FDG-PET scanning shows distributed changes in cortical activity associated with visual hallucinations in eye disease

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dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorYıldız, Sultan
dc.contributor.authorÇakır, Tansel
dc.contributor.authorHanoğlu, Taha
dc.contributor.authorYuluğ, Burak
dc.date.accessioned2021-02-19T21:16:48Z
dc.date.available2021-02-19T21:16:48Z
dc.date.issued2019
dc.departmentALKÜ
dc.description.abstractBackground and Objective: Charles Bonnet Syndrome (CBS) has been defined as complex visual hallucinations (CVH) due to visual loss. The underlying mechanism of CBS is not clear and the underlying pathophysiology of the visual hallucinations in CBS patients and pure visually impaired patients is still not clear. Methods: In our study, we have scanned three patients with eye disease and CBS (VH+) and three patients with eye disease without CBS (VH-) using FDG-PET. Results: Our results showed underactivity in the pons and overactivity in primary right left visual cortex and inferior parietal cortex in VH- patients and underactivity in left Broca, left inf frontal primary visual cortex and anterior and posterior cingulate cortex in VH+ patients relative to the normative 18F-FDG PET data that was taken from the database consisting of 50 age-matched healthy adults without neuropsychiatric disorders. Conclusion: From this distributed pattern of activity changes, we conclude that the generation of visual hallucination in CBS is associated with bottom-up and top-down mechanism rather than the generally accepted visual deafferentation-related hyperexcitability theory.
dc.identifier.doi10.2174/1871530318666180830112709
dc.identifier.endpage89en_US
dc.identifier.issn1871-5303
dc.identifier.issn2212-3873
dc.identifier.issue1en_US
dc.identifier.pmid30160221
dc.identifier.scopusqualityQ2
dc.identifier.startpage84en_US
dc.identifier.urihttps://doi.org/10.2174/1871530318666180830112709
dc.identifier.urihttps://hdl.handle.net/20.500.12868/557
dc.identifier.volume19en_US
dc.identifier.wosWOS:000458024300011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofEndocrine Metabolic & Immune Disorders-Drug Targets
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectVisual hallucination
dc.subjectcharles bonnet syndrome
dc.subject18F-FDG PET scanning
dc.subjectvisual deafferentation theory
dc.subjectglaucoma
dc.subjectage-related macular degeneration
dc.subjectdiabetic retinopathy
dc.titleFDG-PET scanning shows distributed changes in cortical activity associated with visual hallucinations in eye disease
dc.typeArticle

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