The Adaptive Role of Entorhinal Cortical Thickness in Post-COVID 19 Cognitive Impairment

Basit Öğe Kaydı
dc.contributor.authorCankaya, Seyda
dc.contributor.authorIpek, Lutfiye
dc.contributor.authorAyyildiz, Sevilay
dc.contributor.authorSayman, Dila
dc.contributor.authorKaraca, Ramazan
dc.contributor.authorAyyildiz, Behcet
dc.contributor.authorVelioglu, Halil Aziz
dc.date.accessioned2026-01-24T12:29:26Z
dc.date.available2026-01-24T12:29:26Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractIntroduction: Only limited information is still available concerning cognitive dysfunctions and cortical thickness in individuals who recovered from mild COVID-19 infections and did not require hospitalization. Our aim was to evaluate if the highly adaptive potential of cortical thickness might play a critical role in COVID-19-related cognitive disorder in a compensatory manner. Methods: Fifteen individuals with no history of medical, neurological, or psychiatric disease and with positive COVID-19 test results, and sixteen healthy age and education-matched healthy controls identified from the official hospital health system were evaluated in terms of cognitive scores using Alzheimer Disease's Assessment Scale-cognitive subscale (ADAS-Cog) and brain MRI cortical thickness measurements using FreeSurfer Version 7.40. Results: An increased cortical thickness in the right entorhinal cortex (EC) and impaired cognition (increased ADAS score) were observed in the post-COVID 19 group as compared to the controls confirmed by the student's t test (respectively, p-0.006, p<0.001). The apparent correlation observed between cognitive impairment and increased entorhinal cortical thickness in our COVID-19 patients might suggest a continuum pathophysiology between healthy and COVID-19 affected brains that was not evident in previous COVID-19 cases with cognitive impairment. Conclusion: Our findings of increased entorhinal cortical thickness, together with impaired cognitive scores, may indicate a flexible role of EC thickness in compensatory mechanisms of cognition.
dc.description.sponsorshipIstanbul Medipol University Research Institute for Health and Technologies (SABITA)
dc.description.sponsorshipThe authors of this work are greatly indebted to the Istanbul Medipol University Research Institute for Health and Technologies (SABITA) .
dc.identifier.doi10.29399/npa.28813
dc.identifier.endpage314
dc.identifier.issn1300-0667
dc.identifier.issn1309-4866
dc.identifier.issue4
dc.identifier.pmid41383898
dc.identifier.scopus2-s2.0-105025713690
dc.identifier.scopusqualityQ3
dc.identifier.startpage310
dc.identifier.urihttps://doi.org/10.29399/npa.28813
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5338
dc.identifier.volume62
dc.identifier.wosWOS:001634892200004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi
dc.relation.ispartofNoropsikiyatri Arsivi-Archives of Neuropsychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectcognitive impairment
dc.subjectentorhinal cortical thickness
dc.subjectpost-COVID-19
dc.subjectcognitive impairment
dc.subjectentorhinal cortical thickness
dc.subjectpost-COVID-19
dc.titleThe Adaptive Role of Entorhinal Cortical Thickness in Post-COVID 19 Cognitive Impairment
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu