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Öğe Microleakage beneath orthodontic brackets in high field magnetic resonance imaging (MRI) AT 1.5 & 3 Tesla(2022) Bolat Gümüş, Esra; Şatır, Samed; Kuştarcı, AlperObjectives: The aim of the present study was to evaluate the effects of 1.5T and 3T MRI on the adhesion between the orthodontic brackets and the teeth by evaluating the microleakage between the enamel, adhesive and brackets interfaces. Methods: 58 extracted human premolars which were received a standard bracket bonding procedure were randomly divided into three groups; control group (n = 20; no MRI), 1.5T MRI group (n = 19; 20min MRI exposure of 1.5T) and 3T MRI group (n = 19; 20min MRI exposure of 3T). The teeth were kept in distiled water for 2 weeks, and thereafter subjected to 500 thermal cycles. Then, specimens were sealed with nail varnish, stained with 0.5% basic fuchsin for 24h, sectioned and photographed under a stereomicroscope. Microleakage was scored with regard to the adhesive–enamel and bracket–adhesive interfaces at the occlusal and gingival levels. Statistical analysis was accomplished by Kruskal–Wallis and Bonferroni–Dunn tests. Results: All of the groups exhibited statistically similar microleakage scores in the adhesive– enamel interface along occlusal margins (p>0.05, p = 0.331). The mean microleakage scores along gingival margins in the 3T MRI group was significantly higher compared to the control group both in the adhesive–enamel and bracket–adhesive interfaces (p<0.05, p = 0.019 and p = 0.020 respectively). The microleakage scores along the gingival margins were also significantly higher than the occlusal margins in the 3T MRI group (p<0.05, p = 0.029). Conclusions: 3T MRI may weaken the adhesion between the enamel and the stainless steel orthodontic brackeÖğe Cephalometric evaluation of intrusion of maxillary posterior teeth by miniscrews in the treatment of open bite(2022) Çime Akbaydoğan, Leyla; Akın, MehmetIntroduction: The objective of this research was to investigate the effectiveness of orthodontic miniscrews for skeletal anchorage during anterior open bite treatment using cephalometric radiographs. Methods: This study sample included 20 patients (mean age, 14.71; standard deviation, 1.77) with an anterior open bite. A total of 250 g of force was applied using elastic chains with anchorage from palatal miniscrew to an occlusal splint covering the posterior maxillary teeth. Cephalograms were obtained at the beginning of the treatment when the appliance was first applied and at the 8-month visit when treatment was completed. Paired t tests were used to identify statistically significant differences between initial and final measurements of skeletal and dental parameters. Results: A decrease of 2.72 6 1.90 in the SN-GoGn angle and 3.63 6 1.87 mm in the anterior height (N-Me) parameter in the cephalometric evaluations indicated a significant improvement of vertically increased facial dimensions, with the intrusion of the maxillary posterior teeth (P \0.05). Anterior rotation of the mandible was determined by a 1.76 6 1.09 increase in the SNB angle and a 1.86 6 0.90 decrease in the ANB angle (P \0.05). Reductions in the open bite amount by 5.8 6 0.90 mm, Mx6-SN by 4.00 6 1.01 mm, and Mx6-PP by 4.01 6 1.00 mm were indicative of significant intrusion in the maxillary posterior teeth (P \0.05). Conclusions: The present study confirmed that palatal miniscrew and maxillary occlusal splint caused intrusion of the maxillary posterior teeth, a decrease in the anterior open bite, and mandibular advancement, with anterior rotation after the maxillary posterior intrusion. We concluded that the treatment method in our study was appropriate for patients with Class I and mild Class II malocclusions and open bite anomalies. (Am J Orthod Dentofacial Orthop 2022;161:621-7)Öğe Investigation of the Antiangiogenic Properties of Zoledronic Acid by Using Chorioallantoic Membrane Model(2022) Gülcü, Anıl; Akkaya, ÖzgürObjective: Zoledronic acid (ZA) is a bisphosphonate-derived agent used in osteoporotic clinical pathologies to prevent the development of complications such as fractures and hypercalcemia by regulating bone metabolism. Studies have been conducted on the antiangiogenic efficacy of this agent, which also has other systemic side effects. In this study, the dose-dependent antiangiogenic activity of ZA was investigated on the chorioallantoic membrane model (CAM). Methods: Three doses (10-4, 10-5, and 