Determination of the Cytotoxicity and Antibiofilm Potential Effect of Equisetum arvense Silver Nanoparticles

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dc.authorid0000-0001-6829-1279
dc.contributor.authorAkar, Zeynep
dc.contributor.authorAkay, Seref
dc.contributor.authorEjder, Nebahat
dc.contributor.authorDuzgun, Azer Ozad
dc.date.accessioned2026-01-24T12:30:59Z
dc.date.available2026-01-24T12:30:59Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractThis study aimed to synthesize and characterize silver nanoparticles (AgNPs) by green synthesis from Equisetum arvense (Ea) extracts and to investigate their cytotoxicity, antibiofilm activity, and alpha-glucosidase enzyme inhibition. Diverse characterization techniques were applied to verify the production of nanoparticles. SEM examination confirmed that the size of nanoparticles is in the range of 40-60 nm. Also, interactions between silver and natural compounds of plant extract were confirmed through FT-IR and EDX analyses. It was determined that Equisetum arvense silver nanoparticles had antibiofilm activity against three different clinical strains with high biofilm-forming ability. AgNPs reduced the biofilm-forming capacity of clinical A. baumannii isolate with strong biofilm-forming capacity by approximately twofold, while the capacity of clinical K.pneumonaie and E.coli isolates decreased by 1.5 and 1.2 fold, respectively. The alpha-glucosidase enzyme inhibition potential of the AgNPs, which is determined as 93.50%, was higher than the plant extract with, and the alpha- 30.37%. MTT was performed to assess whether incubation of nanoparticles with A549 and ARPE-19 cell lines affected their viability, and a dramatic reduction in cell growth inhibition of both A549 and ARPE-19 cells was observed. It has been shown that A549 cells treated with 200 and 150 mu g/mL nanoparticles had less cell proliferation compared to control cells at 24-h and 48-h incubation time. According to these results, Ea-derived AgNPs appear to have potential anticancer activity against A549 cancer cells. Investigating the effects of green synthesis nanoparticles on microbial biofilm and various tumors may be important for developing new therapies. The outcomes of this study have showed that Ea-AgNPsmay have a high potential both in the treatment of pathogenic strains that form biofilms, as well as in anticancer therapy use.
dc.identifier.doi10.1007/s12010-023-04587-7
dc.identifier.endpage922
dc.identifier.issn0273-2289
dc.identifier.issn1559-0291
dc.identifier.issue2
dc.identifier.pmid37273097
dc.identifier.scopus2-s2.0-85160960970
dc.identifier.scopusqualityQ2
dc.identifier.startpage909
dc.identifier.urihttps://doi.org/10.1007/s12010-023-04587-7
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5571
dc.identifier.volume196
dc.identifier.wosWOS:001000891200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofApplied Biochemistry and Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectAntibiofilm
dc.subjectAnticancer
dc.subjectGreen synthesis
dc.subjectNanotechnology
dc.subjectSilver nanoparticle
dc.titleDetermination of the Cytotoxicity and Antibiofilm Potential Effect of Equisetum arvense Silver Nanoparticles
dc.typeArticle

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