Expressions of Notch signalling pathway members during early pregnancy in mice

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dc.authorid0000-0002-1177-2351
dc.authorid0000-0002-2860-5592
dc.authorid0000-0003-2531-0788
dc.contributor.authorAcar, Nuray
dc.contributor.authorSoylu, Hakan
dc.contributor.authorAvci, Sema
dc.contributor.authorUstunel, Ismail
dc.date.accessioned2026-01-24T12:30:58Z
dc.date.available2026-01-24T12:30:58Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractAlthough pregnancy is initiated and maintained through highly complex mechanisms, it is essential to understand the events that occur before and during early pregnancy to understand a healthy implantation process. The Notch signal, thought to be involved in this process, is frequently the subject of research with its different aspects. To better understand the role of Notch signaling in the peri-implantation period of the mouse uterus, we investigated the state of expression and localization of Notch 3, Notch 4, Rbp-J, Hes1, Hes7, Hey2, HeyL, and Fbw7 in the uterus and implantation sites in early pregnancy. Balb/C mice were divided into groups D1, D4, D5, D6, and D8. For D5 and D6 groups, implantation sites were identified by intravenous injection of Chicago blue. IHC, WB, and QRT-PCR methods were used. Notch 3 was very strong positive on the 4th day of pregnancy. Notch 4 was highly expressed on days 4, 5, 6, and 8 of pregnancy when P-4 levels were high. Hes 1 level was at the lowest on the 4th day of pregnancy. Hes 7 protein expression gradually increased from D1 to D8 in the uteri and implantation sites. Hey 2 expression was at the highest level on the 1st and 4th days. Hey L expression was on the apical of the glands. Fbxw7 that expression was high on the 1st and 4th days of pregnancy. Notch signaling may play an essential role in regulating endometrial receptivity. In addition, our Hes7 results are new to the literature.
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu [213S032] Funding Source: Medline
dc.identifier.doi10.1007/s10735-023-10132-x
dc.identifier.endpage312
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue4
dc.identifier.pmid37344690
dc.identifier.scopus2-s2.0-85162272709
dc.identifier.scopusqualityQ2
dc.identifier.startpage297
dc.identifier.urihttps://doi.org/10.1007/s10735-023-10132-x
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5539
dc.identifier.volume54
dc.identifier.wosWOS:001013812800002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Molecular Histology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectMouse
dc.subjectPregnancy
dc.subjectUterus
dc.subjectDecidua
dc.subjectNotch signaling
dc.titleExpressions of Notch signalling pathway members during early pregnancy in mice
dc.typeArticle

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