Exosomes: A missing link between chronic systemic inflammation and Alzheimer's disease?

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dc.authorid0000-0002-1079-8832
dc.authorid0000-0002-2306-5937
dc.contributor.authorOzansoy, Mehmet
dc.contributor.authorMikati, Houda
dc.contributor.authorVelioglu, Halil Aziz
dc.contributor.authorYulug, Burak
dc.date.accessioned2026-01-24T12:31:07Z
dc.date.available2026-01-24T12:31:07Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractExosomes are potent mediators of physiological and pathological processes. In Alzheimer's disease and in-flammatory disorders, due to exosomes' distinctive ability to cross the blood-brain barrier, a bidirectional communication between the periphery and the central nervous system exists. Since exosomes can carry various biochemical molecules, this review investigates the role of exosomes as possible mediators between chronic systemic inflammatory diseases and Alzheimer's disease. Exosomes carry pro-inflammatory molecules generated in the periphery, travel to the central nervous system, and target glial and neuronal cells. Microglia and astro-cytes then become activated, initiating chronic neuroinflammation. As the aging brain is more susceptible to such changes, this state of neuroinflammation can stimulate neuropathologies, impair amyloid-beta clearance capa-bilities, and generate dysregulated microRNAs that alter the expression of genes critical in Alzheimer's disease pathology. These processes, individually and collectively, become significant risk factors for the development of Alzheimer's disease.
dc.identifier.doi10.1016/j.biopha.2022.114161
dc.identifier.issn0753-3322
dc.identifier.issn1950-6007
dc.identifier.pmid36641928
dc.identifier.scopus2-s2.0-85146188932
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2022.114161
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5650
dc.identifier.volume159
dc.identifier.wosWOS:000923764200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier
dc.relation.ispartofBiomedicine & Pharmacotherapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectSystemic chronic inflammatory diseases
dc.subjectNeurodegenerative diseases
dc.subjectAlzheimer?s disease
dc.subjectExosomes
dc.subjectExtracellular vesicles
dc.titleExosomes: A missing link between chronic systemic inflammation and Alzheimer's disease?
dc.typeReview Article

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