Effectiveness of autologous platelet-rich plasma for the healing of ulcers after endoscopic submucosal dissection

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dc.contributor.authorJeong, Eunju
dc.contributor.authorYoo, In Kyung
dc.contributor.authorÇakır, Özlem Özer
dc.contributor.authorKim, Hee Kyung
dc.contributor.authorKim, Won Hee
dc.contributor.authorHong, Sung Pyo
dc.contributor.authorCho, Joo Young
dc.date.accessioned2021-02-19T21:16:49Z
dc.date.available2021-02-19T21:16:49Z
dc.date.issued2019
dc.departmentALKÜ
dc.description.abstractBackground/Aims: Platelet-rich plasma (PRP) has been used for wound healing in various medical fields. The aim of this study was to evaluate the clinical efficacy and safety of local PRP injections after endoscopic submucosal dissection (ESD). Methods: Patients were non-randomly divided into the following two groups: (1) control group in which patients were administered only an intravenous proton pump inhibitor (PPI), and (2) a study group in which patients were administered an intravenous PPI and a topical PRP injection. We assessed the reduction in the ulcer area and stage of the ulcer after the procedure (24 hours, 48 hours, and 28 days after endoscopic surgery). Results: We enrolled 7 study and 7 control patients. In the study group, the rate of ulcer reduction was 59% compared to 52% in the control group (p=0.372), 28 days after ESD. There were 5 patients in the S stage and 2 patients in the H stage in the study group compared to no patient in the S stage and 7 patients in the H stage in the control group (p=0.05), 28 days after ESD. There were no serious complications in either group. Conclusions: The local injection of PRP is a safe and effective procedure for ulcer healing after ESD.
dc.identifier.doi10.5946/ce.2018.152
dc.identifier.endpage478en_US
dc.identifier.issn2234-2400
dc.identifier.issn2234-2443
dc.identifier.issue5en_US
dc.identifier.pmid31096727
dc.identifier.scopusqualityQ2
dc.identifier.startpage472en_US
dc.identifier.urihttps://doi.org/10.5946/ce.2018.152
dc.identifier.urihttps://hdl.handle.net/20.500.12868/562
dc.identifier.volume52en_US
dc.identifier.wosWOS:000496476800015
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherKorean Soc Gastrointestinal Endoscopy
dc.relation.ispartofClinical Endoscopy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEndoscopic submucosal dissection
dc.subjectPlatelet-rich plasma
dc.subjectUlcer healing
dc.titleEffectiveness of autologous platelet-rich plasma for the healing of ulcers after endoscopic submucosal dissection
dc.typeArticle

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