Is age-related macular degeneration a local manifestation of systemic disorder? Changes in nailfold capillaries at age-related macular degeneration

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dc.contributor.authorKüçük, Mehmet Fatih
dc.contributor.authorAyan, Ayşe
dc.contributor.authorToslak, Devrim
dc.contributor.authorSüren, Elçin
dc.contributor.authorYaprak, Lütfiye
dc.contributor.authorÇetinkaya, Ersan
dc.contributor.authorÇoban, Deniz Turgut
dc.date.accessioned2021-02-19T21:16:09Z
dc.date.available2021-02-19T21:16:09Z
dc.date.issued2020
dc.departmentALKÜ
dc.descriptionAyan, Ayse/0000-0001-9488-2611; Kucuk, Mehmet Fatih/0000-0002-2548-7869; EROL, Muhammet Kazim/0000-0002-1720-8065
dc.description.abstractAims Determining whether nailfold capillary involvement is present in patients with Age-related macular degeneration (AMD) and whether there are different nailfold capillaroscopy findings between wet and dry types. Methods From January 2016 to December 2017, with an initial diagnosis of AMD, 53 consecutive adult patients (AMD group) and 91 age- and sex-matched healthy individuals were studied prospectively. There was no history of any other ocular disease and other disease affecting nailfold capillaries. All subjects underwent a complete ophthalmic examination. The classified and advanced stages of wet and dry types were not included. All nailfold capillaroscopy examinations were performed by the same rheumatologist. Results It was found that the frequency of major capillaroscopic findings such as capillary ectasia, micro-hemorrhage, tortuosity, neo-formation, bizarre capillary, and bushy capillaries increased in the AMD group according to the normal group, but no significant relationship was found for capillary aneurysm. In dry or wet type of AMD in terms of ectasia, micro-hemorrhage, tortuosity, neo-formation, bizarre structure, bushy structure, or aneurism of nailfold capillaries, no significant correlation was found. Conclusions Nailfold capillaroscopy can detect microvascular changes in the nailfold capillary, in early and late stages of AMD. There were morphological changes in the nailfold capillaries of AMD patients, suggesting that there are systemic superficial microvascular changes that may be due to the systemic nature of the disease.
dc.identifier.doi10.1007/s11845-019-02109-1
dc.identifier.endpage733en_US
dc.identifier.issn0021-1265
dc.identifier.issn1863-4362
dc.identifier.issue2en_US
dc.identifier.pmid31650451
dc.identifier.scopusqualityQ1
dc.identifier.startpage727en_US
dc.identifier.urihttps://doi.org/10.1007/s11845-019-02109-1
dc.identifier.urihttps://hdl.handle.net/20.500.12868/275
dc.identifier.volume189en_US
dc.identifier.wosWOS:000492324700003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherSpringer London Ltd
dc.relation.ispartofIrish Journal of Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAge-related macular degeneration
dc.subjectNailfold capillaroscopy
dc.subjectPathophysiology
dc.titleIs age-related macular degeneration a local manifestation of systemic disorder? Changes in nailfold capillaries at age-related macular degeneration
dc.typeArticle

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