The Multifactorial Role of Pre-supplementary Motor Area Stimulation in the Freezing of Gait: An Alternative Strategy to the Classical Drug-Target Approach

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dc.contributor.authorSarıcaoğlu, Mevhibe
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorToprak, Güven
dc.contributor.authorHelvacı Yılmaz, Nesrin
dc.contributor.authorYuluğ, Burak
dc.date.accessioned2024-10-24T06:20:18Z
dc.date.available2024-10-24T06:20:18Z
dc.date.issued2022
dc.departmentALKÜ, Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractIntroduction: The pre-supplementary motor area (Pre-SMA) plays a pivotal role in the control of voluntary motor control and freezing of gait (FOG) pathophysiological mechanism. Here, we aimed to modulate if the pre-SMA would have beneficial effects on motor and behavioural outcomes in freezing of gait. To test this hypothesis, we examined the left pre-SMA stimulating effect of repetitive Transcranial Magnetic Stimulation (rTMS) on motor, cognitive and behavioural parameters in Parkinson's patients with FOG. Methods: The study included 20 Parkinson's patients with FOG (3 females, 17 males) who received the left Pre-SMA rTMS procedure. The clinical assessments were performed on all patients at the baseline and the patients were re-evaluated under the same clinical conditions one week after the end of the sessions. Results & discussion: We found significant improvements in motor, cognitive and behavioural symptoms (p<0.05). The main finding of our study is that Pre-SMA is an attractive stimulation area leading to critical improvement of symptoms of Parkinson's patients with FOG. Conclusion: The high-frequency rTMS stimulation over the left preSMA has a restorative effect on the motor, cognitive and behavioural symptoms of Parkinson's patients with FOG.
dc.identifier.doiDOI: 10.2174/1871530321666211014170107 Full text linksCite
dc.identifier.endpage524en_US
dc.identifier.issue5en_US
dc.identifier.startpage518en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/34649492/
dc.identifier.urihttps://hdl.handle.net/20.500.12868/2483
dc.identifier.volume22en_US
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofEndocr Metab Immune Disord Drug Targets
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFreezing of Gait
dc.subjectBehavioural Symptoms
dc.subjectCognitive Symptoms
dc.subjectMotor Symptoms
dc.subjectParkinson’s Disease
dc.subjectPresupplementary Area
dc.subjectRepetitive Transcranial Magnetic Stimulation
dc.titleThe Multifactorial Role of Pre-supplementary Motor Area Stimulation in the Freezing of Gait: An Alternative Strategy to the Classical Drug-Target Approach
dc.typeArticle

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