Synthesis of Resveratrol Loaded Hybrid Silica-PAMAM Dendrimer Nanoparticles With Emphases on Inducible Nitric Oxide Synthase and Cytotoxicity

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dc.authorid0000-0001-9015-3104
dc.authorid0000-0003-4509-2212
dc.authorid0000-0003-1880-4261
dc.contributor.authorKececiler-Emir, Ceren
dc.contributor.authorIlhan-Ayisigi, Esra
dc.contributor.authorCelen-Erden, Cigdem
dc.contributor.authorNalbantsoy, Ayse
dc.contributor.authorYesil-Celiktas, Ozlem
dc.date.accessioned2026-01-24T12:30:59Z
dc.date.available2026-01-24T12:30:59Z
dc.date.issued2021
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractResveratrol is a naturally occurring polyphenolic compound exhibiting therapeutic activities. However, the stability can be altered by UV light, pH and changes in temperature. Encapsulation would be an ideal strategy to improve the stability and bioavailability. Thus, trans-resveratrol (Res) was encapsulated within hybrid nanoparticles consisted with silica and G4 polyamidoamine dendrimer (PAMAM) by sol-gel method. The diameters of synthesized nanoparticles (NPs) were at a range of 212-574 nm and the encapsulation efficiency was 86 %. RAW 264.7 murine macrophage cell line induced with endotoxin/lipopolysaccharide was treated with free resveratrol and Res-loaded NPs for assessing inhibition of inducible nitric oxide synthase (iNOS), where IC50 values of free resveratrol and Res-loaded NPs were 122.68 mu M and 249.74 mu M. As for cytotoxicity, IC50 values of free resveratrol were found as 176.57 mu M and 201.54 mu M for MCF-7 and MDA-MB-231 cells, whereas 197.16 mu M and 219.07 mu M for Res-loaded NPs for the respective cell lines. Overall, sol-gel technique proved to be an ideal technology as can be carried out under mild conditions and Res-loaded NPs have potential to be utilized in the industry.
dc.description.sponsorshipTUBITAK 2209-A [1919B011400901]
dc.description.sponsorshipThis work was supported byy TUBITAK 2209-A research project grant (1919B011400901).
dc.identifier.doi10.1007/s11130-021-00897-5
dc.identifier.endpage225
dc.identifier.issn0921-9668
dc.identifier.issn1573-9104
dc.identifier.issue2
dc.identifier.pmid33950366
dc.identifier.scopus2-s2.0-85105499850
dc.identifier.scopusqualityQ1
dc.identifier.startpage219
dc.identifier.urihttps://doi.org/10.1007/s11130-021-00897-5
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5555
dc.identifier.volume76
dc.identifier.wosWOS:000647338000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPlant Foods For Human Nutrition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectSol? gel
dc.subjectNanoparticle
dc.subjectPAMAM
dc.subjectResveratrol
dc.subjectCytotoxicity
dc.subjectiNOS
dc.titleSynthesis of Resveratrol Loaded Hybrid Silica-PAMAM Dendrimer Nanoparticles With Emphases on Inducible Nitric Oxide Synthase and Cytotoxicity
dc.typeArticle

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