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Öğe The Impact of Parents' Digital Awareness on their Digital Attitude Behaviors(Taylor & Francis Inc, 2025) Teke, Busra; Ayar, DijleIn today's world, in which technology has become an inseparable part of daily life, the use of digital technology is increasingly common among children. It is important to investigate the topic of digital technology use, which can affect children's social, emotional, psychological, mental, and physical development in many ways, as well as the reasons that can influence the characteristics they should possess. This study was conducted to evaluate the effect of parents' digital awareness on their digital attitude behaviors. This study was descriptive, cross-sectional and correlational. The study was conducted with parents (n = 545) Descriptive Information Form, Digital Parenting Awareness Scale and Digital Parenting Attitude Scale were used as data collection tools in the study. It was determined that there was a strong and negatively significant relationship between the mean total scores of the parents' digital attitude behaviors and digital neglect (r = -0.529, p < .001), strong negative significant relationship (r = -0.643, p < .001) between the mean scores of parents' digital attitude behaviors and negative modeling sub-dimension (r = -0.643, p < .001). It was determined that there was a strong negative significant relationship between parents' digital attitude behaviors and the condition of being a negative role model, a moderate negative significant relationship with the condition of digital neglect, a moderate positive significant relationship with the condition of efficient use, and a moderate positive significant relationship with the condition of risk protection.Öğe Particle stabilised high internal phase emulsion scaffolds with interconnected porosity facilitate cell migration(Iop Publishing Ltd, 2025) Munive-Olarte, Areli; Durgut, Enes; Verbruggen, Stefaan W.; Claeyssens, Frederik; Reilly, Gwendolen C.A key challenge in bone tissue engineering (BTE) is designing structurally supportive scaffolds, mimicking the native bone matrix, yet also highly porous to allow nutrient diffusion, cell infiltration, and proliferation. This study investigated the effect of scaffold interconnectivity on human bone marrow stromal cell (BMSC) behaviour. Highly interconnected, porous scaffolds (polyHIPEs) were fabricated using the emulsion templating method from 2-ethylhexyl acrylate/isobornyl acrylate (IBOA) and stabilised with similar to 200 nm IBOA particles. Pore interconnectivity was tuned by varying the internal phase fraction from 75%-85% and characterised by the degree of openness, Euler number, frequency, and size of pore interconnects. The attachment, proliferation, infiltration, and osteogenic differentiation of the BMSC cell line (Y201) were evaluated on these scaffolds. Results showed that high pore interconnectivity facilitated diffusion and cell infiltration throughout the scaffolds. Furthermore, the most interconnected scaffolds enhanced osteogenic differentiation of Y201 cells, as evidenced by elevated alkaline phosphatase activity and increased calcium and collagen production compared to less interconnected scaffolds. These findings emphasise the importance of scaffold interconnectivity in BTE for efficient nutrient transport, facilitating cell migration and infiltration, and supporting the development of interconnected cell networks that positively influence osteogenic differentiation.Öğe The Effect of Psychological Distress and Intimate Partner Violence on Treatment Adherence in the Mothers of Children with Attention Deficit Hyperactivity Disorder(Routledge Journals, Taylor & Francis Ltd, 2025) Kocaman, Orhan; Tekin, Ugur; Yilmaz, Semra; Ok, Sena SaygiliThis study examines the effects of maternal psychological distress and the Intimate partner violence (IPV) to which mothers are exposed on treatment adherence. 55 mothers of children diagnosed with ADHD and 51 mothers of healthy children were included in the study. Psychological distress and IPV were greater in the mothers of children with ADHD than in those of healthy children. Greater IPV was determined in the low treatment adherence group among the mothers of children with ADHD than in the moderate-high adherence. Holistic approaches in ADHD in which the mother's mental health is included can increase adherence to treatment.