Evaluation of biocomposite putty with strontium and zinc co-doped 45S5 bioactive glass and sodium hyaluronate

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dc.authorid0000-0001-9015-3104
dc.authorid0000-0002-4864-0598
dc.authorid0000-0002-6288-2091
dc.contributor.authorOzel, Cem
dc.contributor.authorCevlik, Cem Batuhan
dc.contributor.authorOzarslan, Ali Can
dc.contributor.authorEmir, Ceren
dc.contributor.authorElalmis, Yeliz Basaran
dc.contributor.authorYucel, Sevil
dc.date.accessioned2026-01-24T12:31:10Z
dc.date.available2026-01-24T12:31:10Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractThe application of powder or granule formed bioactive glasses in the defect area with the help of a liquid carrier to fill the defects is a subject of interest and is still open to development. In this study, it was aimed to prepare biocomposites of bioactive glasses incorporating different co-dopants with a carrier biopolymer and to create a fluidic material (Sr and Zn co-doped 45S5 bioactive glassessodium hyaluronate). All biocomposite samples were pseudoplastic fluid type, which may be suitable for defect filling and had excellent bioactivity behaviors confirmed by FTIR, SEM-EDS and XRD. Biocomposites with Sr and Zn co-doped bioactive glass had higher bioactivity considering the crystallinity of hydroxyapatite formations compared to biocomposite with undoped bioactive glasses. Biocomposites with high bioactive glass content had hydroxyapatite formations with higher crystallinity compared to biocomposites with low bioactive glass. Furthermore, all biocomposite samples showed non-cytotoxic effect on the L929 cells up to a certain concentration. However, biocomposites with undoped bioactive glass showed cytotoxic effects at lower concentrations compared to biocomposites with co-doped bioactive glass. Thus, biocomposite putties utilizing Sr and Zn co-doped bioactive glasses may be advantageous for orthopedic applications due to their specified rheological, bioactivity, and biocompatibility properties.
dc.description.sponsorshipYildiz Technical University Scientific Research Projects Coordination Unit [FLY-2019-3618]; TUBITAK [BIDEB/2210-C]; [BIDEB/2211-A]
dc.description.sponsorshipThe authors would like to acknowledge that this paper is submitted in partial fulfillment of the requirements for PhD degree at Yildiz Technical University. This work has been supported by Yildiz Technical University Scientific Research Projects Coordination Unit under project number FLY-2019-3618. Cem OZEL also thanks the financial support from the TUBITAK under the BIDEB/2211-A National PhD Scholarship Program. Cem Batuhan Cevlik also thanks the financial support from the TUBITAK under the BIDEB/2210-C National MSc/MA Scholarship Program in the Priority Fields in Science and Technology. Authors also wish to acknowledge Meta Bioengineering and R & D Services Inc. for their support in 45S5 bioactive glass production via MDD regulations (Medical Devices Directive; 93/42/EEC Annex-II section 3 and 4) and ISO standardizations (Medical Devices-Quality Management Systems Requirements for Regulatory Purposes; ISO 13485:2016).
dc.identifier.doi10.1016/j.ijbiomac.2023.124901
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid37210057
dc.identifier.scopus2-s2.0-85159768120
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2023.124901
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5706
dc.identifier.volume242
dc.identifier.wosWOS:001013059500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectBioactive glass
dc.subjectBioactivity
dc.subjectBiocomposite
dc.subjectPutty
dc.subjectCo -doped
dc.subjectStrontium and zinc
dc.titleEvaluation of biocomposite putty with strontium and zinc co-doped 45S5 bioactive glass and sodium hyaluronate
dc.typeArticle

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