Association between empirically driven dietary patterns and cardiometabolic disease risk factors: a cross-sectional analysis in disease-free adults

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dc.authorid0000-0001-6699-0623
dc.contributor.authorYilmaz, Arife
dc.contributor.authorWeech, Michelle
dc.contributor.authorBountziouka, Vasiliki
dc.contributor.authorJackson, Kim G.
dc.contributor.authorLovegrove, Julie A.
dc.date.accessioned2026-01-24T12:29:10Z
dc.date.available2026-01-24T12:29:10Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBackground Although links between dietary patterns (DPs) and cardiometabolic disease (CMD) risk markers have been identified in UK populations, these studies often rely on less quantitative measures of dietary assessment and include only a limited number of risk markers. Objective This cross-sectional analysis aimed to identify DP in self-reported disease-free adults using weighed diet diaries and explore relationships with a broad range of CMD risk factors and diet quality. Methods Data were collated from five studies conducted in adults living in the UK (2009-2019) and DPs were a posteriori extracted from habitual dietary intake data using principal component analysis. Associations between quartiles (Q) of adherence to the DPs with CMD risk markers, nutrient intakes and the Alternative Healthy Eating Index (AHEI-2010) were evaluated using ANCOVA. Results In our cohort [n = 646, 58.4% female, mean (SD) age 44 (14) years, and body mass index (BMI) 25.2 (4.0) kg/m(2)] two DPs explained 12% of the variance in habitual food intake. Highest adherence to DP1 (Q4), characterised by diets rich in fermented dairy, fruits, vegetables, wholegrains, nuts/seeds, unsaturated fats/oils and milk and lower in red meat dishes and processed meat, was associated with a lower BMI, waist circumference, diastolic blood pressure, fasting triacylglycerol, non-high-density lipoprotein-cholesterol, remnant-like particle-cholesterol, and total cholesterol:HDL-C ratio and a higher HDL-C and AHEI-2010 score versus Q1 (all P <= 0.006). In contrast, Q4 vs Q1 of DP2, high in refined carbohydrates, milk and unsaturated fats/oils and low in cruciferous vegetables/spinach, and nuts/seeds, was only associated with a lower HDL-C (P = 0.006) and AHEI-2010 score (P < 0.001). Conclusions In disease-free adults, greater adherence to DP1, which broadly aligned with UK food-based dietary guidelines, was favourably associated with diet quality and CMD risk markers. Our findings could contribute to the evidence base for future food-based dietary recommendations, particularly highlighting the importance of fermented dairy foods.
dc.description.sponsorshipMilli Egbreve;itim Bakanligbreve;i
dc.description.sponsorshipThe authors would also like to thank Laury Sellem, Roisin Cullen and Celine Kerr for reviewing the categorised datasets and the researchers involved in the primary data collection from the DIVAS (Katerina Vafeiadou, Susan Todd, Parveen Yaqoob), DIVAS-2 (Kumari Rathnayake), RESET (Oonagh Markey, Dafni Vasilopoulou, Colette Fagan, Alistair Grandison, David Humphries, Ian Givens), SATgen epsilon (Andrew Carvalho-Wells, Stacey Lockyer, Anne-Marie Minihane) and BODYCON studies (Ezgi Ozen, Samantha Kinsella, Rada Mihaylova).
dc.identifier.doi10.1186/s12986-025-00965-6
dc.identifier.issn1743-7075
dc.identifier.issue1
dc.identifier.pmid40634995
dc.identifier.scopus2-s2.0-105010336410
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1186/s12986-025-00965-6
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5170
dc.identifier.volume22
dc.identifier.wosWOS:001526467800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmc
dc.relation.ispartofNutrition & Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectAnthropometrics
dc.subjectA posteriori analysis
dc.subjectDiet quality
dc.subjectLipid profile
dc.subjectNutrient intake
dc.subjectPrincipal component analysis
dc.titleAssociation between empirically driven dietary patterns and cardiometabolic disease risk factors: a cross-sectional analysis in disease-free adults
dc.typeArticle

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