Recent progress in chitosan-based nanoparticles for drug delivery: a review on modifications and therapeutic potential

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dc.contributor.authorBal, Kevser
dc.contributor.authorCelik, Sibel Kucukertugrul
dc.contributor.authorSenturk, Sema
dc.contributor.authorKaplan, Ozlem
dc.contributor.authorEker, Emine Busra
dc.contributor.authorGok, Mehmet Koray
dc.date.accessioned2026-01-24T12:31:27Z
dc.date.available2026-01-24T12:31:27Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractChitosan, obtained from chitin by deacetylation, is a versatile biopolymer known for its biocompatibility, biodegradability and environmental friendliness. Combined with its chemical and physical modifiability, these properties have made chitosan an important material in biomedical and pharmaceutical fields, especially in drug delivery systems. Chitosan-based nanomaterials exhibit enhanced functions through various chemical modifications such as thiolation, acetylation, carboxylation and phosphorylation, as well as through physical and enzymatic approaches. These modifications address inherent limitations such as poor solubility, limited acid resistance and insufficient mechanical strength, expanding the applications of chitosan in tissue engineering, gene therapy, vaccine delivery, wound healing and bioimaging. This review provides an in-depth analysis of the chemical structure, physicochemical properties and modification strategies of chitosan. It also explores current methodologies for preparing chitosan nanoparticles, along with drug loading and release techniques. Various targeting strategies employed in chitosan-based delivery systems are examined in detail. To illustrate the clinical relevance of these approaches, representative examples from recent therapeutic studies are included. Moreover, it highlights future research directions and the innovation potential of chitosan-based materials.
dc.identifier.doi10.1080/1061186X.2025.2502956
dc.identifier.endpage1393
dc.identifier.issn1061-186X
dc.identifier.issn1029-2330
dc.identifier.issue8
dc.identifier.pmid40336193
dc.identifier.scopus2-s2.0-105005489582
dc.identifier.scopusqualityQ1
dc.identifier.startpage1366
dc.identifier.urihttps://doi.org/10.1080/1061186X.2025.2502956
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5888
dc.identifier.volume33
dc.identifier.wosWOS:001488041700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Drug Targeting
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectChitosan
dc.subjectchemical modifications
dc.subjectdrug delivery
dc.subjecttargeted delivery
dc.subjectchitosan nanoparticles
dc.titleRecent progress in chitosan-based nanoparticles for drug delivery: a review on modifications and therapeutic potential
dc.typeReview Article

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