Evaluation of primary markers of inflammation and the systemic inflammation index in specific learning disabilities

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dc.authorid0000-0001-5938-3243
dc.authorid0000-0003-3046-2815
dc.authorid0000-0002-7637-1700
dc.authorid0000-0002-2156-3457
dc.contributor.authorAvsar, Pinar Aydogan
dc.contributor.authorKara, Tayfun
dc.contributor.authorKocaman, Orhan
dc.contributor.authorAkkus, Merve
dc.date.accessioned2026-01-24T12:31:29Z
dc.date.available2026-01-24T12:31:29Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractAim: Specific learning disorder (SLD) is a term that refers to reading, writing and arithmetic difficulties. The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and systemic inflammation index (SII) are affordable and accessible inflammatory biomarkers. This research aims to evaluate the relationship between NLR, PLR, SII and SLD to determine whether inflammation contributes to pathogenesis. Methods: This study included 90 SLD-diagnosed patients and 90 age-, sex- and ethnicity-matched healthy controls. Blood cell counts and NLR, PLR and SII values were obtained from medical records and compared between the two groups. Results: The NLR, PLR and SII were significantly higher (p = 0.029, p = 0.033 and p = 0.018 respectively) and lymphocyte counts were significantly lower (p = 0.041) in the SLD group. WISC-R total scores decreased with age in the SLD group (-1.988 coefficient, Beta = -0.247 beta, p = 0.041). Multivariate logistic regression analysis revealed that the SII was the only parameter independently associated with the diagnosis of SLD (Beta = 0.003, p = 0.023). Conclusion: Inflammation might play a role in SLD etiopathogenesis. NLR, PLR and SII may be potential biomarkers for SLD in children. Further research may lead to early diagnosis and additional anti-inflammatory pharmacological therapies for SLDs.
dc.description.sponsorshipThe authors have no acknowledgments to declare as the paper is entirely their own work.
dc.identifier.doi10.1080/17520363.2024.2404387
dc.identifier.endpage916
dc.identifier.issn1752-0363
dc.identifier.issn1752-0371
dc.identifier.issue20
dc.identifier.pmid39360657
dc.identifier.scopus2-s2.0-85205520465
dc.identifier.scopusqualityQ2
dc.identifier.startpage907
dc.identifier.urihttps://doi.org/10.1080/17520363.2024.2404387
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5921
dc.identifier.volume18
dc.identifier.wosWOS:001325564100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiomarkers in Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectinflammation biomarkers
dc.subjectneurodevelopmental disorders
dc.subjectNLR
dc.subjectPLR
dc.subjectSII
dc.subjectspecific learning disability
dc.titleEvaluation of primary markers of inflammation and the systemic inflammation index in specific learning disabilities
dc.typeArticle

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