Repetitive Transcranial Magnetic Stimulation Improves Hippocampal N-Acetlaspartate Levels and Visual Memory Scores in Alzheimer's Disease

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dc.authorid0000-0002-3047-3613
dc.authorid0000-0002-2306-5937
dc.contributor.authorVelioglu, Halil Aziz
dc.contributor.authorSayman, Dila
dc.contributor.authorHanoglu, Lutfu
dc.contributor.authorAkan, Gulhan Ertan
dc.contributor.authorCankaya, Seyda
dc.contributor.authorYulug, Burak
dc.date.accessioned2026-01-24T12:29:26Z
dc.date.available2026-01-24T12:29:26Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractThe latest research into the pathophysiology of Alzheimer's Disease (AD) has included several cognitive deficits related to hippocampal functioning. However, current clinical research fails to consider the full extent of the heterogeneous cognitive spectrum of AD, resulting in a lack of the specific methods required to draw definitive diagnostic and therapeutic conclusions. This also includes in-vivo metabolic measurements for tailoring the diagnostic and therapeutic regimens in humans with AD. Magnetic resonance spectroscopy and repetitive transcranial magnetic stimulation (rTMS) are two novel diagnostic and therapeutic approaches that must be modified to treat AD. In the present study, we aimed to investigate the underlying therapeutic role of rTMS in humans with AD by evaluating the in -vivo hippocampal metabolites before and after rTMS treatment. Based on the data obtained using the fMRI data in our previous study and on the references reported in the literature, in the present study, we decided to use hippocampal NAA data after rTMS stimulation and found a significant increase in NAA levels. To the best of our knowledge, no other study has evaluated the effect of rTMS on hippocampal metabolites in humans with AD.
dc.identifier.doi10.29399/npa.28420
dc.identifier.endpage192
dc.identifier.issn1300-0667
dc.identifier.issn1309-4866
dc.identifier.issue2
dc.identifier.pmid38868852
dc.identifier.scopus2-s2.0-85196558005
dc.identifier.scopusqualityQ3
dc.identifier.startpage189
dc.identifier.trdizinid1282998
dc.identifier.urihttps://doi.org/10.29399/npa.28420
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1282998
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5337
dc.identifier.volume61
dc.identifier.wosWOS:001244741800016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi
dc.relation.ispartofNoropsikiyatri Arsivi-Archives of Neuropsychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectAD
dc.subjecthippocampus
dc.subjectMRS
dc.subjectNAA
dc.subjectrTMS
dc.titleRepetitive Transcranial Magnetic Stimulation Improves Hippocampal N-Acetlaspartate Levels and Visual Memory Scores in Alzheimer's Disease
dc.title.alternativeRepetitif Transkraniyal Manyetik Stimülasyon ile Alzheimer Hastalığında Hipokampal N-Asetilaspartat Düzeyinin ve Görsel Hafıza Skorlarının İyileştirilmesi
dc.typeArticle

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