Nicotinamide Riboside Preserves Ovarian Injury in an Experimental Sepsis Model in Rats

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dc.authorid0000-0001-7740-8248
dc.contributor.authorSelli, Jale
dc.contributor.authorKeles, Dilek Vural
dc.contributor.authorKeles, Osman Nuri
dc.contributor.authorCelik, Muhammet
dc.contributor.authorYetim, Zeliha
dc.date.accessioned2026-01-24T12:26:44Z
dc.date.available2026-01-24T12:26:44Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjective: The aim of the study is to investigate the protective effects of nicotinamide riboside on oxidative stress in an experimental sepsis model created by cecal ligation and puncture. Materials and Methods: Rats were divided into 3 groups randomly: sham-operated (control) group, sepsis group, and nicotinamide riboside-treated group. Sepsis model-induced cecal ligation and puncture was applied to sepsis group rats. Animals in the nicotinamide riboside-treated group were administered nicotinamide riboside intraperitoneally (500 mg/kg). Tissue specimens from rats were biochemically calculated for their activities of catalase, superoxide dismutase, glutathione peroxidase, myeloperoxidase, and malondialdehyde levels. Ovarian tissues of all rats were histopathologically evaluated. Results: Catalase, superoxide dismutase, and glutathione peroxidase activities were lower in the sepsis group compared to the sham-operated (control) group. Superoxide dismutase activity was significantly higher in the nicotinamide riboside-treated group than in control and sepsis group (P < .05). Myeloperoxidase activities and mean malondialdehyde concentration of ovarian tissue were lower in nicotinamide riboside-treated group than in sepsis group (P < .05). The light microscopic assessment revealed that ovarian tissue was protected, and inflammation and interstitial edema decreased in nicotinamide riboside-treated group. The follicular damage findings were notably decreased in nicotinamide riboside-treated group in comparison to sepsis group (P<0.05). Conclusion: Our findings indicated that nicotinamide riboside diminished ovarian injury in sepsis via inhibiting tissue infiltration and increasing endogenous antioxidant capacity. Nicotinamide riboside administration may represent a new treatment approach for the prevention of sepsis-induced ovarian injury.
dc.identifier.doi10.5152/eurasianjmed.2023.22255
dc.identifier.endpage134
dc.identifier.issn1308-8742
dc.identifier.issue2
dc.identifier.pmid36648023
dc.identifier.scopus2-s2.0-85169148770
dc.identifier.scopusqualityQ2
dc.identifier.startpage128
dc.identifier.trdizinid1188010
dc.identifier.urihttps://doi.org/10.5152/eurasianjmed.2023.22255
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1188010
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4889
dc.identifier.volume55
dc.identifier.wosWOS:001029581000007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAves
dc.relation.ispartofEurasian Journal of Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectNicotinamide riboside
dc.subjectovarian injury
dc.subjectoxidative stress
dc.subjectsepsis
dc.titleNicotinamide Riboside Preserves Ovarian Injury in an Experimental Sepsis Model in Rats
dc.typeArticle

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