The role of serum laboratory biomarkers for complicated and uncomplicated appendicitis in adolescents

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dc.contributor.authorŞengül, Serkan
dc.contributor.authorGüler, Yılmaz
dc.contributor.authorÇalış, Hasan
dc.contributor.authorKarabulut, Zülfikar
dc.date.accessioned2021-02-19T21:16:18Z
dc.date.available2021-02-19T21:16:18Z
dc.date.issued2020
dc.departmentALKÜ
dc.description.abstractObjective: To investigate if serum biomarkers could differentiate complicated and uncomplicated appendicitis in adolescents. Study Design: An cross sectional study. Place and Duration of Study: Department of General Surgery, Faculty of Medicine, Alanya Alaaddin Keykubat University, Alanya, Turkey, between January 2016 and December 2018. Methodology: Patients operated for acute appendicitis, aged between 10 and 19 years, were retrospectively evaluated. Patients were divided according to the negative appendectomy (group 1), uncomplicated appendicitis (group 2A) and complicated appendicitis (group 2B). White blood cell count (WBC), neutrophil count (NEU), lymphocyte count (LC), neutrophil/lymphocyte ratio (NLR), mean platelet volume (MPV), red cell distributions width (RDW), C-reactive protein (CRP), and length of hospital stay (LoHS) were analysed by ROC curve, one-way and Mann-Whitney U-tests. Results: There were 277 adolescents (group 1=30, group 2A=205 and group 2B=42). There were statistically significant differences between the groups in WBC, NEU, LYM, NLR, CRP, LoHS. The cut-off values of NLR, WBC, and NEU were 4.1, 10.6x10(9)/L, and 8.17x10(9)/L, respectively for uncomplicated appendicitis, and 7.32, 11.5x10(9)/L, and 10.3x10(9) /L, respectively for complicated appendicitis. The cut off value of CRP was 1.3 mg/dl for complicated appendicitis. Conclusions: Elevated WBC, NEU, CRP and NLR may be considered useful biomarkers in assisting physical examination and other diagnostic methods in distinguishing severity of acute appendicitis.
dc.identifier.doi10.29271/jcpsp.2020.4.420
dc.identifier.endpage424en_US
dc.identifier.issn1022-386X
dc.identifier.issn1681-7168
dc.identifier.issue4en_US
dc.identifier.pmid32513365
dc.identifier.scopusqualityQ2
dc.identifier.startpage420en_US
dc.identifier.urihttps://doi.org/10.29271/jcpsp.2020.4.420
dc.identifier.urihttps://hdl.handle.net/20.500.12868/371
dc.identifier.volume30en_US
dc.identifier.wosWOS:000538941700017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherColl Physicians & Surgeons Pakistan
dc.relation.ispartofJcpsp-Journal of the College of Physicians And Surgeons Pakistan
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdolescent
dc.subjectAppendicitis
dc.subjectNeutrophil-to-lymphocyte ratio
dc.subjectC-reactive protein
dc.subjectLength of hospital stay
dc.titleThe role of serum laboratory biomarkers for complicated and uncomplicated appendicitis in adolescents
dc.typeArticle

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