10-6 M concentrations) of drug pellets were prepared with ZA and another pellet was prepared as the positive control group with vascular endothelial growth factor (VEGF) inhibitor agent bevacizumab (10-6 M concentration). Thereafter all pellets were placed on chorioallantoic membranes on the fourth day of egg incubation. All eggs were evaluated for capillary development four days after the drug application. Results: The highest antiangiogenic effect was detected in the positive control group. Moreover, incremental antiangiogenic effects were detected with average scores of .9, 1.1, 1.2 in 10-6, 10-5, and 10-4 M concentrations of ZA groups respectively. Conclusion: Our findings supported that ZA has dose-dependent antiangiogenic effects. This result suggests that different dosing may be required in cases where angiogenesis is therapeutic.Öğe Accuracy of emergency physicians' interpretation of computed tomography for urgent-emergent diagnoses in nontraumatic cases(2022) Karakoyun, Ömer Faruk; Kozacı, Nalan; Avcı, Mustafa; Uzunay, HüseyinOBJECTIVE: The aim of this study is to evaluate the accuracy levels of the emergency physicians (EPs) managing the patient in the interpretation of the urgent?emergent pathological findings in thoracic and abdominal computed tomography (CT) scans. METHODS: The EPs interpreted the CT scans of patients who visited the emergency department because of nontraumatic causes. Then, a radiology instructor made final assessments of these CT scans. Based on the interpretation of the radiology instructor, the false?positive rate, false?negative rate, sensitivity, specificity, positive predictive value, negative predictive value, and kappa coefficient (?) of the EPs’ interpretations of the CT scans were calculated. RESULTS: A total of 268 thoracics and 185 abdominal CT scans were assessed in our study. The overall sensitivity and specificity of the EPs’ interpretation of the thoracic CT scans were 90% and 89%, respectively, whereas the abdominal CT interpretation was 88% and 86%, respectively. There was excellent concordance between the EPs and the radiology instructor with regard to the diagnoses of pneumothorax, pulmonary embolism, pleural effusion, parenchymal pathology, and masses (?: 0.90, ?: 0.87, ?: 0.71, ?: 0.79, and ?: 0.91, respectively) and to the diagnoses of intraabdominal free fluid, intraabdominal free gas, aortic pathology, splenic pathology, gallbladder pathology, mesenteric artery embolism, appendicitis, gynecological pathology, and renal pathology (?: 1, ?: 0.92, ?: 0.96, ?: 0.88, ?: 0.80, ?: 0.79, ?: 0.89, ?: 0.88, and ?: 0.82, respectively). CONCLUSION: The EPs are successful in the interpretation of the urgent?emergent pathological findings in thoracic and abdominal CT scans.Öğe Utility of immature granulocyte in severity of helicobacter pylori infection(2022) Şengül, Serkan; Kubat, Mehmet; Güler, Yılmaz; Çalış, Hasan; Karabulut, ZülfikarIntroduction: Helicobacter pylori infection is a chronic bacterial infection associated with some extragastric diseases as well as gastric involvements that occur most commonly worldwide. In our study, we aimed to investigate the usability of immature granulocytes as a basic indicator that can reflect the severity of helicobacter pylori inflammation, to the best of our knowledge, for the first time. Materials and methods: Patients who underwent upper gastrointestinal endoscopy between April 2019 and April 2020 and were diagnosed with antral gastritis were included in this study. The relationship between helicobacter infection and its severity detected in gastric biopsies of patients and immature granulocyte count (IGC), immature granulocyte percentage (IG%), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volume (MPV) were investigated. Results: Of the 868 patients, 210 were HP negative, 658 were HP positive (218 mild HP positive, 293 moderate HP positive, and 147 severe HP positive). There were statistically significant differences between the HP negative and HP positive groups in terms of IGC, IG%, NLR, and PLR. However, IG% and IGC were not clinically useful because the median IG% (0.3 vs 0.3) and IGC (0.02 vs 0.02) were the same in the HP negative and total HP positive groups. Conclusion: In our study, IGC and IG% were not found useful to detect H. pylori intensity and severity of inflammation.