Investigation of the effects of astaxanthin in experimental polycystic ovary syndrome (PCOS) in rats

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dc.contributor.authorToktay, Erdem
dc.contributor.authorSelli, Jale
dc.contributor.authorGurbuz, Muhammet Ali
dc.contributor.authorAlaca, Raziye
dc.date.accessioned2026-01-24T12:29:20Z
dc.date.available2026-01-24T12:29:20Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjective(s): The aim of this study was to investigate the effect of Astaxanthin (ASX) on ovaries in letrozole-induced polycystic ovary syndrome (PCOS) model in female rats by histopathological, immunohistochemical and biochemical techniques.Materials and Methods: Seventy two Sprague-Dawley female rats with an average weight of 200-250 gr and 10-12 weeks old were randomly divided into 9 groups. PCOS model was applied to all groups except healthy group. In the study, low (10 mg / kg) moderate (20 mg / kg) and high (40 mg / kg) doses of ASX were given to the experimental animals in the PCOS-induced groups for 7 days. At the end of the experiment, ovarian tissues were evaluated histopathologically, immunohistochemically, and biochemically. Results: When the histopathological findings were examined, many cystic follicles, apoptotic and necrotic cells were found in the follicles in the PCOS group. In addition, significant decrease in apoptotic and necrotic cells were observed in PCOS+MET+ASX and PCOS+ASX groups. In immunohistochemical staining findings, while TNF-alpha, NF-KB and IL-6 expression levels showed significant increase in PCOS group, these expression levels were decreased in PCOS+MET+ASX and PCOS+ASX groups. In the biochemical evaluations, while MDA were increased, SOD were decreased in the PCOS group. MDA level were decreased while SOD levels were increased in the PCOS+MET+ASX and PCOS+ASX groups.Conclusion: In addition to the formation of insulin resistance in the tissue, severe oxidative stress damage occurs in ovarian tissue during PCOS. Metformin improved PCOS by correcting insulin resistance. In this period, the administration of ASX with Metformin protected the ovary from oxidative stress damage
dc.description.sponsorshipxxx University; [TSA-2019-7153]
dc.description.sponsorshipThis study was supported by xxx University as a scientific research project numbered TSA-2019-7153.
dc.identifier.doi10.22038/IJBMS.2023.69984.15223
dc.identifier.endpage1161
dc.identifier.issn2008-3866
dc.identifier.issn2008-3874
dc.identifier.issue10
dc.identifier.pmid37736515
dc.identifier.scopus2-s2.0-85179105100
dc.identifier.scopusqualityQ2
dc.identifier.startpage1155
dc.identifier.urihttps://doi.org/10.22038/IJBMS.2023.69984.15223
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5294
dc.identifier.volume26
dc.identifier.wosWOS:001124240800008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMashhad Univ Med Sciences
dc.relation.ispartofIranian Journal of Basic Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectAstaxanthin
dc.subjectMetformin
dc.subjectOvary
dc.subjectOxidative stress
dc.subjectPolycystic ovary syndrome
dc.titleInvestigation of the effects of astaxanthin in experimental polycystic ovary syndrome (PCOS) in rats
dc.typeArticle

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