The Effect of Different Dental Implant Surface Characteristics on Bone Immunologic Biomarkers and Microbiologic Parameters: A Randomized Clinical Study

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dc.authorid0000-0003-0351-4894
dc.contributor.authorKarci, Bilge
dc.contributor.authorOncu, Elif
dc.contributor.authorDogan, Metin
dc.date.accessioned2026-01-24T12:29:04Z
dc.date.available2026-01-24T12:29:04Z
dc.date.issued2021
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractThis study assessed the levels of tumor necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2), receptor activator of nuclear factor kappa B (RANK), RANK ligand (RANKL), osteoprotegerin (OPG), and levels of Fusobacterium nucleatum, Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Prevotella intermedia, and Streptococcus oralis in areas where airborne particle-abraded, large-grit, acid-etched (SLA), fluorine-modified, and anodized implant surfaces are used. A total of 71 implants from 37 patients were assessed, grouped according to the surface characteristics of the implants: SLA surface (Group 1), fluorine-modified surface (Group 2), and anodized surface (Group 3). The following clinical indices were measured: Gingival Index (GI), probing depth (PD), bleeding on probing (BOP), clinical attachment level (CAL), and keratinized tissue width (KTW). Peri-implant sulcus fluid and subgingival plaque samples were also collected. Commercial enzyme-linked immunosorbent assay (ELISA) kits were purchased for measuring TNF-alpha, PGE2, RANKL, RANK, and OPG. Real-time quantitative polymerase chain reaction (PCR) was used to detect P intermedia, T forsythia, T denticola, F nucleatum, P gingivalis, and S oralis levels in the subgingival biofilms. The groups showed no statistically significant differences in GI, PD, BOP, CAL, KTW, or peri-implant status. The total amounts of PGE2, TNF-alpha, RANKL, RANK, and OPG and the RANKL/OPG ratio were not significantly different between groups. F nucleatum, T forsythia, P intermedia, P gingivalis, and T denticola were significantly higher in Group 3 implants. DNA concentrations of S oralis were higher in Group 2. Within the limitations of this study, SLA and fluorine-modified implant surfaces may be more clinically successful than anodized-surface implants.
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Projects Coordination Unit [161924001]
dc.description.sponsorshipThis study was supported by Necmettin Erbakan University Scientific Research Projects Coordination Unit with project no. 161924001. The authors declare no conflicts of interest.
dc.identifier.doi10.11607/prd.4448
dc.identifier.endpage+
dc.identifier.issn0198-7569
dc.identifier.issn1945-3388
dc.identifier.issue4
dc.identifier.pmid34328481
dc.identifier.scopus2-s2.0-85113275113
dc.identifier.scopusqualityQ1
dc.identifier.startpage589
dc.identifier.urihttps://doi.org/10.11607/prd.4448
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5115
dc.identifier.volume41
dc.identifier.wosWOS:000677684800019
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherQuintessence Publishing Co Inc
dc.relation.ispartofInternational Journal of Periodontics & Restorative Dentistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectGingival Crevicular Fluid
dc.subjectNecrosis-Factor-Alpha
dc.subjectResorption
dc.subjectKey
dc.titleThe Effect of Different Dental Implant Surface Characteristics on Bone Immunologic Biomarkers and Microbiologic Parameters: A Randomized Clinical Study
dc.typeArticle

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