Öğe The Effect of Nursing Students' Liking of Children and Attitudes Toward Clinical Practice on Their Comfort and Worry Levels in the Pediatric Clinic(Taylor & Francis Inc, 2024) Kudubes, Asli Akdeniz; Zengin, Hamide; Ayar, Dijle; Bektas, Ilknur; Bektas, MuratThis research was conducted as a descriptive and cross-sectional study to determine the effects of nursing students' liking of children and attitudes toward clinical practice on their comfort and worry levels in the pediatric clinic. The research was carried out with 270 nursing students who had already taken or were taking the child health and diseases nursing course. Data were collected using a Nursing Student Information Form, the Barnett Liking of Children Scale, the Nursing Students' Attitudes toward Clinical Practices Scale, and the Pediatric Nursing Student Clinical Comfort and Worry Assessment Tool. Mean values, percentage calculations, and linear regression analysis were used for the analysis of the research data. Participants' mean scores were 52.30 +/- 6.16 on the Barnett Liking of Children Scale, 103.72 +/- 19.35 on the Nursing Students' Attitudes toward Clinical Practices Scale, 15.61 +/- 3.74 on the comfort sub-dimension, and 11.63 +/- 4.32 on the worry sub-dimension of the Pediatric Nursing Student Clinical Comfort and Worry Assessment Tool. It was determined that the liking of children and attitudes toward clinical practice explained 43.6% of the clinical comfort level of pediatric nursing students in Model 1 and 45.2% of their clinical worry level in Model 2. It was determined that the liking of children and attitudes toward clinical practice significantly affected the comfort and worry levels of nursing students in the pediatric clinic.Öğe Molecular investigations on T cell subsets in patients affected by hypomorphic DCLRE1C mutation(Taylor & Francis Ltd, 2025) Karaselek, Mehmet Ali; Duran, Tugce; Kuccukturk, Serkan; Hazar, Esra; Dogar, Oznur; Kiykim, Ayca; Guner, SukruObjectiveIn this study, we explored the expression of transcription factors, cytokines, and co-stimulatory molecules within the helper T (Th) cell subsets (Th1, Th2, Th17, and Treg) of patients with hypomorphic DCLRE1C gene mutations. MethodsThe study comprised eight patients and five controls. Transcription factor and cytokine expressions of Th subsets and co-stimulatory molecules were investigated by qPCR and flow cytometric following T cell stimulation. The findings were compared between patients (non-HSCT) and with hematopoietic stem cell transplantation (HSCT). ResultsFlow cytometric analyses; while the Treg rate was significantly lower in non-HSCT than in controls (p = 0.010), the IFN-gamma rate was significantly higher in patients than in the control and HSCT groups (p = 0.016, p = 0.022, respectively). Co-stimulatory molecule expressions were significantly lower in non-HSCT than in control (p < 0.001), and there was a significant improvement after HSCT. Post-stimulation qPCR analysis, significant changes were detected in non-HSCT/control, non-HSCT/HSCT, and HSCT/control comparisons. ConclusionsOur study is the first study to molecularly investigate Th cell subsets in hypomorphic DCLRE1C patients. It was determined that abnormalities in Th cell subsets still persisted despite HSCT. There are still many conditions to be explained in these patients, and we believe that our study may shed light on future studies.Öğe Evaluation of primary markers of inflammation and the systemic inflammation index in specific learning disabilities(Taylor & Francis Ltd, 2024) Avsar, Pinar Aydogan; Kara, Tayfun; Kocaman, Orhan; Akkus, MerveAim: Specific learning disorder (SLD) is a term that refers to reading, writing and arithmetic difficulties. The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and systemic inflammation index (SII) are affordable and accessible inflammatory biomarkers. This research aims to evaluate the relationship between NLR, PLR, SII and SLD to determine whether inflammation contributes to pathogenesis. Methods: This study included 90 SLD-diagnosed patients and 90 age-, sex- and ethnicity-matched healthy controls. Blood cell counts and NLR, PLR and SII values were obtained from medical records and compared between the two groups. Results: The NLR, PLR and SII were significantly higher (p = 0.029, p = 0.033 and p = 0.018 respectively) and lymphocyte counts were significantly lower (p = 0.041) in the SLD group. WISC-R total scores decreased with age in the SLD group (-1.988 coefficient, Beta = -0.247 beta, p = 0.041). Multivariate logistic regression analysis revealed that the SII was the only parameter independently associated with the diagnosis of SLD (Beta = 0.003, p = 0.023). Conclusion: Inflammation might play a role in SLD etiopathogenesis. NLR, PLR and SII may be potential biomarkers for SLD in children. Further research may lead to early diagnosis and additional anti-inflammatory pharmacological therapies for SLDs.