Öğe Evaluation of Temperament and Character Traits and Their Subscale Dimensions Associated with Major Depressive Disorder(2022) Uygur, Abdullah Burak; Özdemir Öktem, Ece; Çelik, SelimeObjectives: The relationship between major depressive disorder (MDD) and, especially harm avoidance, self-directedness, and cooperativeness has been determined based on Cloninger's psychobiological personality model; there are not enough studies in the literature on the role of the subdimensions. Therefore, the aim of this study was to compare the patients with MDD and healthy controls in terms of temperament and character traits and especially subdimensions and thus to determine the role and predictive value of temperament and character subdimensions in major depression patients. Methods: The sample of this cross-sectional study consisted of 105 participants, 65 of whom were MDD patients, and 40 healthy controls, who voluntarily agreed to participate in the study. Sociodemographic data form, temperament and character inventory, and Hamilton depression rating scale were administered to the participants. Results: Compared with healthy controls, patients with MDD had lower self-directedness (p<0.001), cooperativeness (p=0.017), persistence (p<0.001), self-transcendence (p=0.001), and higher harm avoidance (p<0.001) scores. While there was no significant difference in novelty seeking (p=0.774); it was determined that MDD patients got higher scores in "Impulsiveness" (p=0.013) and lower scores in "Exploratory excitability" (p=0.001) subscales. Reward dependence has been identified as the only personality trait that there was no significant difference between major depression patients and healthy controls (p=0.511). As a result of the logistic regression analysis performed to determine the predictors of temperament and character subdimensions in major depression patients, only three temperament and character traits "Fatigability, Purposefulness, and Spiritual Acceptance" were determined as significant predictors (p<0.001). Fatigability was determined to be a serious risk factor, increasing the probability of MDD 3.6 times (p<0.001); purposefulness and spiritual acceptance were found to be protective personality traits that together reduced the probability of MDD by 0.8 times (p<0.001). Conclusion: This study shows that the risk of developing MDD is increased in individuals with low self-directedness, cooperativeness, persistence, and self-transcendence profiles, and whereas with prominent Harm avoidance personality traits. Therapeutic interventions, especially considering the temperament and character traits of "Fatigability, Purposefulness, and Spiritual Acceptance" determined in our study, may contribute positively to MDD treatment.Öğe The Impact of COVID-19 Pandemic on Urological Emergencies, 8 Months Results of a Multicenter Retrospective Study From Turkey(2022) Alkış, Okan; Başer, Aykut; Çağlayan, Mustafa Serdar; Teke, Kerem; Avcı, İbrahim Erkut; Yaşar, Adem; Keskin, Ercüment; Yüksekkaya, Mustafa; Celen, Sinan; Özlülerden, Yusuf; Ölçücü, Mahmut Taha; Uçar, Murat; Güzel, Ahmet; Asutay, Mehmet Kazım; Bahçeci, Tuncer; Öncel, Halil FeratObjectives: We aimed to reveal the change of urological emergencies during the COVID-19 pandemic compared to the same period of the previous year. Methods: The number of admissions to the emergency department (ED), admissions to the urology outpatient clinic, emergency urological consultations, and urological and emergency urological surgeries during the periods April-November-2019 and April-November-2020 were recorded. The data of the COVID-19 period were compared with the previous year. Results: While the number of admissions to the urological outpatient clinic was 160,447 during the COVID period, it was 351,809 during the non-COVID period. The number of admissions to the ED decreased from 3.2 million to 2.4. The number of admissions to the urology outpatient clinic significantly decreased by 54% during the pandemic (p=0.001). Percutaneous cystostomy performed due to acute urinary obstruction decreased by 27.96%, double J stent, nephrostomy decreased by 16.61%, and ureterorenoscopy decreased by 12.26%. Urogenital trauma also decreased. On the contrary, surgical procedures performed due to penile fracture, gross hematuria, Fournier gangrene, and testicular torsion increased. Conclusion: During the COVID-19 pandemic, a significant decrease was observed in non-COVID patients' admissions to the emergency and urology department, and in urologic surgeries.