Histopathological and biochemical assessment of a novel diagnostic method for ovarian torsion

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dc.contributor.authorÖzekinci, Murat
dc.contributor.authorKüçüksayan, Ertan
dc.contributor.authorErdoğan, Gülgün
dc.contributor.authorAslan, Mutay
dc.contributor.authorPeştereli, Elif
dc.contributor.authorCanpolat, Murat
dc.contributor.authorSırcan Küçüksayan, Aslınur
dc.date.accessioned2021-02-19T21:16:26Z
dc.date.available2021-02-19T21:16:26Z
dc.date.issued2020
dc.departmentALKÜ
dc.descriptionKucuksayan, Ertan/0000-0002-1611-0875; Aslan, Mutay/0000-0002-0660-971X; Canpolat, Murat/0000-0003-3298-9725
dc.description.abstractOvarian torsion is agynecologic emergency that affects females of all ages. Early diagnosis is important to preserve ovarian function. The false positive rate for sonographic diagnosis of ovarian torsion is 50%; therefore, a new real-time approach is required to improve diagnostic accuracy. We investigated diffuse reflectance spectroscopy for diagnosing ovarian torsion. Spectroscopic measurements were performed in vivo prior to, during and after detorsion. After bilateral oophorectomy, hemoxygenase and myeloperoxidase enzyme activity in ovarian tissue was evaluated and the tissues were examined for pathology. Spectroscopic data were compared to histopathological and biochemical data to assess the diagnostic value of the spectroscopic method for differentiating healthy and damaged ovarian tissue. We found a good correlation between spectroscopy and histopathology. We also found a correlation between the spectroscopic data and heme oxygenase enzyme activity. We found no correlation between the histopathological tissue damage score and myeloperoxidase enzyme activity. Diffuse reflectance spectroscopy may be of prognostic and diagnostic value for ovarian torsion in vivo.
dc.identifier.doi10.1080/10520295.2019.1663558
dc.identifier.endpage209en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue3en_US
dc.identifier.pmid31570015
dc.identifier.scopusqualityQ2
dc.identifier.startpage203en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2019.1663558
dc.identifier.urihttps://hdl.handle.net/20.500.12868/431
dc.identifier.volume95en_US
dc.identifier.wosWOS:000489949200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHeme oxygenase
dc.subjectischemia
dc.subjectmyeloperoxidase
dc.subjectovary
dc.subjectspectroscopy
dc.subjecttissue damage
dc.subjecttorsion
dc.titleHistopathological and biochemical assessment of a novel diagnostic method for ovarian torsion
dc.typeArticle

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