Viral Respiratory Tract Infection Agents Detected Between Years 2019-2021, COVID-19, and Co-Infections

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dc.authorid0000-0003-2203-3156
dc.authorid0000-0003-0959-9091
dc.authorid0000-0001-8318-2556
dc.contributor.authorAydogan, Sibel
dc.contributor.authorKirca, Fusun
dc.contributor.authorGozalan, Ayeguel
dc.contributor.authorToyran, Alparslan
dc.contributor.authorBasyigit, Tugcan
dc.contributor.authorOmay, Ipek
dc.contributor.authorDinc, Bedia
dc.date.accessioned2026-01-24T12:26:46Z
dc.date.available2026-01-24T12:26:46Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractRespiratory tract infections are a major cause of morbidity and mortality at all ages and are seen as a very important public health problem all over the world. In this study, we aimed to evaluate the effect of the pandemic on the epidemiological and seasonal characteristics of the agents by analyzing the respiratory viral infection agents, viral co-infections and associations with Coronavirus diseases-2019 (COVID-19) studied by multiplex polymerase chain reaction (PCR) test in the molecular microbiology laboratory in a three-year period, including the one-year period before the pandemic. Between March 2019 and December 2021, 8825 respiratory tract specimens accepted to the molecular microbiology laboratory with respiratory tract multiplex PCR test requests were included in the study. In addition, severe acute respiratory syndrome (SARS-CoV-2) PCR test results of the patients with positive results with respiratory tract multiplex PCR test, which were studied within +/- 3 days, were evaluated retrospectively. Respiratory viral pathogens were detected using FTD Respiratory Pathogens 21 kit (Fast Tract Diagnos- tics, Siemens Healthineers Company). Two different kits based on real-time reverse transcription PCR were used for SARS-CoV-2 RNA detection in different periods. According to our results, at least one viral agent was detected in 2156 (24.4%) of a total of 8825 samples and a single agent was detected in 1843 (85.5%) of these. The distribution of viruses in the samples with a single agent was determined as RV, RSV A/B, HCoVs, AdV, flu A virus, MPV A/B, PIV 1-4, flu B virus, EV, BoV and PeV, in order of frequency. Multiple agents were found in 313 (14.5%) of these 2156 samples. They were found to be two agents in 291 samples, three in 21 samples and four in one sample. When the SARS-CoV-2 PCR test results of the patients who had positive results with respiratory tract multiplex PCR and who were studied within +/- 3 days were evaluated retrospectively, SARS-CoV-2 RNA was detected in 45 (3.5%) of 1277 samples in which at least one agent was detected. In four of these patients, SARS-CoV-2 was found together with multiple agents. Consequently, there was a sharp decrease in the prevalence of all viral agents during the pandemic period. It was evaluated that besides the COVID-19 infection, the restrictions applied during the pandemic period were also effective in this situation.
dc.identifier.doi10.5578/mb.20239952
dc.identifier.endpage659
dc.identifier.issn0374-9096
dc.identifier.issue4
dc.identifier.pmid37885392
dc.identifier.scopus2-s2.0-85175274696
dc.identifier.scopusqualityQ3
dc.identifier.startpage650
dc.identifier.trdizinid1206428
dc.identifier.urihttps://doi.org/10.5578/mb.20239952
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1206428
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4922
dc.identifier.volume57
dc.identifier.wosWOS:001116646200012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAnkara Microbiology Soc
dc.relation.ispartofMikrobiyoloji Bulteni
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectRespiratory tract viruses
dc.subjectCOVID-19
dc.subjectco-infection
dc.titleViral Respiratory Tract Infection Agents Detected Between Years 2019-2021, COVID-19, and Co-Infections
dc.title.alternative2019-2021 Yılları Arasında Saptanan Viral Solunum Yolu Enfeksiyonu Etkenleri, COVID-19 ve Ko-Enfeksiyonlar
dc.typeArticle

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