Experimental investigation of proangiogenic properties of sacubitril on a chorio allantoic membrane model
[ X ]
Tarih
2025
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sage Publications Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Sacubitril is an important and effective agent for cardiovascular remodeling. This study aims to evaluate its proangiogenic effects in an experimental model. Methods: The chorioallantoic membrane (CAM) model was created for the investigation of the proangiogenic potential of sacubitril with different therapeutic doses (10(-7) M, 10(-6) M, 10(-5) M) and compared with drug-free pellet group (sham) and normal morphology (control) of chick embryo development in drug-free chick embryos. The developing embryo's vascularity and the pellets' effect were evaluated under a stereoscopic microscope. The density of vascular shoots and newly formed vascular nodules were not recorded. Results: There was no significant difference between the control and drug-free pellet groups (12.4 +/- 2.8 vs. 14.1 +/- 1.3 junctions per ROI, p = 0.48). The incremental angiogenic properties were detected in drug groups as follows: 15.3 +/- 3.8 per ROI in Group I (10(-7) M concentration); 21.6 +/- 5.4 per ROI in Group II (10(-6) M concentration); 22.9 +/- 8.1 per ROI in Group III (10(-5) M concentration) (p < 0.001). Conclusion: Our findings support that sacubitril provokes angiogenesis in a dose-dependent manner. Investigating these properties can be useful for understanding further effects of this agent in other cardiovascular diseases. Therapeutic angiogenesis is important for ameliorating the results.
Açıklama
Anahtar Kelimeler
Sacubitril, angiogenesis, CAM model, remodeling
Kaynak
Clinical Hemorheology and Microcirculation
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
90
Sayı
3
