Subjective cognitive decline in major depressive patients is associated with altered entropy and connectivity changes of temporal and insular region

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dc.authorid0009-0003-5293-3179
dc.authorid0000-0002-9704-6173
dc.authorid0009-0004-4955-0609
dc.contributor.authorYulug, Burak
dc.contributor.authorYalcinkaya, Ali
dc.contributor.authorSafa, Shair Shah
dc.contributor.authorSayman, Dila
dc.contributor.authorCankaya, Seyda
dc.contributor.authorKarakus, Ayse
dc.contributor.authorSayman, Ceyhun
dc.date.accessioned2026-01-24T12:31:21Z
dc.date.available2026-01-24T12:31:21Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractDepressive cognitive impairment is seen in a significant number of patients with depression. However, it remains challenging to differentiate between patients with amnestic (those with subjective cognitive impairment complaints) and non-amnestic major depressive disorder, highlighting the urgent need for additional objective tools to help classify these patients more accurately. We analyzed cognitive state, alterations in regional entropy and functional connectivity measures of the brain between patients with major depression and healthy controls. The depressed cohort was categorized as either amnestic or non-amnestic, depending on self-reported experiences of forgetfulness. The superior temporal region and insula exhibited altered entropy and connectivity measures in individuals with depression and subjective cognitive impairment, which was correlated with impaired executive functions, a pattern not being evident in the control group. Our findings support the notion that insular and superior temporal entropic alterations are linked to subjective cognitive changes in the pathology of depression. These regions also hold potential as biomarkers for determining the underlying objective cognitive deficits in subjective cognitive complaints in patients with major depressive disorder (MDD). This underscores the need for improved diagnostic approaches and the implementation of practical dynamic neuroimaging modalities capable of addressing the current challenges in diagnosing subjective cognitive impairment in MDD, offering promise for the future management of patients with depression.
dc.description.sponsorshipAdil Mardinoglu, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, UK; Royal Institute of Technology
dc.description.sponsorshipAdil Mardinoglu, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden. Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, UK. Open access funding provided by Royal Institute of Technology.
dc.identifier.doi10.1038/s41398-025-03518-w
dc.identifier.issn2158-3188
dc.identifier.issue1
dc.identifier.pmid40890120
dc.identifier.scopus2-s2.0-105014933894
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1038/s41398-025-03518-w
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5822
dc.identifier.volume15
dc.identifier.wosWOS:001564577400002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofTranslational Psychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectFunctional Connectivity
dc.subjectCortex
dc.subjectAnosognosia
dc.subjectImpairment
dc.subjectNetworks
dc.subjectDeficits
dc.subjectNoise
dc.titleSubjective cognitive decline in major depressive patients is associated with altered entropy and connectivity changes of temporal and insular region
dc.typeArticle

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