Öğe Clinical and radiological characteristics of pulmonary actinomycosis mimicking lung malignancy(2022) Baykal, Hüsnü; Ülger, A. Füsun; Çelik, Deniz; Benli Tanrıkulu, Fatma; Tatçı, EbruINTRODUCTION: Pulmonary actinomycosis, clinically and radiologically, mimics abscess, tuberculosis, and lung malignancy, resulting in misdiagnosis or delay in diagnosis. In this study, we analyzed the clinicoradiological features of pulmonary actinomycosis, the presence of any differences between clinical prediagnosis and radiological diagnosis, and whether imaging modalities help distinguish pulmonary actinomycosis from lung cancer. METHODS: A total of 22 patients who had a histopathological diagnosis of actinomycosis in a tertiary health center participated in this study. Of these, 14 had positron-emission tomography/computed tomography. RESULTS: In all, 81.8% of the patients were males. The diagnostic procedures employed for the diagnosis of actinomycosis were surgery in 54.5% of patients, fiberoptic bronchoscopy in 36.4% of patients, and rigid bronchoscopy in 9.1% of patients. Radiological and clinical prediagnosis showed malignancy in 31.8 and 40.9% of patients, respectively. The mean of the maximum standardized uptake value was 6.33±3.6 on positron-emission tomography/computed tomography. Kappa compliance analysis revealed that clinical and radiological diagnoses were significantly compatible with each other and that radiological pre-diagnoses were not superior to clinical diagnoses (?=0.701 and p<0.001). CONCLUSION: Pulmonary actinomycosis shows high metabolic uptake in positron-emission tomography/computed tomography, and this may mislead clinicians for a diagnosis of malignancy. Our results suggest that positron-emission tomography/computed tomography does not help distinguish pulmonary actinomycosis from lung malignancy and does not provide a clear diagnostic benefit to the clinician, so pathological diagnosis is necessary.Öğe Association of Frontal and Maxillary Bone Fractures and Concomitant Craniocerebral Injuries in Patients Presenting with Head Trauma(2022) Orhan Kubat, Gözde; Şahin, C.; Özen, Ö.Background: Maxillofacial fractures and craniocerebral injuries are common in patients with head trauma. These are injuries with high mortality and morbidity. Therefore, patients with head trauma should be evaluated early with a multidisciplinary approach. Aim: The association between frontal and maxillary bone fractures and concurrent craniocerebral injuries were investigated in patients presenting with head trauma in this study. The data of the patients were analyzed retrospectively. Methods and material: Age and gender distributions were evaluated in frontal and maxillary fractures. Concomitant craniocerebral injuries were investigated. Craniocerebral injuries were grouped as pneumocephalus, extra-axial, intra-axial injuries and brain edema. Craniocerebral injuries in frontal and maxillary fractures were compared statistically. Results: Frontal bone and maxillary bone fractures were detected in 24% and 95% of the patients. Coexistence of pneumocephalus and intra-axial injuries in frontal bone fracture was statistically significant. The association of frontal posterior wall fractures with pneumocephalus and parenchymal contusion was found to be statistically significant. In addition, the association of craniocerebral injuries were evaluated and statistically significant ones were determined. Conclusion: The presence of maxillofacial fractures in patients presenting with head trauma increases mortality and morbidity. Craniocerebral injuries can be life-threatening and delay the treatment of facial fractures. Upper facial bone fractures are significantly more common in craniocerebral injuries.Öğe Trace Elements (Zn and Cu) and Oxidative Stress in Pediatric Patients with Persistent Allergic Rhinitis(2022) Günizi, Hüseyin; Savaş, Hasan Basri; Genç, SibelObjective: To investigate the relationship between complaints and serum trace elements and oxidative stress levels in pediatric patients with allergic rhinitis (AR). Study design: Descriptive study. Place and duration of study: Department of Otolaryngorhinology, Medicine Faculty, Alanya Alaaddin Keykubat University, between May and September 2020. Methodology: Thirty-five patients diagnosed with AR in the pediatric age group and 35 healthy control groups were examined. The patients were evaluated according to the ARIA (Allergic rhinitis and its ımpact on asthma) guidelines. Blood samples were taken during the attack to measure serum Zn and Cu levels and oxidative stress levels from patients diagnosed