Experimental investigation of proangiogenic properties of sacubitril on a chorio allantoic membrane model

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dc.authorid0000-0003-3432-4946
dc.contributor.authorOzgul, Mustafa
dc.contributor.authorAydogan, Eyup
dc.date.accessioned2026-01-24T12:29:09Z
dc.date.available2026-01-24T12:29:09Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBackground: Sacubitril is an important and effective agent for cardiovascular remodeling. This study aims to evaluate its proangiogenic effects in an experimental model. Methods: The chorioallantoic membrane (CAM) model was created for the investigation of the proangiogenic potential of sacubitril with different therapeutic doses (10(-7) M, 10(-6) M, 10(-5) M) and compared with drug-free pellet group (sham) and normal morphology (control) of chick embryo development in drug-free chick embryos. The developing embryo's vascularity and the pellets' effect were evaluated under a stereoscopic microscope. The density of vascular shoots and newly formed vascular nodules were not recorded. Results: There was no significant difference between the control and drug-free pellet groups (12.4 +/- 2.8 vs. 14.1 +/- 1.3 junctions per ROI, p = 0.48). The incremental angiogenic properties were detected in drug groups as follows: 15.3 +/- 3.8 per ROI in Group I (10(-7) M concentration); 21.6 +/- 5.4 per ROI in Group II (10(-6) M concentration); 22.9 +/- 8.1 per ROI in Group III (10(-5) M concentration) (p < 0.001). Conclusion: Our findings support that sacubitril provokes angiogenesis in a dose-dependent manner. Investigating these properties can be useful for understanding further effects of this agent in other cardiovascular diseases. Therapeutic angiogenesis is important for ameliorating the results.
dc.identifier.doi10.1177/13860291251352350
dc.identifier.endpage121
dc.identifier.issn1386-0291
dc.identifier.issn1875-8622
dc.identifier.issue3
dc.identifier.pmid40624986
dc.identifier.scopus2-s2.0-105014130065
dc.identifier.scopusqualityQ2
dc.identifier.startpage116
dc.identifier.urihttps://doi.org/10.1177/13860291251352350
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5140
dc.identifier.volume90
dc.identifier.wosWOS:001524180600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofClinical Hemorheology and Microcirculation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectSacubitril
dc.subjectangiogenesis
dc.subjectCAM model
dc.subjectremodeling
dc.titleExperimental investigation of proangiogenic properties of sacubitril on a chorio allantoic membrane model
dc.typeArticle

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