Diclofenac sodium treatment ameliorates extrapancreatic organ injuries in a murine model of acute pancreatitis induced by caerulein

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dc.contributor.authorÇakır, Özlem Özer
dc.contributor.authorFındık, Sıddıka
dc.date.accessioned2021-02-19T21:16:17Z
dc.date.available2021-02-19T21:16:17Z
dc.date.issued2018
dc.departmentALKÜ
dc.descriptionFINDIK, SIDDIKA/0000-0002-3364-7498
dc.description.abstractAim. We determined the effects of diclofenac sodium, octreotide, and their combination on extrapancreatic organ injuries in caerulein-induced acute pancreatitis in mice. Methods. A total of 58 BALB-C male mice (25 g) were divided into seven groups and used to create a caerulein-induced acute pancreatitis model. Diclofenac sodium, octreotide, and their combination were given for treatment of caerulin-induced acute pancreatitis in mice. At the end of the experiment, the lung, liver, kidney, and stomach were removed for histopathologic assessment. Results. Histopathologic investigation revealed a statistically significant difference between the groups in mean congestion, edema, tubular injury, perirenal fat tissue inflammation, and tubular stasis scores in kidney tissue (P < 0 001, P < 0 001, P < 0 001, P < 0 001, and P = 0 048, respectively); mean congestion, edema, neutrophil inflammation, mononuclear inflammation, and emphysematous change scores in the lung (P < 0 001, P < 0 001, P < 0 001, P = 0 030, and P < 0 001, respectively); mean congestion, edema, and neutrophil inflammation scores in the stomach (P = 0 008, P = 0 014, and P < 0 001, respectively); and mean congestion and hydropic degeneration scores in the liver (P = 0 029 and P = 0 002, respectively). Conclusion. Diclofenac sodium alone ameliorates lung edema due to caerulin-induced acute pancreatitis.
dc.identifier.doi10.1155/2018/9829208
dc.identifier.issn1687-6121
dc.identifier.issn1687-630X
dc.identifier.pmid30515205
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1155/2018/9829208
dc.identifier.urihttps://hdl.handle.net/20.500.12868/359
dc.identifier.volume2018en_US
dc.identifier.wosWOS:000449871200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherHindawi Ltd
dc.relation.ispartofGastroenterology Research And Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleDiclofenac sodium treatment ameliorates extrapancreatic organ injuries in a murine model of acute pancreatitis induced by caerulein
dc.typeArticle

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