with AR. Measurements of serum Zinc and Copper levels, and recently developed new generation oxidant-antioxidant balance markers were performed spectrophotometrically using a commercial kit.] Results: The mean ages of the study patients and healthy controls were 10.9 ± 4.7 and 10.5 ± 4.9 years, respectively. Female/Male ratio was 20 (57.1%)/15 (42.9%) in both groups. Zn level was lower in the patient group (p <0.05). Total thiol and native thiol values were higher in the control group (p <0.05). Statistically significant high disulfide values were found in allergic patients (p <0.05). Conclusion: Oxidative stress plays a role in the pathophysiology of allergic rhinitis, and thiol-disulfide hemostasis may be an indicator in allergic rhinitis. Key Words: Oxidative stress, Allergic rhinitis, Thiol, Disulfide, Cu, Zn.Öğe Moderating Effects of Teacher-Child Relationship on the Association Between Unsociability and Play Behaviors(2022) Metin Aslan, Özge; Boz, MenekşeThe present study aimed to examine the moderating role of the quality of the relationship between children and their teachers (i.e., closeness and conflict), in children's unsociability and play behaviors (i.e., reticent behavior, social play). Participants were 211 three- to six-year-old children (M = 64.08 months, SD = 10.92, 94 girls, 117 boys). Mothers reported their unsociability; teachers reported teacher-child relationships and children's play behaviors. Results showed that close teacher-child relationships moderated the association between unsociability and social play in children (buffering effect). Teacher-child conflict exacerbated the relations between unsociability and reticent behavior. Findings show that teacher-child closeness is effective in revealing social play behaviors of unsociable children. Teachers can improve their relationship with unsociable children to provide nurturing social play behavior.Öğe Passive mechanical properties of extrinsic foot muscles and Achilles tendon in adults with and without pes planus(2022) Taş, Serkan; Aktaş, Arda; Tüfek, Muhammed TahaThe purpose of the present study was to investigate the changes in stiffness, tone, and elasticity of extrinsic foot muscles and Achilles tendon in adults with pes planus at rest and during standing. The study was conducted with 59 participants, 29 with pes planus and 30 with normal foot posture. The oscillation frequency (indicator of tone), dynamic stiffness (indicator of stiffness), and logarithmic decrement (related to elasticity) of the Achilles tendon, peroneus longus, tibialis anterior, and medial and lateral gastrocnemius muscles were measured with a myotonometer (MyotonPRO, Myoton AS, Estonia). The passive mechanical properties of the selected muscles and tendon were measured at rest and during standing. The oscillation frequency, dynamic stiffness, and logarithmic decrement of the peroneus longus, tibialis anterior, and medial and lateral gastrocnemius muscles were similar in individuals with and without pes planus (p < 0.05). Individuals with pes planus had higher dynamic stiffness of the Achilles tendon at rest (p = 0.042; d = 0.431), whereas they had lower dynamic stiffness of the Achilles tendon with a moderate effect size during standing compared to controls (p = 0.028; d = 0.640). The logarithmic decrement of the Achilles tendon in individuals with pes planus was significantly lower with a large effect size during standing (p = 0.025; d = 0.945). The results obtained suggest that pes planus is not related to the passive mechanical properties of the foot extrinsic muscles. A decrease in stiffness and an increase in elasticity during standing, and an increase in stiffness at rest in the Achilles tendon were found in individuals with pes planus.Öğe COVID-19 disease diagnosis from paper-based ECG trace image data using a novel convolutional neural network model(2022) Irmak, EmrahClinical reports show that COVID-19 disease has impacts on the cardiovascular system in addition to the respiratory system. Available COVID-19 diagnostic methods have been shown to have limitations. In addition to current diagnostic methods such as low-sensitivity standard RT-PCR tests and expensive medical imaging devices, the development of alternative methods for the diagnosis of COVID-19 disease would be benefcial for control of the COVID-19 pandemic. Further, it is important to quickly and accurately detect abnormalities caused by COVID-19 on the cardiovascular system via ECG. In this study, the diagnosis of COVID-19 disease is proposed using a novel deep Convolutional Neural Network model by using only ECG trace images created from ECG signals of COVID-19 infected patients based on the abnormalities caused by the COVID-19 virus on the cardiovascular system. An overall classifcation accuracy of 98.57%, 93.20%, 96.74% and AUC value of 0.9966, 0.9771, 0.9905 is achieved for COVID-19 vs. Normal, COVID-19 vs. Abnormal Heartbeats, COVID-19 vs. Myocardial Infarction binary classifcation tasks, respectively. In addition, an overall classifcation accuracy of 86.55% and 83.05% is achieved for COVID-19 vs. Abnormal Heartbeats vs. Myocardial Infarction and Normal vs. COVID-19 vs. Abnormal Heartbeats vs. Myocardial Infarction multi-classifcation tasks. This study is believed to have great potential to speed up the diagnosis and treatment of COVID-19 patients, saving clinicians time and facilitating the control of the pandemic.Öğe How did the COVID-19 pandemic affect older adults? Investigation in terms of disability, state-trait anxiety and life satisfaction: Samsun, Turkey example(2022) Özpınar, Saliha; Bayçelebi, Saadettin; Demir, Yaşar; Yazıcıoğlu, BahadırBackground: The COVID-19 pandemic has adversely affected the physical and mental health of individuals. The elderly are a special group that is affected by this condition. The aim of this study was to investigate the effect of the COVID-19 pandemic on older adults in terms of disability, state–trait anxiety and life satisfaction. Methods: The population of this cross-sectional study consisted of individuals aged 65 and over who presented to a family health centre in Samsun a province of Turkey on the Black Sea coast (N = 3950). The study data were collected with the following five forms: Personal Information Form, Quality of Life Questionnaire, State–Trait Anxiety Inventory, Brief Disability Questionnaire and Life Satisfaction Scale. In the analysis of the study data, descriptive statistics, Student’s t-test, paired t-test, analysis of variance, Pearson correlation and multiple regression analysis were used. Results: The mean age of the participants was 70.88 4.818 years. There was a significant difference between the participants’ pre- and postpandemic health status and quality of life levels. In the study, a significant relationship was determined between the scores obtained from the State– Trait Anxiety Inventory, and the Brief Disability Questionnaire and between the scores obtained from the State–Trait Anxiety Inventory and the variables such as income and marital status (P < 0.05). Conclusion: A significant result of the study is that the older adults’ perceptions of health status and quality of life were adversely affected by the pandemic. Another significant result is that disability increased the level of anxiety. The other significant result of the study is that socioeconomic status was an important determinant of anxiety.Öğe The relationship between oral cancer and cadmium: a review(2022) Şatır, SamedCadmium (Cd) has been classifed as a type I carcinogen. Since it is ingested orally through food and tobacco use, Cd is likely to be closely related to oral cancers. The relationship between cadmium and oral cancer was investigated using papers on Pubmed and Web of Science. Thus a total of 11 studies from these databases were included in the review. Cd concentrations were signifcantly higher in both the blood and hair of oral cancer patients than in controls. Additionally, it has been reported that Cd increases the activity of reactive oxygen species. Tobacco plants contain varying levels of Cd. The presence of high Cd concentrations in patients who use tobacco products and develop oral cancer is strong evidence that Cd is directly related to oral cancer. While planning a study to determine the Cd concentrations in biological samples, it is advisable to examine the methodologies of previous studies and to avoid technical defciencies. New cell line studies are required to explain the relationship between Cd and autophagy-apoptosis.Öğe Choroidal thickness changes in healthcare professionals wearing surgical masks or FFP2 masks: Pilot study(2022) Kurt, Ali; Altındal, Emin UtkuPurpose: To evaluate the choroidal thickness (CT) with enhanced depth-imaging optical coherence tomography (EDI-OCT) in healthcare professionals using surgical masks or FFP2 (N95) masks. Methods: We included the 120 eyes of 120 healthy volunteers who were using a surgical mask (Group 1) or FFP2 mask (Group 2) in the study. Spectral domain (SD) OCT was used to measure CT. EDI-OCT was used to measure subfoveal and perifoveal CT. Points 1500 ?m nasal (CN1500) and temporal (CT1500) to the foveal center were used to measure perifoveal CT. Oxygen saturation and heart rate were measured with a pulse oximeter. All measurements were performed at 8:30, before wearing the mask, and at 12:30, when the mask was removed for the lunch break. Results: Of a total of 120 subjects, Group 1 consisted of 60 subjects (mean age 38.50±8.60 (range 24–44) years) and Group 2 also consisted of 60 subjects (mean age 36.60±6.53 (range 26–45) years). Although not statistically significant, CT was seen to have increased at 3 measurement points in Group 1 after using the mask for 4 h: subfoveal CT (CSF) (p = 0.545), CT1500 (p = 0.080), and CN1500 (p = 0.251)). In Group 2, the increase in CSF (p = 0.001) was statistically significant while the increases in CN1500 and CT1500 were not (p = 0.162 and p = 0.058, respectively) after using the mask for 4 h. Conclusion: We found CT to increase after 4 h of mask use, and this increase was more marked in Group 2. The increase in subfoveal CT in particular was statistically significant in Group 2.Öğe Evaluation of antibody response after COVID?19 vaccination of healthcare workers(2022) Uysal, Elif B.; Gümüş, Sibel; Bektöre, Bayhan; Bozkurt, Hale; Gözalan, AyşegülThe common goal of all vaccines developed against COVID-19, although they have been designed with different methods, is to develop an effective immunity and antibody response against SARS-CoV-2. However, the postvaccination immune response and antibody levels differ between individuals. This study examined the relationship between postvaccine seropositivity rates, age, gender, smoking, and body mass index (BMI), and antibody titers. A total of 314 healthcare workers (HCW) who were not previously infected with COVID-19 and who had received two doses of CoronaVac inactivated vaccine participated in the study. Seropositivity against the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein was measured from the participants 4 weeks after the second dose of vaccine using the electrochemiluminescence (ECLIA) method. In addition, the antibody developed against the nucleocapsid protein (NCP) was evaluated and compared using Elecsys Anti-SARS-CoV-2 kit. One hundred and eighty-one of the participants were female (57.6%) with a median age of 39 (interquartile range [IQR], 10) and 133 (42.4%) were male with a median age of 41 (IQR, 11). 99.6% of the volunteers developed seropositivity 4 weeks after the second dose of vaccine. It was also observed that the rate of RBD protein antibody titer was >250 U/ml in smokers, which is quite low compared to nonsmokers (p = 0.032), and that high RBD antibody titers were proportionally lower in obese participants, according to BMI values, compared to those with normal BMI (49.5% and 9.9%). It was observed that seropositivity developed in almost all participants after the CoronaVac vaccine. However, it was determined that the antibody titer measured varied depending on factors such as smoking, BMI, and duration.Öğe Effect of pseudoexfoliation syndrome on lamina cribrosa morphology after uneventful phacoemulsification(2022) Aslan, Fatih; Şahinoğlu Keşkek, Nedime; Altındal, Emin UtkuAim: To evaluate the behavior of the lamina cribrosa (LC) following successful phacoemulsification (PE) surgery in non-glaucomatous PXS cases with cataract. Methods: A total of 25 bilateral PXS and 56 non-PXS cataract patients were included in this prospective, interventional, and controlled study. The lamina cribrosa thickness (LCt) and anterior laminar depth (ALD) were measured horizontally and vertically from two sections using EDI-OCT. The measurements were taken preoperatively, and the LCt and ALD measurements were repeated at week one (W1), month one (M1), month two (M2), and month three (M3) postoperatively. Results: The baseline horizontal and vertical LCt values were found to be significantly thinner in the PXS group (p = 0.001, p = 0.006 respectively). The horizontal section ALD values were 463.32 ± 98.82 µm and 383.88 ± 85.8 µm (p < 0.001) for the PXS and non-PXS groups, respectively, and this significance continued during follow-up. The vertical ALD values were 469.64 ± 117.83 µm and 390.3 ± 98.1 µm (p = 0.002) in the PXS and non-PXS groups, respectively. There was no significant change in the PXS group for the depth following PE, but a statistically significant depth increase response was observed in the non-PXS group during follow-up. Conclusion: It is possible to conclude that the bending capacity of the lamina cribrosa may be lower than seen in the normal population, but we do not know how this lack of flexibility will affect the eye.Öğe Effect of Vertical and Lateral Offset Restoration on Clinical Outcomes in Intracapsular and Extracapsular Hip Fractures Undergoing Hemiarthroplasty(2022) Dinçer, Recep; Gülcü, Anıl; Tolga, Atay; Başal, Özgür; Aslan, Ahmet; Baykal, Yakup B.Objective We aimed to investigate whether there is a change in the postoperative lateral and vertical femoral offset (FO) in patients who underwent bipolar straight stem hemiarthroplasty (SSHA) and calcar stem hemiarthroplasty (CRHA) and whether this change makes a difference in the comparison of both groups. Material and methods This study included 109 patients who met these criteria. Patients are divided into two groups according to treatment methods. There were 58 patients (group 1) who underwent SSHA due to intracapsular (AO type 31-B neck and 31-C head fracture) femur fracture, and there were 51 patients (group 2) who underwent CRHA due to extracapsular (AO type 31-A intertrochanteric) femur fracture. We analyzed femoral vertical and lateral femoral offset, Wiberg angle, and head-neck angle difference in both groups. Results The median age was significantly higher in the CRHA group (p=0.042). The Harris hip score (HHS) was significantly higher in the SSHA group (p=0.023). The femoral offset difference was 5 mm in the SSHA group, while it was significantly lower (-6 mm) in the CRHA group (p<0.001). The Wiberg angle difference did not differ significantly between patient groups (p=0.214). The limb length difference was found to be similar in both surgical groups (p=0.483). Conclusions The study results show that there was no negative correlation between clinical and radiological outcomes in the SSHA group, whereas there was a negative correlation between clinical and radiological outcomes in the CRHA group. It is very difficult to control vertical and lateral offset reconstruction, especially in extracapsular hip fractures reconstructed by hemiarthroplasty. Deficiencies in lateral and vertical stabilization restoration may be associated with poor clinical outcomes in CRHA patients. Orthopedic surgeries should be performed carefully when restoring leg length and femoral offset, especially calcar replacement hemiarthroplasties.Öğe Crystallized phenol treatment vs excision and primary closure in pilonidal sinus disease: A randomized clinical trial in adolescent patients(2022) Şengül, Serkan; Güler, Yılmaz; Çalış, Hasan; Kubat, Mehmet; Karabulut, ZülfikarIntroduction: Pilonidal sinus is a chronic inflammatory disease seen in the intergluteal sulcus. A wide variety of treatment modalities have been described for the management of this disease, however optimal therapy remains controversial. The study aims to compare phenol treatment, a minimally invasive method used in the treatment of pilonidal sinus disease, with the commonly practiced surgical methods of excision and primary closure in the adolescent age group. Patients and methods: Adolescent patients who presented with pilonidal sinus disease between January 2018 and December 2018 were randomized into 2 groups as phenol treatment and surgical treatment (after obtaining consent for the study). Early complications and recurrence rates after 24 months of follow-up were the two main endpoints of the study. Results: A total of 100 patients (phenol group n = 50, surgery group n = 50) were included in the study. Both groups were similar in terms of age, gender, and BMI. The mean duration of the procedure was 12.4 ± 2.84 min in the phenol group and 42.3 ± 7.22 min in the surgery group (p = 0.00). There was no difference in postoperative complications between the groups (p = 0.22). After 24 months of follow-up, recurrence was found in 8% (n = 4) of the cases in the phenol group and 10% (n = 5) of the cases in the surgery group (p = 0.5). Conclusion: In our study, phenol treatment and excision/primary closure methods for pilonidal sinus disease have similar complication and recurrence rates. However, phenol treatment seems to be the method of choice in the adolescent age group as it has the advantage of being a minimally invasive method and it does not affect subsequent surgical treatments. Level of evidence: Level II treatment study.