Öğe A preliminary study on patulin contamination in spirit drinks(Taylor & Francis Ltd, 2022) Golge, Ozgur; Yenisehirlioglu, Emirhan; Kabak, BulentA total of 120 spirit drinks and 40 apple juices were collected between 2018 and 2020 in three regions of Turkey and analysed by high-performance liquid chromatography coupled with a photodiode array detector (HPLC-PDA) for the incidence of patulin. The analytical method was successfully validated for both matrices. In 26.7% of apple juice samples, patulin was quantified at levels between 5.8 and 66.4 mu g L-1. Only one regulatory level exceedance was identified for apple juice. The mean dietary exposure of the adult population to patulin ranged from 0.083 to 0.091 ng kg(-1) bw day(-1). With the HPLC-PDA method, patulin was measured in quantifiable concentrations in 11 out of 25 cognac, 5 out of 40 liqueur, and 1 out of 10 whisky samples, up to a level of 42.6 mu g/l, whereas all vodka samples were free from patulin. In only one liqueur sample, the presence of patulin could be confirmed with LC-MS/MS, at a level of 8.9 mu g L-1.Öğe Efficacy and safety of omitting 5-fluorouracil bolus in combination chemotherapy regimens for gastrointestinal cancers: a systematic review and meta-analysis(Taylor & Francis Ltd, 2025) Ilhan, Yusuf; Balcik, Onur Yazdan; Sahin, Elif; Merc Cetinkaya, Aysegul; Almuradova, Elvina; Bardakci, Murat; Dinckal, CigdemIntroductionThis meta-analysis aimed to evaluate the impact of omitting the 5-FU bolus in chemotherapy regimens for gastrointestinal cancers on treatment efficacy and toxicity.MethodsWe searched major databases and congress proceedings until 25 October 2024 to identify studies comparing 5-FU bolus and non-5-FU bolus regimens in patients with gastrointestinal cancers. The studies included those reporting on progression-free survival (PFS), overall survival (OS), and adverse events in metastatic gastrointestinal cancer patients.ResultsThe analysis included 7 studies with 12,698 patients. No significant differences in PFS (HR: 0.94, 95% CI: 0.83-1.07) or OS (HR: 0.96, 95% CI: 0.89-1.03) were found between the 5-FU bolus and non-bolus groups. However, significantly higher rates of grade 3-4 neutropenia (OR: 0.46, 95% CI: 0.37-0.57) and any grade thrombocytopenia (OR: 0.53, 95% CI: 0.35-0.80) were observed in the 5-FU bolus group. No significant differences were found for other toxicities like febrile neutropenia, diarrhea, or nausea.ConclusionsThis meta-analysis demonstrates that the omission of 5-FU bolus from the commonly used 5-FU-based chemotherapy regimens in gastrointestinal cancers, with the use of only 5-FU infusion, may reduce the risk of hematologic toxicities such as neutropenia and thrombocytopenia without affecting survival outcomes in metastatic gastrointestinal cancers.Protocol registrationwww.crd.york.ac.uk/prospero identifier is CRD42024602968.Öğe The effect of the horizontal vs. vertical PAPE protocol on the swim start performance in adolescent male(Routledge Journals, Taylor & Francis Ltd, 2025) Ogul, Begum; Uslu, Serkan; Hindistan, Ibrahim Ethem; Akdag, Eren; Özdogan, Emel CetinPost-activation performance enhancement (PAPE) is referred to enhancement in muscular performance due to high-intensity voluntary contractions. This study aimed to examine the effect of the horizontal vs. vertical PAPE protocol on the start performance in swimming. Sixteen swimmers (age: 13.71 +/- 0.95 years; height: 169.43 +/- 9.68 cm; body mass: 58.47 +/- 7.64 kg) performed three warm-up protocols: (i) a swim-specific warm-up (SWU); (ii) back squat (BS) followed SWU (SWUB); (iii) barbell hip thrust (BHT) followed SWU (SWUH) which consisted of 1 set of 3 reps at 80% 1RM. Rest times are evaluated individually. The findings of this study indicate that SWUB has no beneficial effect on any phase in all examined parameters, while SWUH has a slight improvement only in the take-off phase compared to SWUB (p < 0.05). BHT is better compared to BS as a PAPE stimulus for swimming, but there is no positive effect on 50 m swimming time compared to SWU (p > 0.05). In conclusion, to the best of our knowledge, the effect of BHT as a PAPE stimulus was investigated for swimming for the first time, but results show that neither BS nor BHT has a positive effect on 50 m swimming performance.Öğe Role of VEGF I/D variant in suspectibility to odontogenic cyst formation(Taylor & Francis Inc, 2023) Yildiz, Serkan; Nursal, Ayse Feyda; Yigit, Serbulent; Tumer, Mehmet KemalOdontogenic cysts, are located in the jawbones, filled with fluid surrounded by epithelial lining and fibrous connective tissue. Vascular endothelial growth factor (VEGF) can induce physiological and pathological angiogenesis and is an endothelial cell-specific mitogen. The aim of the present study was to investigate whether any possible association between the VEGF insertion/deletion (I/D) variant and odontogenic cyst in Turkish population. Clinical information and venous blood samples were collected from 62 odontogenic cyst patients and 98 healthy controls. DNA was isolated from peripheral blood leukocytes. Genotyping of the VEGF I/D variant was done by the polymerase chain reaction (PCR) method. There was a statistically differece in terms of VEGF I/D allele frequencies between patients and controls. VEGF I/D variant I allele frequency was more prevalant in patients compared to controls (p = 0.006411, OR: 2.08, 95%Cl: 1.322-3.272). A statistically significant association was observed when the patients were compared with the controls according to D/D + I/D versus I/I genotype (p = 0.0508, OR: 1.925, 95%Cl: 0.872-4.246). The genotype distribution of VEGF I/D was not statistically different between patients and controls (p > 0.05). For the first time, our results provided evidence supporting the odontogenic cyst formation associated with the I/D variant at the promoter region of the VEGF gene in a group of Turkish population. Although it was seen in our study that the I/D variant in the promoter region of the VEGF gene supports odontogenic cyst formation, large-scale studies are needed to elucidate the effect of this variant on odontogenic cysts.Öğe Adrenergic receptor behaviors of mesenchymal stem cells obtained from different tissue sources and the effect of the receptor blockade on differentiation(Taylor & Francis Ltd, 2022) Maytalman, Erkan; Alizadeh Yegani, Arash; Kozanoglu, Ilknur; Aksu, FaziletIn this study, it was aimed to analyze behavioral changes of adrenergic receptors (ARs) in first three passages and osteogenic/adipogenic differentiation of mesenchymal stem cells (MSCs) derived from placenta fetal membrane (FM) and bone marrow (BM). It was also aimed to evaluate effects of receptor blockade on differentiation. We obtained first three passages of MSCs from placenta and BM samples. For cell identification, the cells were analyzed by flow cytometry using CD34, CD45 and CD3, CD105 antibodies in each passage. The effects of propranolol and phenoxybenzamine at incremental doses were analyzed by MTT. In addition, cell cultures were separately maintained with the blockers or without after second passage. After each passage and differentiation, alpha 1A, alpha 1B, alpha 2A, alpha 2B, beta 1, beta 2, beta 3 AR-mRNA expressions analyzed by RT-qPCR technique. BMP6 and PPARG mRNA expressions only after differentiation and passage 3 were analyzed. A microscopic examination was also performed. Our results showed that AR expression behaviors were different in MSCs obtained from different tissue sources. In particular, alpha(1A)-AR and alpha(2A)-AR were expressed with considerably high coefficients in differentiation under blocker effect in BM-derived MSCs. No such coefficients were observed in any group of placental MSCs. In addition, it was found that the blockers stimulated adipogenesis in BM-derived MSCs during osteogenic differentiation. MSCs exhibit protein expressions that vary according to source of tissue and differentiation. Given that MSCs from different sources are used for repair and modulation, our study makes implications of this variable expression intriguing in the clinical practice.Öğe Could the Valsalva manoeuvre be an alternative to the tenaculum for intrauterine device insertion?(Taylor & Francis Ltd, 2021) Cimsir, Meral Tugba; Yildiz, Muhammet SerhatObjectives This study investigated whether the Valsalva manoeuvre (VM) could be an alternative to use of the tenaculum for intrauterine device (IUD) insertion. The aims were to establish whether VM could provide good patient comfort and enable the insertion to be performed successfully with adequate pain control in cases where the cervix could not be passed spontaneously. Methods Women who attended the outpatient clinic of Alanya Education and Research Hospital between November 2017 and December 2020 for IUD insertion were randomly assigned to the VM (n = 52) or tenaculum (n = 55) group. Insertion in the latter group was carried out by grasping the cervix with a single-toothed tenaculum. In the VM group, no tenaculum was used to grasp the cervix; instead, the woman was asked to perform VM during insertion. Results IUD insertion success rates were similar between the groups. Procedural anxiety scores were slightly higher in the tenaculum group. Pain scores measured during the procedure were significantly higher in the tenaculum group compared with the VM group. Severe pain was reported by 58.2% of women in the tenaculum group, whereas 57.7% of women in the VM group reported no pain. Conclusion In cases where an IUD cannot be passed through the cervical canal spontaneously, the procedure should be attempted using VM before using a tenaculum. The use of VM may lead to lower pain and anxiety levels as well as increased patient comfort.Öğe Efficacy of first-line CDK 4-6 inhibitors in premenopausal patients with metastatic breast cancer and the effect of dose reduction due to treatment-related neutropenia on efficacy: a Turkish Oncology Group (TOG) study(Taylor & Francis Ltd, 2025) Yildirim, Hasan Cagri; Kapar, Caner; Koksal, Baris; Seyyar, Mustafa; Sanci, Pervin Can; Guliyev, Murad; Perkin, PerihanThe only phase 3 study on the effectiveness of CDK 4-6 inhibitors in first-line treatment in premenopausal patients with hormone receptor (HR) positive, HER2 negative metastatic breast cancer is the MONALEESA-7 study, and data on the effectiveness of palbociclib is limited. Data are also limited regarding the effectiveness of CDK 4-6 inhibitors in patients whose dose was reduced due to neutropenia, the most common side effect of CDK 4-6 inhibitors. In our study, we aimed to evaluate the effectiveness of palbociclib and ribociclib in first-line treatment in patients with premenopausal metastatic breast cancer and the effect of dose reduction due to neutropenia on progression-free survival. Our study is a multicenter, retrospective study, and factors affecting progression-free survival (PFS) were examined in patients diagnosed with metastatic premenopausal breast cancer from 29 different centers and receiving combination therapy containing palbociclib or ribociclib in the metastatic stage. 319 patients were included in the study. The mPFS for patients treated with palbociclib was 26.83 months, and for those receiving ribociclib, the mPFS was 29.86 months (p = 0.924). mPFS was 32.00 months in patients who received a reduced dose, and mPFS was 25.96 months in patients who could take the initial dose, and there was no statistical difference (p = 0.238). Liver metastasis, using a fulvestrant together with a CDK 4-6 inhibitor, ECOG PS 1 was found to be a negative prognostic factor. No new adverse events were observed. In our study, we found PFS over 27 months in patients diagnosed with premenopausal breast cancer with CDK 4-6 inhibitors used in first-line treatment, similar to post-menopausal patients. We did not detect any difference between the effectiveness of the two CDK 4-6 inhibitors, and we showed that there was no decrease in the effectiveness of the CDK 4-6 inhibitor in patients whose dose was reduced due to neutropenia.Öğe The relationship between workplace toxicity, stress, physical activity and emotional eating(Taylor & Francis Ltd, 2024) Unguren, Engin; Tekin, Omer AkgunThis study examines the relationship between perceived workplace toxicity and stress of employees in the hospitality industry and emotional eating behaviors within the context of their physical activity levels. A cross-sectional design from amongst the quantitative research methods was used, in which data were collected via questionnaires from 846 participants who work in five-star hotels in Alanya, Turkey. The study concluded that workplace toxicity positively predicts stress and emotional eating, and the impact of workplace toxicity on emotional eating occurs via stress. Furthermore, physical activity plays a moderating role in the effect of workplace toxicity and stress on emotional eating. As employees' physical activity levels drop, the effect of both stress and workplace toxicity on emotional eating significantly increases. These results reveal that physical activity buffers the negative effects of workplace toxicity and stress on emotional eating.Öğe Recent progress in chitosan-based nanoparticles for drug delivery: a review on modifications and therapeutic potential(Taylor & Francis Ltd, 2025) Bal, Kevser; Celik, Sibel Kucukertugrul; Senturk, Sema; Kaplan, Ozlem; Eker, Emine Busra; Gok, Mehmet KorayChitosan, obtained from chitin by deacetylation, is a versatile biopolymer known for its biocompatibility, biodegradability and environmental friendliness. Combined with its chemical and physical modifiability, these properties have made chitosan an important material in biomedical and pharmaceutical fields, especially in drug delivery systems. Chitosan-based nanomaterials exhibit enhanced functions through various chemical modifications such as thiolation, acetylation, carboxylation and phosphorylation, as well as through physical and enzymatic approaches. These modifications address inherent limitations such as poor solubility, limited acid resistance and insufficient mechanical strength, expanding the applications of chitosan in tissue engineering, gene therapy, vaccine delivery, wound healing and bioimaging. This review provides an in-depth analysis of the chemical structure, physicochemical properties and modification strategies of chitosan. It also explores current methodologies for preparing chitosan nanoparticles, along with drug loading and release techniques. Various targeting strategies employed in chitosan-based delivery systems are examined in detail. To illustrate the clinical relevance of these approaches, representative examples from recent therapeutic studies are included. Moreover, it highlights future research directions and the innovation potential of chitosan-based materials.