Prognostic Factors For Functional Outcome in Patients with Mesencephalic Hemorrhage

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dc.authorid0000-0002-2901-9843
dc.contributor.authorOktem, Ece Ozdemir
dc.contributor.authorKumral, Emre
dc.contributor.authorBayam, Fatma Ece
dc.contributor.authorOzsimsek, Ahmet
dc.contributor.authorDorukoglu, Mehmet Mesut
dc.contributor.authorCankaya, Seyda
dc.contributor.authorYulug, Burak
dc.date.accessioned2026-01-24T12:29:26Z
dc.date.available2026-01-24T12:29:26Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractIntroduction: Mesencephalic hemorrhage (MH) is a rare presentation of spontaneous intraparenchymal hemorrhage. This study aims to evaluate prognostic parameters of the MH outcome. Methods: We conducted an extensive search in the literature for cases with spontaneous, isolated mesencephalic hemorrhage. The study was conducted according to the statement of Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Sixty-two eligible cases have been reported in the literature as proven by CT or MRI, and to these, we added six cases confirmed by MRI. The modified Rankin Scale (mRS) was dichotomized into two groups as the favorable outcome (FO; score, 0-2) and unfavorable outcome (UO; score, 3-6). Results: Of the 68 patients studied, 26 (38%) presented with normal consciousness, 22 (32%) with lethargy, and 20 (29%) with stupor or coma. There was no cause of hemorrhage in 26 (65%) patients with FO and 12 (43%) with UO (p=0.059). In univariate analyses, neither arteriovenous malformations (p=0.33) nor cavernomas (p=0.19) were associated with outcome. Multiple logistic regression analysis revealed that hypertension (OR, 51.22; CI95%, 1.92-1370.24; P=0.019), consciousness (OR, 133.54; CI95%, 1.61-1113.3; P=0.03), NIHSS at admission (OR, 57.23; CI95%, 2.87-1141.2; p=0.008), and ventrodorsal hemorrhage size (=1 cm) (OR, 61.83; CI95%, 2.15-1779.2; p=0.016) were significantly associated with UO. Three months after stroke, 40 patients (59%) had FO, 28 (41%) had UO, and 8 (12%) died. Conclusion: These results suggest that ventrodorsal size of hemorrhage and clinical severity at stroke onset are possible predictors of functional outcome after mesencephalic hemorrhage.
dc.identifier.doi10.29399/npa.28244
dc.identifier.endpage16
dc.identifier.issn1300-0667
dc.identifier.issn1309-4866
dc.identifier.issue1
dc.identifier.pmid36911557
dc.identifier.scopus2-s2.0-85151022527
dc.identifier.scopusqualityQ3
dc.identifier.startpage9
dc.identifier.trdizinid1169756
dc.identifier.urihttps://doi.org/10.29399/npa.28244
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1169756
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5336
dc.identifier.volume60
dc.identifier.wosWOS:001190959500016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi
dc.relation.ispartofNoropsikiyatri Arsivi-Archives of Neuropsychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectMesencephalic hemorrhage
dc.subjectbrainstem hemorrhage
dc.subjectpredictive parameters
dc.subjectmodified rankin scale
dc.titlePrognostic Factors For Functional Outcome in Patients with Mesencephalic Hemorrhage
dc.title.alternativeMezensefalik Kanamalı Hastalarda Fonksiyonel Sonuçlara Yönelik Prognostik Faktörler
dc.typeArticle

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