Decreased IL-33 Expression in the Cervix in LPS-Induced Preterm Birth and the Potential Role of Mast Cells: A Murine Model

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dc.authorid0000-0003-0370-8680
dc.contributor.authorAvci, Sema
dc.contributor.authorCelik-Ozenci, Ciler
dc.contributor.authorKuscu, Nilay
dc.contributor.authorBektas, Nayce Ilayda
dc.date.accessioned2026-01-24T12:29:01Z
dc.date.available2026-01-24T12:29:01Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractProblem: In order to gain a deeper understanding of the mechanisms underlying LPS-mediated preterm birth, it is crucial to investigate the relationship between preterm birth and mast cells (MCs). Moreover, the role of antihistamines in inflammatory processes during pregnancy remains incompletely understood. Method of Study: CD-1 female mice were administered intrauterine lipopolysaccharide (LPS) via midline laparotomy to establish an inflammation-induced preterm birth model. The experimental groups (n = 6 per group) were formed as Nonpregnant and pregnant control, Sham, PBS, LPS, Cetirizine (CET) control, and two CET treatment groups (CET 10 mg/kg-low dose, and CET 20 mg/kg-high dose with LPS administration). Tissue samples were analyzed using immunohistochemistry and Western blot techniques. Results: Our findings suggest that MCs play a significant role in preterm birth, with LPS administration inducing MC dysfunction in the reproductive tract during pregnancy. Additionally, high doses of CET may support inflammatory responses. A particularly notable result was the reduction in interleukin-33 (IL-33) expression in the cervix during LPS-induced preterm birth. This suggests that IL-33 may serve as a potential biomarker for preterm birth in the cervix. Conclusions: The effects of CET during LPS-mediated preterm birth appear to be dose-dependent, warranting further exploration of their role in this context.
dc.description.sponsorshipScientific and Technological Research Council of Turkey [121S341]; Scientific and Technological Research Council of Turkey (TUBITAK)
dc.description.sponsorshipWe want to thank student Cemre Nur Balc & imath; for her assistance. This research was supported by the Scientific and Technological Research Council of Turkey (TUBITAK, Project number 121S341, S.A.).
dc.identifier.doi10.1111/aji.70085
dc.identifier.issn1046-7408
dc.identifier.issn1600-0897
dc.identifier.issue5
dc.identifier.pmid40328686
dc.identifier.scopus2-s2.0-105004477563
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/aji.70085
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5080
dc.identifier.volume93
dc.identifier.wosWOS:001482648000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAmerican Journal of Reproductive Immunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectcetirizine
dc.subjectIL-33
dc.subjectinflammation
dc.subjectmast cell
dc.subjectpreterm birth
dc.titleDecreased IL-33 Expression in the Cervix in LPS-Induced Preterm Birth and the Potential Role of Mast Cells: A Murine Model
dc.typeArticle

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