Öğe The increased chromosomal DNA damage in patients with Familial Mediterranean Fever(Taylor & Francis Ltd, 2024) Kiraz, Aslihan; Eciroglu, Hamiyet; Altin-Celik, Pinar; Donmez-Altuntas, HamiyetFamilial Mediterranean Fever (FMF) is an inherited autoinflammatory disease. In this study, we aimed to assess chromosomal DNA damage and cell proliferation by using cytokinesis-block micronucleus cytome (CBMN-cyt) assay in the peripheral blood lymphocytes of untreated FMF patients carrying M694V and R202Q mutations, which are the most common MEFV gene mutations in Turkish society. The study included 20 untreated FMF patients with M694V and R202Q mutations and 20 healthy individuals of similar age and sex as the control group. Micronucleus (MN), nucleoplasmic bridges (NPBs), and nuclear buds (NBUDs) were scored in the obtained bi-nucleated (BN) cells. Additionally, the nuclear division index (NDI) was calculated using the scores of mononuclear, binuclear, and multinuclear cells. We found that MN and NPBs frequencies in FMF patients were significantly higher than in controls, and number of metaphases was significantly lower (respectively, p < 0.05, p < 0.01, and p < 0.01). However, there was no significant difference in NBUDs frequencies and NDI values between FMF patients and controls (p > 0.05). Our study is the first to evaluate FMF patients' lymphocytes using the CBMN-cyt assay, as no previous research has been found in this respect. Increased MN and NPB frequencies may be useful as biomarkers for chromosomal DNA damage, and may indicate a potential for elevated cancer risk in untreated FMF patients.Öğe Social Participation of Older Adults in Rural and Urban Areas: A Cross-Sectional Survey in Turkey(Routledge Journals, Taylor & Francis Ltd, 2025) Yilmaz, Medine; Uyanik, Gulcin; Kundakci, Gamze Agartioglu; Baybuga, Media Subasi; Altay, Birsen; Cingil, Dilek; Bakan, Ayse BerivanSocial participation is important in terms of active aging and quality of life during old age. This cross-sectional study aimed to determine the social participation of older adults in rural and urban areas in Turkey. Related factors were similarly identified. The sample comprised 1,224 people over the age of 60, with a mean of 69.78 +/- 7.48 years. Among the participants, 61.4% live in urban areas. The data were collected in family health centers through face-to-face interview and the Interview Form, Social Participation Assessment Form, and Social Participation Dimension of the Turkish Version of the Aging Module of the World Health Organization Quality of Life (WHOQOL) Scale. The scores obtained from the social participation dimension of the scale among the elderly in urban areas were higher than those obtained among the elderly in rural areas (p = .002). In addition, older adults in the urban areas who talked on the phone several times a month (p = .025), went to concerts, theater/cinema, museum/exhibition, various visual/musical shows (p = .046), and engaged in gardening (p = .032) obtained higher scores in the social participation dimension than the other participants. Health care professionals should take an advocacy role in building relationships with policy makers and create suitable socialization opportunities for older adults in urban and rural areas. Social participation is important in terms of active aging and quality of life during old age.This is the first study with a huge sample to compare the level of social participation of the elderly in rural and urban areas in Turkey.It provides information on the level of social participation of the elderly in a developing country.Öğe A histological examination of the effects of Ferula elaeochytris extract on kidney and liver tissues in myoglobinuric acute renal failure(Taylor & Francis Ltd, 2024) Yildiz, Fatma; Gungor, Meltem; Sezginer, Perihan; Aksak, TiinceMyoglobinuric acute renal failure (MARF) is a structural and functional disorder that occurs in the kidney following the release of muscle cell contents into the circulation. In this present study, possible protective and curative effects of Ferula elaeochytris extract against kidney and liver damage in experimentally induced MARF in a rat model were investigated. 3-4 Month-old, 200-250 g Sprague Dawley rats were divided into 8 equal groups with 7 rats per group. Group I was a no-intervention Control group. All groups except for the Group I were dehydrated for 16 hours. Following this dehydration, 50% v/v aqueous glycerol solution was injected into both hind leg muscles of the animals, at a dose of 8 ml/kg. The rats were given physiological saline (SF) once orally before the model was administered (Group II) and after the model was administered (Group V). Similarly, two different doses of Ferula elaeochytris root extract (40 mg/kg and 80 mg/kg) were dissolved in 2 ml of SF and administered orally before (Groups III and IV) and after (Group VI, VII) the model was created. Following the experimental period, kidney and liver tissues were removed from all groups, and fixed in 10% neutral formaldehyde solution for light microscopic examinations. Intracellular vacuolization, enlargement in the Bowman's space, widespread atrophy in the tubular structures, luminal enlargement, and desquamation were detected in the kidney tissue sections of all the experimental model groups. In the liver tissue sections, was detected hepatocyte degeneration, intracellular vacuolization, irregularity in cell membrane borders, and apoptotic bodies. These histopathological consequences of MARF were evaluated for all groups, and whereas a curative effect of Ferula elaeochytris could be seen, its protective effect was higher than its curative effect.Öğe Effects of propolis coating on antibacterial resistance of intrauterine devices(Taylor & Francis Ltd, 2024) Deniz, Alparslan; Karasu, Tunca; Idil, Neslihan; Uzun, LokmanIntrauterine devices (IUDs) are widely used in preventing fertilization as contracepting devices. In market, they are produced as T-shaped polyethylene (or propylene) and metal (especially copper) composites. Although the metal component is utilized to provide antibacterial efficacy, prolonged implantation and the presence of a wide range of bacteria flora in the intrauterine environment make IUDs susceptible to bacterial contamination, biofilm formation, and unpleasant infection. In the presented study, the propolis, a natural anti-bacterial/-viral product used for different biomedical applications, coating strategy was applied comparatively in three different ways: coating directly on metal components, coating on polymeric material, and using carrying polymer. In addition, antibacterial activity against Gram-positive (Staphylococcus aureus, S. aureus) and Gram-negative (Escherichia coli, E. coli) bacterial strains were investigated by both dynamic bacterial culture (bacterial inhibition activity) and biofilm (biofilm formation resistance) tests. As a result of 48 h of dynamic bacterial culture; it was determined that the antibacterial inhibition efficiency depending on propolis concentration increased up to 99.5% and 98.5% for E. coli and S. aureus, respectively. In addition, the carrying polymer allows IUDs to cover surfaces more homogeneously, as well as improve antibacterial activity. Similarly; it was determined that biofilm formation resistance was improved by 44.33% for E. coli and by 45.99% for S. aureus with both the propolis concentration and the use of carrying polymer. As a result, it has been revealed that propolis will be classified as an alternative, promising, and effective coating agent for improving antibacterial properties and biofilm formation resistance of IUDs.Öğe Chronotype is associated with Mediterranean dietary adherence and environmental footprints(Taylor & Francis Ltd, 2024) Memic-Inan, Cansu; Sarahman-Kahraman, Ceren; Ozcelik, Ayse Ozfer; Yabanci-Ayhan, NurcanThis cross-sectional study was carried out to determine the relationship between nutrition according to chronotype and the Mediterranean diet and environmental footprints. Morningness Eveningness Questionnaire was used to determine the chronotype classification, and Mediterranean Diet Adherence Screener was used to evaluate adherence to the Mediterranean diet. In addition, the food consumption record of the participants was taken and the carbon and water footprints were calculated. A total of 472 adults with a mean age of 22.7 +/- 5.0 years participated in the study. Accordingly, 61.0% of the participants were morning type, 15.7% were intermediate type, and 23.3% were evening type. Individuals with higher chronotype values (morning) tended to be more adherent to the Mediterranean diet and had lower environmental (carbon and water) footprints (p < 0.05). The results of this study; showed that diet according to chronotype affects adherence to the Mediterranean diet and environmental footprints.
