The Role of Willpower in Major Depressive Disorder: An fMRI Study

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dc.contributor.authorYulug, Burak
dc.contributor.authorUygur, Burak
dc.contributor.authorSayman, Dila
dc.contributor.authorCankaya, Seyda
dc.contributor.authorAyyildiz, Behcet
dc.contributor.authorAyyildiz, Sevilay
dc.contributor.authorOktem, Ece Ozdemir
dc.date.accessioned2026-01-24T12:30:49Z
dc.date.available2026-01-24T12:30:49Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractIntroduction The brain network correlates of personality traits in major depressive disorder (MDD) have not yet been investigated. Furthermore, it is still unclear whether personality traits relate to the depressive episode.Methods This study assessed network properties, depression severity, and personality traits in patients with MDD (n = 25) compared with age- and sex-matched healthy controls (n = 22). We performed TCI questionnaire which assesses novelty seeking (NS, an urge to explore new experiences with heightened emotional responses), harm avoidance (HA, the tendency to hold back when faced with unpleasant situations), reward dependence (RD, a tendency to seek and value rewards rooted in social recognition), persistence (P, an individual's ability to remain focused and driven toward goals despite encountering challenges), self-directness (SD, an expression of willpower that enables individuals to adapt their behavior to situational demands while remaining focused on their personal goals and values), cooperativeness (C, a behavioral trait reflecting a person's general approach to others; ranging from friendly and cooperative to hostile), and self-transcendence (ST, lessening of self-centeredness, allowing for expanded empathy) traits of participants.Results MDD patients with distinctive character traits exhibited significant differences in terms of depression diagnosis and severity of Hamilton Depression Rating Scale scores compared to the controls. The MDD patients also exhibited reduced resting-state network activity between the posterior default mode network, right putamen, and right frontal pole, while SD was significantly less frequently diagnosed in MDD patients. In evaluating the network correlates, differences in the SD traits were significantly associated with critical brain network alterations that were not evident in other traits.Discussion To the best of our knowledge, this is the first study to provide preliminary evidence of an abnormal connectome in the SD trait in MDD, thus providing convincing evidence for personalized antidepressant treatment strategies in MDD. A small sample size and our depression group being not drug-naive were our limitation for this research.
dc.description.sponsorshipAdil Mardinoglu
dc.description.sponsorshipThis study was supported by the Adil Mardinoglu.
dc.identifier.doi10.1002/brb3.70921
dc.identifier.issn2162-3279
dc.identifier.issue10
dc.identifier.pmid41116659
dc.identifier.scopus2-s2.0-105019334022
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/brb3.70921
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5444
dc.identifier.volume15
dc.identifier.wosWOS:001597908700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofBrain and Behavior
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectdepression
dc.subjectdorsal DMN
dc.subjectfMRI
dc.subjectfrontal pole
dc.subjectputamen
dc.subjectself-directness
dc.titleThe Role of Willpower in Major Depressive Disorder: An fMRI Study
dc.typeArticle

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