Neuroimaging-Guided Transcranial Magnetic and Direct Current Stimulation in MCI: Toward an Individual, Effective and Disease-Modifying Treatment

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dc.authorid0000-0001-5517-4735
dc.authorid0000-0002-9704-6173
dc.authorid0000-0002-2306-5937
dc.contributor.authorHanoglu, Lutfu
dc.contributor.authorVelioglu, Halil Aziz
dc.contributor.authorHanoglu, Taha
dc.contributor.authorYulug, Burak
dc.date.accessioned2026-01-24T12:29:09Z
dc.date.available2026-01-24T12:29:09Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractThe therapeutic approaches currently applied in Alzheimer's disease (AD) and similar neurodegenerative diseases are essentially based on pharmacological strategies. However, despite intensive research, the effectiveness of these treatments is limited to transient symptomatic effects, and they are still far from exhibiting a true therapeutic effect capable of altering prognosis. The lack of success of such pharmacotherapy-based protocols may be derived from the cases in the majority of trials being too advanced to benefit significantly in therapeutic terms at the clinical level. For neurodegenerative diseases, mild cognitive impairment (MCI) may be an early stage of the disease continuum, including Alzheimer's. Noninvasive brain stimulation (NIBS) techniques have been developed to modulate plasticity in the human cortex in the last few decades. NIBS techniques have made it possible to obtain unique findings concerning brain functions, and design novel approaches to treat various neurological and psychiatric conditions. In addition, its synaptic and cellular neurobiological effects, NIBS is an attractive treatment option in the early phases of neurodegenerative diseases, such as MCI, with its beneficial modifying effects on cellular neuroplasticity. However, there is still insufficient evidence about the potential positive clinical effects of NIBS on MCI. Furthermore, the huge variability of the clinical effects of NIBS limits its use. In this article, we reviewed the combinatory approach of NIBS with various neuroimaging and electrophysiological methods. Such methodologies may provide a new horizon to the path for personalized treatment, including a more individualized pathophysiology approach which might even define new specific targets for specific symptoms of neurodegenerations.
dc.identifier.doi10.1177/15500594211052815
dc.identifier.endpage90
dc.identifier.issn1550-0594
dc.identifier.issn2169-5202
dc.identifier.issue1
dc.identifier.pmid34751037
dc.identifier.scopus2-s2.0-85119118833
dc.identifier.scopusqualityQ2
dc.identifier.startpage82
dc.identifier.urihttps://doi.org/10.1177/15500594211052815
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5145
dc.identifier.volume54
dc.identifier.wosWOS:000717188900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofClinical Eeg and Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectMCI
dc.subjecttranscranial magnetic stimulation (TMS)
dc.subjecttranscranial direct current stimulation (tDCS)
dc.subjectneuroimaging
dc.subjectelectrophysiology
dc.titleNeuroimaging-Guided Transcranial Magnetic and Direct Current Stimulation in MCI: Toward an Individual, Effective and Disease-Modifying Treatment
dc.typeArticle

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