVID-19 group (CovG) comprised patients who presented between April 15 and May 15, 2020, the 30-day period with the highest daily number of new cases in Turkey. The control group (CG) was obtained by randomization through a computer program from among 2 245 patients who applied in the same period of the previous year. The patients’ presenting complaint(s), diagnostic(s) and demographic information’s were collected from a database, with all identifying information concealed. For patients who presented more than once, their initial complaint and diagnoses were analyzed. Results: The study included a total of 400 patients: 200 in the CovG and 200 in the CG. Mean ages in the CovG and CG were 41.23 ± 14.48 and 48.20 ± 17.49 years, respectively (p < 0.001). The female to male patient ratio was 0.53 in the CovG and 0.83 in the CG (p = 0.032). There were fewer university graduates compared to other education levels among the patients who presented during the pandemic (p = 0.013). During the COVID-19 pandemic, there was no increase in presentation frequency for any ocular disease compared to the previous year. The only statistical decrease in patient application complaints was observed in reading difficultness (11 % in CovG vs. 37 % in CG; p < 0.001). Presentations due to dry eye (DE) and allergic conjunctivitis (AC) were similar to the same period of the year (p = 0.303 and p = 0.550, respectively). At least 1 chronic ocular disease was present in 25 % of the CovG and 45.5 % of the CG (p < 0.001). A statistically significant decrease was observed in CovG for age-related macular degeneration and glaucoma in the diagnoses made at the end of the examination (p = 0.001 and p < 0.001, respectively). Conclusion: During the first peak of the COVID-19 pandemic in Turkey, the most common outpatient presentations to the ophthalmology department were for the diagnoses of DE and AC. During peak pandemic period, elderly patients, women and academically trained patients significantly reduced their visits to the Eye Clinic. The reduction in presentation of patients with glaucoma and age-related macular degeneration may be due to the longterm treatment planning for these patients and the social isolation measures issued for the older population. These patients should be encouraged to use video consultation / telemedicine in eye patients at risk of vision loss.
Selenium enhances TRPA1 channel-mediated activity of temozolomide in SH-SY5Y neuroblastoma cells
(2020) Özkal, Birol; Övey, İshak Suat
Purpose Neuroblastoma is a malignant solid tumor that originates from the sympathetic nervous system in early childhood. Temozolomide is used for treatment in high-risk groups with low treatment response of neuroblastomas. TRPA1 channels in neuroblastoma cells are calcium permeable channels that can be activated by reactive oxygen species (ROT). In this study, we aimed to evaluate the level of activity of temozolomide and selenium in neuroblastoma cells via TRPA1 channels. Method Seven main groups were formed using SH-SY5Y neuroblastoma cells. The control was divided into temozolomide (TMZ) (100 ?M, 24 h), TMZ+SEL+AP18, SEL (sodium selenite, 100 ?M, 24 h), and SEL+AP18 groups. Intergroup calcium signaling, intracellular reactive oxygen species, caspase-3 and caspase-9, and mitochondrial depolarization analyses were performed by channel activation with TRPA1 agonist cinnamaldehyde in all groups. Results Cytosolic calcium concentration, apoptosis, caspase-3 and caspase-9 activation, mitochondrial membrane depolarization, and ROT levels were higher in TMZ (p < 0.001), TMZ+SEL (p < 0.001), and SEL (p < 0.05) groups than the control group. TRPA1 was lower in TTMZ+AP18, TMZ+SEL+AP18, and SEL+AP18 groups with channel blockers than respectively TMZ, TMZ+SEL, and SEL groups without channel blockers (p < 0.05). Conclusion The use of selenium with temozolomide increased the apoptotic efficacy of temozolomide via TRPA1 channels on tumor cells
Unusual presentation of moyamoya disease with popliteal involvement: Case report and review of the literature
(2021) Etli, Mustafa; Karahan, Oğuz
Moyamoya disease is a rare disorder that involves the cerebrovascular system. Usually, it leads to occlusion of the arteries of the cerebral system and causes cerebral circulatory complaints. A 48-year-old female patient was admitted to our clinic with intermittent claudication in both legs. Biphasic and monophasic waveform patterns were detected bilaterally in distal (trifurcation arteries) lower extremities with Doppler sonography. The patient therefore underwent systemic vascular examination. Computed tomography angiography revealed bilateral carotid occlusion at the level of supraclinoid segments, and opacifications were detected at the distal segments of the bilateral anterior cerebellar and middle cerebellar arteries. The patient was diagnosed with moyamoya disease, and anticoagulant treatment was started. In conclusion, most previous reports have presented the cerebrovascular involvement of moyamoya disease. However, this disease can involve different peripheral vascular systems and careful and systemic vascular examination is necessary for an exact diagnosis.
