Clinical Importance of P Wave Dispersion in Mitral Valve Prolapse

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dc.contributor.authorOncel, Can Ramazan
dc.contributor.authorKoseoglu, Cemal
dc.contributor.authorConer, Ali
dc.date.accessioned2026-01-24T12:29:12Z
dc.date.available2026-01-24T12:29:12Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjective: Mitral valve prolapse (MVP) is a widespread valvulopathy present in 2-6% of the population, affecting more than 170 million people globally. The objective of this study was to assess P wave dispersion (PWD) in patients with MVP to identify the presence of cardiovascular autonomic dysfunction and the potential risk of developing atrial arrhythmias in these patients. Materials and Methods: The study included 40 healthy control participants (Group 1), 41 patients with non-classic MVP (Group 2), and 36 patients with classic MVP (Group 3). Demographic and clinical characteristics were documented upon admission. An electrocardiographic assessment was conducted to quantify PWD values for both patients and the control group. Results: The minimum P wave duration was lower in classic MVP patients than in controls and non-classic MVP patients (63 +/- 3.6 vs. 70 +/- 2.0, p<0.001; 63 +/- 3.6 vs. 63 +/- 3.6, p<0.001, respectively). P wave dispersion was higher in classic MVP patients than in non-classic MVP patients (47.3 +/- 3.2 vs. 39.0 +/- 2.3, p=0.001). A significant positive correlation was detected between PWD and maximum P wave duration (Pmax), minimum P wave duration (Pmin), maximal leaflet displacement, maximal leaflet thickness, and left atrial diameter (LAD) (r=0.723, p<0.001; r=-0.771, p<0.001; r=0.557, p<0.001; r=0.770, p<0.001; r=0.517, p<0.001, respectively). Maximum leaflet thickness and maximum leaflet displacement were independent predictors of increased PWD in linear regression analysis (beta=1.456, p<0.001, beta=-0.851, p<0.001). Conclusion: Patients with classic MVP exhibited prolonged PWD values compared with non-classic MVP patients and normal controls.
dc.identifier.doi10.14744/cpr.2024.86184
dc.identifier.endpage547
dc.identifier.issn2980-2156
dc.identifier.issue6
dc.identifier.pmid41257174
dc.identifier.startpage542
dc.identifier.trdizinid1359822
dc.identifier.urihttps://doi.org/10.14744/cpr.2024.86184
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1359822
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5205
dc.identifier.volume46
dc.identifier.wosWOS:001362775800004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherErciyes Univ Sch Medicine
dc.relation.ispartofJournal of Clinical Practice and Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectAutonomic dysfunction
dc.subjectmitral valve prolapse
dc.subjectP wave dispersion
dc.titleClinical Importance of P Wave Dispersion in Mitral Valve Prolapse
dc.typeArticle

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