Targeting the parietal memory network with tDCS in MCI: study protocol for a randomized controlled trial

Basit Öğe Kaydı
dc.contributor.authorCankaya, Seyda
dc.contributor.authorAkturk, Aynur
dc.contributor.authorKarakus, Ayse
dc.contributor.authorHanoglu, Lutfu
dc.contributor.authorMardinoglu, Adil
dc.contributor.authorYulug, Burak
dc.date.accessioned2026-01-24T12:29:28Z
dc.date.available2026-01-24T12:29:28Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBackground: Mild cognitive impairment (MCI) is a critical transitional stage in dementia related disorders. In that context, dorsolateral prefrontal cortex (DLPFC), and lateral parietal cortex (LPC) are subjected to neuropathological changes in MCI. Furthermore, alterations in parietal memory network (PMN) integrity and default mode network (DMN) also occur in MCI. Transcranial direct current stimulation (tDCS) is a promising neuroprotective tool that might interfere with cognitive decline in Alzheimer's disease-MCI (aMCI) and Parkinson's disease-MCI (PD-MCI) when applied to DLPFC or LPC separately. Methods: This is a randomized and controlled study evaluating the effectiveness of tDCS in 120 patients (60 aMCI and 60 PD-MCI). Firstly, all patients will be randomly (1:1) divided into two groups: DLPFC (30 aMCI; 30 PD-MCI) and LPC (30 aMCI, 30 PD-MCI) for tDCS stimulation. Secondly, they will classify randomly (2:1) real and sham groups for tDCS applied to once a day for 10 days over 2 weeks. The stimulation will be delivered with a 2-mA current frequency and will last 20 min. The primary outcome assessment for this study will be the change in score from baseline to the end of (14-days and 90 days follow-up) the tDCS application for the neurocognitive tests. Potential outcome parameters will be discussed in the light of current literature to contribute to the new area of personalized non-invasive brain stimulation research in neurodegenerative diseases at early stages. The results of this study are expected to shed light on the neural underpinnings and pro-cognitive outcomes of tDCS. Potential outcome parameters will be discussed in the light of current literature to contribute to the new area of personalized non-invasive brain stimulation research in neurodegenerative diseases at early stages.
dc.identifier.doi10.3389/fnhum.2025.1661790
dc.identifier.issn1662-5161
dc.identifier.pmid41293481
dc.identifier.scopus2-s2.0-105022798536
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3389/fnhum.2025.1661790
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5384
dc.identifier.volume19
dc.identifier.wosWOS:001621762500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers in Human Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjecttDCS
dc.subjectparietal memory network
dc.subjectmild cognitive impairment
dc.subjectAlzheimer's disease
dc.subjectParkinson's disease
dc.titleTargeting the parietal memory network with tDCS in MCI: study protocol for a randomized controlled trial
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu