The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder

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dc.authorid0000-0002-3047-3613
dc.authorid0000-0002-2306-5937
dc.authorid0000-0002-9704-6173
dc.contributor.authorYulug, Burak
dc.contributor.authorAyyildiz, Sevilay
dc.contributor.authorSayman, Dila
dc.contributor.authorKaraca, Ramazan
dc.contributor.authorIpek, Lutfiye
dc.contributor.authorCankaya, Seyda
dc.contributor.authorSalar, Ali Behram
dc.date.accessioned2026-01-24T12:30:51Z
dc.date.available2026-01-24T12:30:51Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractINTRODUCTIONEmotionally driven cognitive complaints represent a major diagnostic challenge for clinicians and indicate the importance of objective confirmation of the accuracy of depressive patients' descriptions of their cognitive symptoms.METHODSWe compared cognitive status and structural and functional brain connectivity changes in the pulvinar and hippocampus between patients with total depression and healthy controls. The depressive group was also classified as amnestic or nonamnestic, based on the members' subjective reports concerning their forgetfulness. We then sought to determine whether these patients would differ in terms of objective neuroimaging and cognitive findings.RESULTSThe right pulvinar exhibited altered connectivity in individuals with depression with objective cognitive impairment, a finding which was not apparent in depressive patients with subjective cognitive impairment.DISCUSSIONThe pulvinar may play a role in depression-related cognitive impairments. Connectivity network changes may differ between objective and subjective cognitive impairment in depression and may play a role in the increased risk of dementia in patients with depression.
dc.identifier.doi10.1002/trc2.12450
dc.identifier.issn2352-8737
dc.identifier.issue1
dc.identifier.pmid38356480
dc.identifier.scopus2-s2.0-85184501573
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/trc2.12450
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5488
dc.identifier.volume10
dc.identifier.wosWOS:001159624900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAlzheimers & Dementia-Translational Research & Clinical Interventions
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectamnestic depression
dc.subjectcognition
dc.subjectdepression
dc.subjectfunctional magnetic resonance imaging
dc.subjectpulvinar
dc.titleThe functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder
dc.typeArticle

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