Dental Pulp-Derived Mesenchymal Stem Cells Increase Axon Numbers in Mental Nerve Repair

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dc.authorid0000-0003-2725-9330
dc.authorid0000-0003-0294-7559
dc.authorid0000-0002-4916-5071
dc.authorid0000-0002-8985-6918
dc.contributor.authorGonen, Zeynep Burcin
dc.contributor.authorColpak, Halis Ali
dc.contributor.authorYay, Arzu
dc.contributor.authorGokdemir, Nur Seda
dc.contributor.authorBahar, Dilek
dc.contributor.authorCanpolat, Dilek Gunay
dc.contributor.authorYalcin, Betul
dc.date.accessioned2026-01-24T12:31:01Z
dc.date.available2026-01-24T12:31:01Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractAimThe mental nerve, the extended part of the inferior alveolar nerve, is often injured during dentoalveolar, orthognathic, or tumor surgery. Numerous therapeutic interventions, including surgery and pharmacotherapy, have been used to enhance the recovery of nerve injuries. Dental pulp stem cells (DPSCs) represent an easily accessible source of adult stem cells that can be isolated from the pulp of extracted teeth. This study evaluated the effect of DPSCs on the regeneration of the mental nerve injury model of rabbits.MethodsIn this presented study, DPSCs were cultured and cell characterizations were performed by using flow cytometry and immunostainings. Bilateral mental nerve injury models of rabbits were created. In the control group (n = 10), saline was applied, and in the study group (n = 10), 2 x 106 DPSCs were applied to the repaired nerve areas. After 3 weeks, animals were killed and histological examination was obtained by using Masson's trichrome staining. An unpaired Student's t test was used when comparing the groups. Differences were considered to be statistically significant at P values of less than 0.05.ResultsThe DPSCs demonstrated a homogeneous population of mesenchymal stromal cells which expressed cluster of differentiation CD44, CD73, CD90, and CD105 and lack of CD34, CD45, and HLA-DR. Our finding clearly demonstrated that a lower number of cross-sectioned axons were founded in the control group (60.18 & PLUSMN; 2.52) compared to the study group (72.96 & PLUSMN; 2.43) (p = 0.00).ConclusionsDPSCs promote mental nerve axonal regeneration. These results suggest that DPSCs provide an important accessible source of adult stem cells for mental nerve regeneration.
dc.identifier.doi10.1007/s12663-023-01957-w
dc.identifier.endpage573
dc.identifier.issn0972-8279
dc.identifier.issn0974-942X
dc.identifier.issue3
dc.identifier.pmid38911401
dc.identifier.scopus2-s2.0-85163886809
dc.identifier.scopusqualityQ2
dc.identifier.startpage568
dc.identifier.urihttps://doi.org/10.1007/s12663-023-01957-w
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5597
dc.identifier.volume23
dc.identifier.wosWOS:001020537400001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer India
dc.relation.ispartofJournal of Maxillofacial & Oral Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectInferior alveolar nerve
dc.subjectMental nerve
dc.subjectPeripheral nerve regeneration
dc.subjectMesenchymal stem cells
dc.titleDental Pulp-Derived Mesenchymal Stem Cells Increase Axon Numbers in Mental Nerve Repair
dc.typeArticle

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