Gut barrier protein levels in serial blood samples from critically ill trauma patients during and after intensive care unit stay

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dc.authorid0000-0002-2766-4312
dc.authorid0000-0001-8429-009X
dc.authorid0000-0001-6473-5813
dc.authorid0000-0002-7925-8121
dc.authorid0000-0002-3555-3946
dc.authorid0000-0003-4496-9473
dc.authorid0000-0002-8260-9295
dc.contributor.authorDonmez-Altuntas, Hamiyet
dc.contributor.authorErgul, Serap Sahin
dc.contributor.authorAltin-Celik, Pinar
dc.contributor.authorBulut, Kadir
dc.contributor.authorEciroglu, Hamiyet
dc.contributor.authorUzen, Ramazan
dc.contributor.authorSahin, Gulsah Gunes
dc.date.accessioned2026-01-24T12:30:51Z
dc.date.available2026-01-24T12:30:51Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractPurposeIn an effort to better manage critically ill patients hospitalised in the intensive care unit (ICU) after experiencing multiple traumas, the present study aimed to assess whether plasma levels of intestinal epithelial cell barrier proteins, including occludin, claudin-1, junctional adhesion molecule (JAM-1), tricellulin and zonulin, could be used as novel biomarkers. Additional potential markers such as intestinal fatty acid-binding protein (I-FABP), d-lactate, lipopolysaccharide (LPS) and citrulline were also evaluated. We also aimed to determine the possible relationships between the clinical, laboratory, and nutritional status of patients and the measured marker levels.MethodsPlasma samples from 29 patients (first, second, fifth and tenth days in the ICU and on days 7, 30 and 60 after hospital discharge) and 23 controls were subjected to commercial enzyme-linked immunosorbent assay (ELISA) testing.ResultsOn first day (admission) and on the second day, plasma I-FABP, d-lactate, citrulline, occludin, claudin-1, tricellulin and zonulin levels were high in trauma patients and positively correlated with lactate, C-reactive protein (CRP), number of days of ICU hospitalisation, Acute Physiology and Chronic Health Evaluation II (APACHE II) score and daily Sequential Organ Failure Assessment (SOFA) scores (P < 0.05-P < 0.01).ConclusionThe results of the present study showed that occludin, claudin-1, tricellulin and zonulin proteins, as well as I-FABP, d-lactate and citrulline, may be used as promising biomarkers for the evaluation of disease severity in critically ill trauma patients, despite the complexity of the analysis of various barrier markers. However, our results should be supported by future studies.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Erciyes University [8633]
dc.description.sponsorshipThis work was funded by the Scientific Research Projects Coordination Unit of Erciyes University (Project ID: 8633).
dc.identifier.doi10.1007/s00068-023-02298-6
dc.identifier.endpage2213
dc.identifier.issn1863-9933
dc.identifier.issn1863-9941
dc.identifier.issue5
dc.identifier.pmid37296330
dc.identifier.scopus2-s2.0-85161446843
dc.identifier.scopusqualityQ1
dc.identifier.startpage2203
dc.identifier.urihttps://doi.org/10.1007/s00068-023-02298-6
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5493
dc.identifier.volume49
dc.identifier.wosWOS:001003911700002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofEuropean Journal of Trauma and Emergency Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectCitrulline
dc.subjectClaudin-1
dc.subjectd-lactate
dc.subjectIntensive care
dc.subjectI-FABP
dc.subjectJAM-1
dc.subjectLPS
dc.subjectOccludin
dc.subjectTricellulin
dc.subjectZonulin
dc.titleGut barrier protein levels in serial blood samples from critically ill trauma patients during and after intensive care unit stay
dc.typeArticle

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