The relationship between oral cancer and cadmium: a review
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Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Cadmium (Cd) has been classifed as a type I carcinogen. Since it is ingested orally through food and tobacco use, Cd is likely to be closely related to oral cancers. The relationship between cadmium and oral cancer was investigated using papers on Pubmed and Web of Science. Thus a total of 11 studies from these databases were included in the review. Cd concentrations were signifcantly higher in both the blood and hair of oral cancer patients than in controls. Additionally, it has been reported that Cd increases the activity of reactive oxygen species. Tobacco plants contain varying levels of Cd. The presence of high Cd concentrations in patients who use tobacco products and develop oral cancer is strong evidence that Cd is directly related to oral cancer. While planning a study to determine the Cd concentrations in biological samples, it is advisable to examine the methodologies of previous studies and to avoid technical defciencies. New cell line studies are required to explain the relationship between Cd and autophagy-apoptosis.
Açıklama
Anahtar Kelimeler
Cadmium, Oral cancer, Oral squamous cell carcinoma, Autophagy
Kaynak
Molecular Biology Reports
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
49
