Altered thiol/disulfide homeostasis in patients with diabetes mellitus and its chronic complications
[ X ]
Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sbem-Soc Brasil Endocrinologia & Metabologia
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: To evaluate the effect of diabetes mellitus and its chronic complications on thiol/disulfide homeostasis. Methods: The study included 381 participants divided into six groups: healthy controls (Group 1; n = 91), patients with prediabetes (Group 2; n = 50), patients with diabetes mellitus without complications (Group 3; n = 70), patients with diabetic retinopathy (Group 4; n = 47), patients with diabetic nephropathy (Group 5; n = 70), and patients with diabetic foot (Group 6; n = 53). Thiol/disulfide homeostasis was determined by measuring the reduction reaction of oxidized thiols. Results: Native thiol levels were low in patients with diabetes mellitus complications (Group 4, 264.7 +/- 58.5 mu mol/L; Group 5, 246.6 +/- 67.5 mu mol/L; Group 6, 174.3 +/- 65.9 mu mol/L), as were total thiol levels. The highest and lowest disulfide levels were observed in Group 1(controls; 20.4 +/- 5.2 mu mol/L) and Group 6 (16.2 +/- 5.7 mu mol/L), respectively. The disulfide/native thiol ratio was increased in Groups 4, 5, and 6 compared with Groups 1, 2, and 3. Conclusion: The presence of diabetes mellitus complications substantially decreased native thiol, total thiol, and disulfide levels.
Açıklama
Anahtar Kelimeler
Disulfides, Homeostasis, Diabetic angiopathies, Prediabetic state, Biomarkers
Kaynak
Archives of Endocrinology Metabolism
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
69
Sayı
5
