Altered thiol/disulfide homeostasis in patients with diabetes mellitus and its chronic complications

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dc.contributor.authorAslanoglu, Nuri
dc.contributor.authorKeskek, Sakir Ozgur
dc.contributor.authorNeselioglu, Salim
dc.contributor.authorEren, Funda
dc.date.accessioned2026-01-24T12:29:19Z
dc.date.available2026-01-24T12:29:19Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjective: To evaluate the effect of diabetes mellitus and its chronic complications on thiol/disulfide homeostasis. Methods: The study included 381 participants divided into six groups: healthy controls (Group 1; n = 91), patients with prediabetes (Group 2; n = 50), patients with diabetes mellitus without complications (Group 3; n = 70), patients with diabetic retinopathy (Group 4; n = 47), patients with diabetic nephropathy (Group 5; n = 70), and patients with diabetic foot (Group 6; n = 53). Thiol/disulfide homeostasis was determined by measuring the reduction reaction of oxidized thiols. Results: Native thiol levels were low in patients with diabetes mellitus complications (Group 4, 264.7 +/- 58.5 mu mol/L; Group 5, 246.6 +/- 67.5 mu mol/L; Group 6, 174.3 +/- 65.9 mu mol/L), as were total thiol levels. The highest and lowest disulfide levels were observed in Group 1(controls; 20.4 +/- 5.2 mu mol/L) and Group 6 (16.2 +/- 5.7 mu mol/L), respectively. The disulfide/native thiol ratio was increased in Groups 4, 5, and 6 compared with Groups 1, 2, and 3. Conclusion: The presence of diabetes mellitus complications substantially decreased native thiol, total thiol, and disulfide levels.
dc.identifier.doi10.20945/2359-4292-2025-0042
dc.identifier.issn2359-3997
dc.identifier.issn2359-4292
dc.identifier.issue5
dc.identifier.pmid41004664
dc.identifier.scopus2-s2.0-105017415008
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.20945/2359-4292-2025-0042
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5281
dc.identifier.volume69
dc.identifier.wosWOS:001602231900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSbem-Soc Brasil Endocrinologia & Metabologia
dc.relation.ispartofArchives of Endocrinology Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectDisulfides
dc.subjectHomeostasis
dc.subjectDiabetic angiopathies
dc.subjectPrediabetic state
dc.subjectBiomarkers
dc.titleAltered thiol/disulfide homeostasis in patients with diabetes mellitus and its chronic complications
dc.typeArticle

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