Determination of learning requirements of stroke patients with type 2 diabetes in Turkey sample
(2021) Can, Gonca Şengül; Uymaz, Pelin
Objective: We aimed to investigate whether a relationship is present between early cataract formation and vitamin D in young adults. Methods: A total of 37 cataract patients (18 males and 19 females) and 53 healthy participants (27 males and 26 females) under the age of 60 years were included in this study. The 25-OH vitamin D values were measured in all subjects and the mean vitamin D levels compared between the 2 groups. Additionally, the differences between the vitamin D levels of the genders in both groups were investigated. Results: The mean age of the study group was 48.1 ± 8.5 (range 33-59) years, and the mean age of the control group was 49.3 ± 7.8 (range 31-59) years (p = 0.48 and p = 0.83). The mean vitamin D level was 15.6 ± 8.4 ng/mL in the study group and 20.8 ± 7.1 ng/mL in the healthy subjects (p = 0.002). Among the females, the vitamin D level was 10.6 ± 4.7 ng/mL in the study group and 18.1 ± 6.4 ng/mL in the control group (p = 0.0001). No significant difference was found between the groups among the males (p = 0.24). Conclusion: We found vitamin D deficiency to be associated with early age-related cataract in a statistically significant manner. We believe it is worth investigating the reason for this concurrence with large longitudinal studies.
Vitamin D Levels in Young Adult Cataract Patients: A Case-Control Study
(2021) Öktem, Çağlar; Aslan, Fatih
Objective: We aimed to investigate whether a relationship is present between early cataract formation and vitamin D in young adults. Methods: A total of 37 cataract patients (18 males and 19 females) and 53 healthy participants (27 males and 26 females) under the age of 60 years were included in this study. The 25-OH vitamin D values were measured in all subjects and the mean vitamin D levels compared between the 2 groups. Additionally, the differences between the vitamin D levels of the genders in both groups were investigated. Results: The mean age of the study group was 48.1 ± 8.5 (range 33-59) years, and the mean age of the control group was 49.3 ± 7.8 (range 31-59) years (p = 0.48 and p = 0.83). The mean vitamin D level was 15.6 ± 8.4 ng/mL in the study group and 20.8 ± 7.1 ng/mL in the healthy subjects (p = 0.002). Among the females, the vitamin D level was 10.6 ± 4.7 ng/mL in the study group and 18.1 ± 6.4 ng/mL in the control group (p = 0.0001). No significant difference was found between the groups among the males (p = 0.24). Conclusion: We found vitamin D deficiency to be associated with early age-related cataract in a statistically significant manner. We believe it is worth investigating the reason for this concurrence with large longitudinal studies. © 2020 S. Karger AG, Basel. All rights reserved.
A qualitative exploration of fear of cancer recurrence in Turkish cancer survivors who were referred for colposcopy
(2021) Üner, Fatma Özlem; Körükçü, Öznur
We aimed to qualitatively explore factors related to fear of cancer recurrence in women who had a risk of cervical cancer relapse/metastasis and to identify the psychological effect of gynaecological examination and colposcopy in cancer survivors. We conducted the present descriptive study with a qualitative design based on the thematic analysis approach on ten women who under suspicion of new cancer and were admitted to the Gynaecological Oncology Polyclinic of Akdeniz University for colposcopy between July and October 2017 via in-depth interviews. As a result of the interviews, we identified three main themes: colposcopy-related fear, emotions associated with fear of cancer recurrence, and fear of being diagnosed with cancer. Moreover it was determined that women experienced a fear of death, fear of family being affected, fear of stigmatisation by society, and fear of not coping with the treatment process. We found that women with cancer history and undergoing colposcopy because of abnormal cervical cytology in routine oncology controls experienced a significant fear of cancer recurrence. We found that gynaecological examination and colposcopy caused anxiety in patients. Healthcare professions should be aware and help women to cope with the fear of cancer recurrence in the colposcopy process and should determine the social care needs of these patients.
Plasma thiol/disulphide homeostasis changes in patients with relapsing-remitting multiple sclerosis
(2021) Özben, Serkan; Küçüksayan, Ertan; Köseoğlu, Mesrure; Erel, Özcan; Neşelioğlu, Salim; Özben, Tomris
Background: Multiple sclerosis (MS) is a neuroinflammatory disease and inflammation and oxidative stress play important roles in its pathology. Thiol/disulphide homeostasis (TDH) is a special oxidative stress biomarker that has been found to be affected in several disorders including MS. There is no study demonstrating the effects of attack status of the relapsing-remitting multiple sclerosis (RRMS) patients on TDH levels. Our aim was to determine TDH levels in three different periods of RRMS patients and healthy individuals. Methods: The study was carried out in 29 patients with RRMS without a prior attack in the last twelve months (MS Control), 21 RRMS patients having a clinical acute attack within the last week (MS relapse), 12 of 21 MS relapse patients one month after the onset of attack and following 1000 mg methylprednisolone for 7 days (MS Remission) and 30 age- and sex-matched healthy individuals. TDH status was determined using an automated spectrophotometric analysis method. TDH levels in all patient groups and control subjects were compared with each other. Results: The lowest native thiol, total thiol levels and native thiol/total thiol ratio were found in the MS relapse patients in comparison to the MS control, MS remission groups and healthy controls. In contrast, disulphide levels, disulphide/native thiol and disulphide/total thiol ratios were highest in the MS relapse group compared to the other patient groups and healthy subjects. Conclusion: Our findings indicate that increased oxidative stress in RRMS patients is reflected with decreased native and total thiol and increased disulphide levels. Since the formation of disulphide bonds is reversible, the progression of RRMS involving abnormal TDH may be controlled, converting disulphides to thiols. So, we suggest determining the dynamic TDH status as a novel and special biomarker in the diagnosis and prognosis of the RRMS patients. What’s known • Multiple sclerosis (MS) is a neuroinflammatory disease and inflammation and oxidative stress play important roles in its pathology. • Like other inflammatory diseases, oxidative stress is associated with MS playing an important role in the pathogenesis of MS. What’s new • Our study provides original data on dynamic Thiol/disulphide homeostasis (TDH) status in the relapsing-remitting multiple sclerosis (RRMS) patients at three different periods of the disease and examines whether plasma TDH can be used as a special oxidative stress biomarker in the diagnosis and follow-up of the RRMS patients and their response to the therapy
How did the COVID-19 pandemic affect audience’s attitudes in webinars?
(2021) Tanıdır, Yılören; Gökalp, Fatih; Akdoğan, Nebil; Batur, Ali Furkan; Şekerci, Çağrı Akın; Eğriboyun, Sedat; Değer, Mutlu; Şahin, Bahadır; Akarken, İlker; Aydın, Cemil; Altan, Mesut; Oktay, Ozman; Uçar, Murat; Güdeloğlu, Ahmet; Ongun, Şakir; Akbal, Cem; Esen, Adil
Introduction: Following the COVID-19 pandemic, the face-to-face meetings are delayed to a future date, which is still not clear. However, seminars, meetings and conferences are necessary for updating our knowledge and skills. Web-based seminars (webinars) are the solutions to this issue. This study aimed to show the participant behaviour when webinars present at the COVID-19 pandemic era. Methods: From December 2017 to July 2020, 58 webinars were broadcasted via the Uropedia, electronic library of SUST. Data of all webinars were collected with the YouTube analytics and application of the Uropedia. Data of streaming webinars included participant behaviours such as content views, engagement time, total unique attendees, average engagement time and the number of audience to leads. Data were split into two groups; group-1 is webinars before COVID-19 (before March 2020) and group-2 is the webinars during COVID-19. Results: Total broadcast time and total page view number were found to be 112.6 hours (6761 minutes) and 15 919, respectively. The median participant age was 40.1 y. Median content view and median engagement time were found to be 261.0 and 12.2 minutes, respectively. Comparison of two groups revealed a significant increment in the content views (group-1; 134.0 range = 86.0-87.0 and group-2; 414.0 range = 296.0-602.0, P < .001) and the number of the unique attendees (group 1; 18.0 range = 10.0-26.0 and group-2; 57.0 range = 27.0-100.0, P < .001) following COVID-19. However, the median engagement time of the audience did not seem to change with the COVID-19 pandemic (group-1; 11.5 range = 10.0-13.3 minutes and group-2; 13.2 range = 9.4-18.1 minutes, P = .12). Conclusion: The webinars are effective ways to share information and have many advantages, including low cost, reaching a high number of audiences. Audience number and page visits seemed to increase following the COVID-19 pandemic. However, this era did not seem to affect the critical attitude of the audience, which is engagement time.
Evaluation of the effect of a novel ?3-adrenergic agonist on choroidal vascularity
(2021) Topçuoğlu, Murat; Aslan, Fatih
PURPOSE. To determine the effect of the new ?3-agonist (mirabegron), which is used for overactive bladder (OAB) treatment, on central retinal thickness (CRT) and choroidal vascularity. MATERIAL AND METHODS. The 26 eyes of 26 cases using 50 mg tablet mirabegron once per day for OAB were included in this prospective case control study. The CRT, choroidal thickness (ChT), and choroidal vascularity were measured at baseline, week 1 (W1), month 1 (M1), month 2 (M2), and month 3 (M3). Subfoveal ChT measurement included the total subfoveal choroidal thickness (SFCT), and the small and large choroidal vessel layer (SCVL and LCVL) thickness. The total choroidal area (TCA), lumen area (LA), stromal area (SA), stroma/lumen ratio, and choroidal vascularity index (CVI) were measured with the Image-J software. RESULTS. The largest SFCT increase compared to baseline was at M1 (26.8 ± 40.8 ?m, P = 0.001). The subfoveal SCVL thickness showed a significant decrease at M2 and M3 (?6.0 ± 8.9 ?m, P = 0.002; ?7.8 ± 13.4 ?m, P = 0.046, respectively). LCVL thickness showed a significant increase at W1, M1, and M2, with the largest at M1. CVI showed a significant increase at M1, M2, and M3 (P < 0.05 for all). The TCA, LA, and SA showed a significant increasing trend at all follow-up periods. LA/SA decreased at W1 because of stromal expansion but increased at M3 with more prominent vascular dilatation. CRT values showed no significant change. CONCLUSIONS. Mirabegron had a significant effect on choroidal thickness. Choroidal vascular response is in the form of narrowing in the choriocapillaris and enlargement in the Haller's layer.
How safe and effective is stentless laparoscopic ureterolithotomy in elderly patients?
(2021) Aydın, Cemil; Akkoç, Ali; Aydın, Zeynep Banu
Purpose: With the improvement of minimally invasive urology procedures, open surgical interventions are less common to treat ureteral calculus. Laparoscopic ureterolithotomy (LU) indications are large multiple and/or impacted ureteral calculus that may not be treated with shock-wave lithotripsy or ureterorenoscopy approaches. The aim of our study was to investigate the feasibility and safety of stentless LU in elderly patients. Methods: Between October 2011 and December 2019, 38 geriatric patients underwent stentless transperitoneal LU for upper/mid ureteral calculi. The transperitoneal route was applied in all patients by two surgeons. No double J stent inserted in any patient. The data of all patients reviewed retrospectively. Results: The average age was 64.60 ± 3.70 years. The mean calculi size was 19.42 ± 1.41 mm. Ten patients had unsuccessful shock wave lithotripsy or ureterorenoscopy history. The calculi-free rate was 100%. Clavien grade 1 complications were seen in 11 (28.9%) cases. No major perioperative and postoperative complications were encountered. The average length of hospital stay was 3.24 ± 1.53 days. Conclusion: The significant advances in medical technology and healthcare, lead a rising number of geriatric patients to take benefit of even complicated surgery. Although laparoscopy and its safety in the geriatric population pursues a challenge and the assessment of this procedure is hence obligatory, we think that stentless LU is safe, economical and less uncomfortable for elderly patients.
