Design and fabrication of low-cost microsystems for production of chitosan particles

Basit Öğe Kaydı
dc.authorid0000-0001-6829-1279
dc.contributor.authorAkay, Seref
dc.contributor.authorOzdilek, Hasret
dc.date.accessioned2026-01-24T12:29:18Z
dc.date.available2026-01-24T12:29:18Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractRecent research has focused on the methods for administration of medications in a controlled manner while minimizing side effects. Cross -linked hydrogels have wide application area as nanocarriers. There are many approaches for developing suitable methods to produce ideal particles. Advances in microtechnology have been considered as a solution to produce controlled drug delivery systems, however, it is limited due to the necessity for specialized laboratories. In this study, a simple method to produce antibiotic -loaded chitosan particles is proposed. Production was carried out with two different designs, a syringe -based flow focusing system (outer diameter of 1 mm, inner diameter of 120 mu m) and microchannel with 250 mu m width and 100 mu m height fabricated with the computer numerical control (CNC). Sodium Triphosphate (TPP) was used as cross -linking agent for the production of particles and the effects of the concentration and flow rates on the particle formation was investigated. It has been observed that particles can be produced in a syringe -based system, but the resulting particles are not homogeneous. In the studies carried out with CNC microchannel, it was determined by SEM analysis that the obtained particles ranged in size from 39 to 771 nm, and it was seen that the CNC microchannel was more effective at low and equal flow rates (25 mu l/min). It has been found that increasing the flow rate and concentration of chitosan increases the particle size. It was determined that Ampicillin loaded particles synthesized with the CNC microchannel exhibited high inhibition against Gram positive and Gram negative bacteria. These results show that the proposed approaches for the design of microsystems can be used in the formation of drug carriers without the need for specialized laboratories and expertise.
dc.description.sponsorshipGmscedil;hane University, Scientific Research Projects Coordination Department [F5119.0101]
dc.description.sponsorshipThis study has been supported by Guemue & scedil;hane University, Scientific Research Projects Coordination Department. Project Number: 19.F5119.0101.
dc.identifier.doi10.17341/gazimmfd.1299367
dc.identifier.endpage2372
dc.identifier.issn1300-1884
dc.identifier.issn1304-4915
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85195678431
dc.identifier.scopusqualityQ2
dc.identifier.startpage2363
dc.identifier.trdizinid1257598
dc.identifier.urihttps://doi.org/10.17341/gazimmfd.1299367
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1257598
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5258
dc.identifier.volume39
dc.identifier.wosWOS:001265086400003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherGazi Univ, Fac Engineering Architecture
dc.relation.ispartofJournal of The Faculty of Engineering and Architecture of Gazi University
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectAntimicrobial
dc.subjectchitosan
dc.subjectdrug delivery
dc.subjectmicrofluidic
dc.subjectmicrofabrication
dc.titleDesign and fabrication of low-cost microsystems for production of chitosan particles
dc.title.alternativeKitosan parçacıklarının üretimi için düşük maliyetli mikrosistemlerin tasarımı ve fabrikasyonu
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu