Paracetamol alters empathy scores in healthy and headache subjects: Functional MRI correlates

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dc.contributor.authorÇankaya, Şeyda
dc.contributor.authorÖktem, Ece Özdemir
dc.contributor.authorSaatçi, Özlem
dc.contributor.authorVehoğlu, Halil Aziz
dc.contributor.authorUygur, Abdullah Burak
dc.contributor.authorÖzşimşeka, Ahmet
dc.contributor.authorYuluğ, Burak
dc.date.accessioned2021-02-19T21:16:29Z
dc.date.available2021-02-19T21:16:29Z
dc.date.issued2020
dc.departmentALKÜ
dc.descriptionCankaya, Seyda/0000-0001-5309-0351
dc.description.abstractIntroduction: Although previous evidence suggest that paracetamol decreases psychological reactivity in healthy subjects, there is still no confirmed correlation between the empathy scores and brain activity in healthy and headache patients after paracetamol treatment. Material and methods: The study group included 16 patients with tension-type headache, and 12 healthy age-and sex-matched controls. After a detailed neurological examination Positive and Negative Affect Schedule (PANAS) and Empathy for Pain Scale (EPS) were applied to all subjects. Next, 1000 mg paracetamol tablet was administered orally, after administration of paracetamol, EPS were repeated, and fMRI was performed to all subjects. Results: We have revealed increased empathy scores in the headache group after the paracetamol treatment which were associated with significant alterations in brain regions which play a critical role in the processing of empathy. Discussion: The observed neuroimaging and clinical difference between healthy and headache subjects could be related to the fact that pain perception in healthy subjects might differ in some aspects from the mechanisms of empathy in headache-experienced patients. Conclusion: To the best of our knowledge, this is the first study that evaluated the paracetamol treatment and neural networks' correlation with pain empathy in healthy and headache individuals. (C) 2020 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.jocn.2020.04.053
dc.identifier.endpage221en_US
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.pmid32376158
dc.identifier.scopusqualityQ1
dc.identifier.startpage215en_US
dc.identifier.urihttps://doi.org/10.1016/j.jocn.2020.04.053
dc.identifier.urihttps://hdl.handle.net/20.500.12868/449
dc.identifier.volume78en_US
dc.identifier.wosWOS:000556833000037
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofJournal of Clinical Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectParacetamol
dc.subjectfMRI
dc.subjectPain Empathy
dc.titleParacetamol alters empathy scores in healthy and headache subjects: Functional MRI correlates
dc.typeArticle

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