Mechanical properties of muscles and tendons in asymptomatic individuals with generalized joint hypermobility
(2021) Taş, Serkan; Dikici, Tahir Fatih; Aktaş, A.; Aracı, Ayça
Background. The purpose of the present study was to investigate changes in mechanical properties of muscles and tendons in asymptomatic individuals with generalized joint hypermobility (GJH). Methods. This cross-sectional study was conducted in 126 participants aged 19-40 years. The Beighton score was used to determine whether the participants had GJH. An experienced physiotherapist screened all participants using the Beighton score to inquire about the presence of GJH. At the end of the clinical evaluations, 36 asymptomatic participants with GJH (age, 24.6 ± 6.1 years) and 34 age-and sex-matched controls (age, 24.6 ± 6.8 years) were included in the present study. The oscillation frequency (indicator of tone), dynamic stiffness (indicator of stiffness), and logarithmic decrement (related to elasticity) of the medial and lateral gastrocnemius, biceps brachii, and brachioradialis muscles, and the Achilles and patellar tendons were measured with a portable myotonometer (MyotonPRO, Myoton AS, Tallinn, Estonia). Results. The oscillation frequency, dynamic stiffness, and logarithmic decrement of the biceps brachii, brachioradialis, and medial and lateral gastrocnemius muscles were similar in GJH and control groups (p > 0.05). In addition, there was no significant difference between groups in terms of the oscillation frequency, dynamic stiffness, and logarithmic decrement of the Achilles and patellar tendons (p > 0.05). Conclusions. The elasticity, stiffness, and/or tone of the biceps brachii, brachioradialis, and medial and lateral gastrocnemius muscles were similar in individuals with and without GJH. The results obtained suggest that the mechanical properties of muscles and tendons are not associated with GJH.
Serial measurement of soluble endoglin for risk assessment at the diagnosis of fetal growth restriction
(2021) Erol Deniz, Merve; Deniz, Alparslan; Mendilcioğlu, İnanç; Sanhal, Cem Yaşar; Özdem, Sebahat; Küçükçetin, İkbal Özen; Kandemir, Hülya
Aim: In this study, we aimed to investigate the soluble endoglin (sEng) levels in pregnant women with fetal growth restriction (FGR) and to examine the possible relation of the sEng levels with the time remaining to delivery and maternal and fetal complications. Methods: A total of 42 pregnant women diagnosed with FGR were retrospectively reviewed. Using the maternal blood samples it is at the collected 24-37 gestational weeks, the sEng levels were measured. Fetal biometry measurements, umbilical artery, uterine artery, middle cerebral artery Doppler indices were documented. Results: Of all patients, 17 (40%) were diagnosed with early-onset FGR, while 25 (60%) were diagnosed with late-onset FGR. Abnormal Doppler findings were present in 25 (60%) patients. Of 42 newborns, 18 (42%) were hospitalised in the neonatal unit. The mean sEng level calculated by taking the average of the first and second blood samples was 63.24 ± 49.83 ng/mL. There was no statistically significant difference in the mean sEng levels between those who gave birth within four, three, and two weeks after the diagnosis of FGR and those who did not. There was a positive significant correlation between the mean sEng levels and systolic blood pressure (r = 0.319, P =.04). Conclusions: We did not find a statistically significant relationship between the sEng level and the time remaining to the time of delivery in pregnant women with FGR. We found no statistically significant difference in sEng level between the groups in pregnant women with fetuses with FGR with or without maternal and fetal complications.
A rare non-obstetric pathology in pregnancy: Obstructive sigmoid colon cancer
(2020) Çalış, Hasan; Çetin, Sıdkı
Sir, Colorectal cancer is a rare condition in pregnancy with reported incidence of 8 per million.1 Constipation, abdominal pain, vomiting, intermittent rectal bleeding and anemia, are frequently seen in pregnancy. Furthermore, these are also common in colorectal cancers.2 Because of these, the diagnosis of colorectal cancer in pregnancy may be delayed.3
Sapienic Acid Metabolism Influences Membrane Plasticity and Protein Signaling in Breast Cancer Cell Lines
(2022) Küçüksayan, Ertan; Sansone, Anna; Chatgilialoglu, Chryssostomos; Özben, Tomris; Tekeli, Demet; Talibova, Günel; Ferreri, Carla
Abstract: The importance of sapienic acid (6c-16:1), a monounsaturated fatty acid of the n-10 family formed from palmitic acid by delta-6 desaturase, and of its metabolism to 8c-18:1 and sebaleic acid (5c,8c-18:2) has been recently assessed in cancer. Data are lacking on the association between signaling cascades and exposure to sapienic acid comparing cell lines of the same cancer type. We used 50 µM sapienic acid supplementation, a non-toxic concentration, to cultivate MCF-7 and 2 triplenegative breast cancer cells (TNBC), MDA-MB-231 and BT-20. We followed up for three hours regarding membrane fatty acid remodeling by fatty acid-based membrane lipidome analysis and expression/phosphorylation of EGFR (epithelial growth factor receptor), mTOR (mammalian target of rapamycin) and AKT (protein kinase B) by Western blotting as an oncogenic signaling cascade. Results evidenced consistent differences among the three cell lines in the metabolism of n-10 fatty acids and signaling. Here, a new scenario is proposed for the role of sapienic acid: one based on changes in membrane composition and properties, and the other based on changes in expression/activation of growth factors and signaling cascades. This knowledge can indicate additional players and synergies in breast cancer cell metabolism, inspiring translational applications of tailored membrane lipid strategies to assist pharmacological interventions.
