Effect of Repetitive Transcranial Magnetic Stimulation on Neurocognitive Functions in Moderate and Severe Depression: A Longitudinal Study
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Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkiye Sinir Ve Ruh Sagligi Dernegi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: We aimed to investigate the effects of transcranial magnetic stimulation (TMS) on depressive symptoms and neurocognitive functions during treatment and follow-up. Methods: A total of 65 patients diagnosed with major depressive disorder, with a >16 scores in Hamilton Depression Rating Scale (Ham-D) and a >18 scores in Beck Depression Inventory (BDI), participated in the study. The Ham-D, BDI, Beck Anxiety Inventory (BAI), Trail Making Tests A and B, Stroop Colour and Word Test, Number Sequence Test, & Ouml;ktem Verbal Memory Processes Test, and Verbal Fluency Test were administered at baseline, 1st-, and 3rd-month for both treatment and control groups. Results: A total of 65 patients were enrolled in the study, of whom 25 in the TMS group and 26 in the non-TMS group completed the follow-up. At the first month, 73.5% of patients in the TMS group showed a full treatment response, compared to 29.03% in the non-TMS group (p=0.001). At the third month, the treatment response rate decreased to 40% in the TMS group, whereas it was 42.3% in the non-TMS group, and the significant difference between the groups disappeared (p=0.918). In terms of cognitive functions, no significant changes were observed in either group at the first- and third-month follow-ups compared to baseline. Conclusion: TMS had a strong acute antidepressant effect; however, this effect diminished over time during the follow-up period. Although partial improvement was observed in cognitive functions, this improvement did not reach statistical significance.
Açıklama
Anahtar Kelimeler
Cognitive functions, major depressive disorder, transcranial magnetic stimulation
Kaynak
Turk Psikiyatri Dergisi
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
36
