Is calprotectin a reliable marker in surgical ICU settings? A clinical evaluation of its role in sepsis and mortality prediction

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dc.contributor.authorAladag, Ebru
dc.contributor.authorZora, Muhammed Emin
dc.contributor.authorGultekin, Yucel
dc.contributor.authorMizrak, Soycan
dc.date.accessioned2026-01-24T12:29:27Z
dc.date.available2026-01-24T12:29:27Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBackground: Calprotectin, a neutrophil-derived protein, has emerged as a potential biomarker for inflammation and infection. This study evaluated the utility of serum calprotectin levels in diagnosing sepsis and predicting mortality in surgical intensive care unit (ICU) patients. Methods: This prospective observational study included 124 patients admitted to the surgical ICU at U & scedil;ak Training and Research Hospital between 2022 and 2024. Data on demographics, serum calprotectin, CRP, PCT, lactate levels, and clinical scores (SOFA, APACHE II) were collected. ROC analysis was used for predictive accuracy; Spearman and Pearson correlation coefficients assessed associations. Results: No significant associations were found between serum calprotectin and SOFA/APACHE II scores, CRP, or lactate. However, calprotectin correlated positively with PCT in sepsis (r = 0.428, p = 0.002) negatively in postoperative subgroups (r = -0.48, p < 0.001). Calprotectin showed poor prognostic accuracy (AUC = 0.472). Mortality was significantly associated with high CRP and severity scores, but not with calprotectin levels. Conclusion: Calprotectin alone lacks sufficient diagnostic or prognostic power for sepsis in surgical ICU patients. It may serve as a complementary marker alongside PCT in specific subgroups.
dc.identifier.doi10.3389/fmed.2025.1619825
dc.identifier.issn2296-858X
dc.identifier.pmid41140665
dc.identifier.scopus2-s2.0-105019678173
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3389/fmed.2025.1619825
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5378
dc.identifier.volume12
dc.identifier.wosWOS:001600613900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers in Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectbiomarkers
dc.subjectcalprotectin
dc.subjectmortality prediction
dc.subjectsepsis
dc.subjectsurgical intensive care unit
dc.titleIs calprotectin a reliable marker in surgical ICU settings? A clinical evaluation of its role in sepsis and mortality prediction
dc.typeArticle

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