The Prevalence of Accessory Ossicles, Sesamoid Bones, and Biphalangism of the Foot and Ankle: A Radiographic Study Open Access
(2022) Candan, Büşra; Torun, Ebru; Dikici, Rumeysa
Abstract Background: Accessory ossicles, sesamoid bones, and biphalangism of toes are the most common developmental variations of the foot. These bones may be associated with painful syndromes; however, their clinical importance is not well understood because the reported prevalence varies widely. Therefore, we aimed to investigate these variants in Turkish subjects. Methods: A total of 1651 foot radiographs were retrospectively assessed. Radiographs of feet were examined regarding the prevalence, sex, and bilaterality of accessory ossicles, sesamoid bones, and biphalangism in Turkish subjects. Results: Accessory ossicles (26.1%) and sesamoid bones (8%) were detected. The most common accessory ossicles were os trigonum (9.8%), accessory navicular bone (7.9%), and os peroneum (5.8%). Also, we detected os supratalare (0.48%), os calcanei secundarium (0.42%) os subfibulare (0.42%), os supranaviculare (0.36%), os vesalianum (0.30%), os subtibiale (0.24%), os intermetatarseum (0.12%), and os subcalcis (0.12%). We observed bipartite hallux sesamoid in 1.8% and interphalangeal sesamoid bone of the hallux in 0.7% of radiographs. Incidences of metatarsophalangeal sesamoid bones were found as 0.6%, 0.06%, 0.6%, and 5.8% in the second, third, fourth, and fifth digit, respectively. We observed biphalangeal toe in 0.5%, 1.7%, 3.5%, and 37.6% in the second, third, fourth, and fifth toe, respectively. Conclusion: This study is the first detailed report on the incidence of the most common variants of the foot and ankle in a wide-ranging patients’ series in Turkish subjects. Our study’s findings will contribute to reducing misdiagnosis. Clinical Relevance: The results of this study may provide anatomical data that could help clinicians in the diagnosis and management of disorders that present with pain and discomfort in the feet. Knowledge of these variants is important to prevent misinterpreting them as fractures.
Idiopathic granulomatous mastitis and steroid use during the pandemic of COVID-19
(2022) Çalış, Hasan; Karabulut, Zülfikar; Güler, Yılmaz; Şengül, Serkan
Abstract. BACKGROUND: Steroid therapy is an immunosuppressive treatment and may have possible side effects in a pandemic period. However, the number of studies on the use corticosteroids for the treatment of idiopathic Granulomatous Mastitis (IGM) especially during the pandemic is almost negligible. METHODS: The data of patients with the diagnosis of IGM between January–December 2020 in the General Surgery Clinic were retrospectively analyzed. The patients were explained in detail that steroid therapy is an immunosuppressive treatment and it may have possible side effects. Prednisolone 0.5–1 mg/kg/day was given as steroid therapy. The treatment was planned for 4–6 months according to the severity of the symptoms and was completed by reducing it to a total dose of 10 mg/month. RESULTS: Eleven patients were included in the study. Five patients had completed steroid treatment and continued their followup. In our study, a total of six patients were receiving steroid therapy. CONCLUSIONS: There is no consensus yet on the use of the steroid in the COVID-19 pandemic. Low doses Corticosteroids (<1 mg/kg/day) don’t have an effect on increase mortality in patients with severe COVID-19. We can think that low-dose corticosteroids used by many centers in IGM treatment do not have a negative effect on mortality.

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