Effect of Repetitive Transcranial Magnetic Stimulation on Neurocognitive Functions in Moderate and Severe Depression: A Longitudinal Study

Basit Öğe Kaydı
dc.contributor.authorKavak Sinanoglu, Gokce
dc.contributor.authorGuler, Ozkan
dc.contributor.authorCalis, Zeynep
dc.date.accessioned2026-01-24T12:26:44Z
dc.date.available2026-01-24T12:26:44Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjective: We aimed to investigate the effects of transcranial magnetic stimulation (TMS) on depressive symptoms and neurocognitive functions during treatment and follow-up. Methods: A total of 65 patients diagnosed with major depressive disorder, with a >16 scores in Hamilton Depression Rating Scale (Ham-D) and a >18 scores in Beck Depression Inventory (BDI), participated in the study. The Ham-D, BDI, Beck Anxiety Inventory (BAI), Trail Making Tests A and B, Stroop Colour and Word Test, Number Sequence Test, & Ouml;ktem Verbal Memory Processes Test, and Verbal Fluency Test were administered at baseline, 1st-, and 3rd-month for both treatment and control groups. Results: A total of 65 patients were enrolled in the study, of whom 25 in the TMS group and 26 in the non-TMS group completed the follow-up. At the first month, 73.5% of patients in the TMS group showed a full treatment response, compared to 29.03% in the non-TMS group (p=0.001). At the third month, the treatment response rate decreased to 40% in the TMS group, whereas it was 42.3% in the non-TMS group, and the significant difference between the groups disappeared (p=0.918). In terms of cognitive functions, no significant changes were observed in either group at the first- and third-month follow-ups compared to baseline. Conclusion: TMS had a strong acute antidepressant effect; however, this effect diminished over time during the follow-up period. Although partial improvement was observed in cognitive functions, this improvement did not reach statistical significance.
dc.identifier.doi10.5080/u27539
dc.identifier.endpage449
dc.identifier.issn1300-2163
dc.identifier.pmid41070508
dc.identifier.scopus2-s2.0-105017785120
dc.identifier.scopusqualityQ3
dc.identifier.startpage439
dc.identifier.urihttps://doi.org/10.5080/u27539
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4882
dc.identifier.volume36
dc.identifier.wosWOS:001560833300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkiye Sinir Ve Ruh Sagligi Dernegi
dc.relation.ispartofTurk Psikiyatri Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectCognitive functions
dc.subjectmajor depressive disorder
dc.subjecttranscranial magnetic stimulation
dc.titleEffect of Repetitive Transcranial Magnetic Stimulation on Neurocognitive Functions in Moderate and Severe Depression: A Longitudinal Study
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu