Is calprotectin a reliable marker in surgical ICU settings? A clinical evaluation of its role in sepsis and mortality prediction
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Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Frontiers Media Sa
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Calprotectin, a neutrophil-derived protein, has emerged as a potential biomarker for inflammation and infection. This study evaluated the utility of serum calprotectin levels in diagnosing sepsis and predicting mortality in surgical intensive care unit (ICU) patients. Methods: This prospective observational study included 124 patients admitted to the surgical ICU at U & scedil;ak Training and Research Hospital between 2022 and 2024. Data on demographics, serum calprotectin, CRP, PCT, lactate levels, and clinical scores (SOFA, APACHE II) were collected. ROC analysis was used for predictive accuracy; Spearman and Pearson correlation coefficients assessed associations. Results: No significant associations were found between serum calprotectin and SOFA/APACHE II scores, CRP, or lactate. However, calprotectin correlated positively with PCT in sepsis (r = 0.428, p = 0.002) negatively in postoperative subgroups (r = -0.48, p < 0.001). Calprotectin showed poor prognostic accuracy (AUC = 0.472). Mortality was significantly associated with high CRP and severity scores, but not with calprotectin levels. Conclusion: Calprotectin alone lacks sufficient diagnostic or prognostic power for sepsis in surgical ICU patients. It may serve as a complementary marker alongside PCT in specific subgroups.
Açıklama
Anahtar Kelimeler
biomarkers, calprotectin, mortality prediction, sepsis, surgical intensive care unit
Kaynak
Frontiers in Medicine
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
12
