Transcranial direct current stimulation alleviates nociceptive behavior in male rats with neuropathic pain by regulating oxidative stress and reducing neuroinflammation

Basit Öğe Kaydı
dc.authorid0000-0003-3418-8825
dc.contributor.authorAkcay, Guven
dc.contributor.authorSamur, Dilara Nemutlu
dc.contributor.authorDerin, Narin
dc.date.accessioned2026-01-24T12:30:50Z
dc.date.available2026-01-24T12:30:50Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractTranscranial direct curent stimulation (tDCS) and trans--spinal direct current stimulation (tsDCS) are promising therapies for pain that can alter the excitability of neuronal activity in cerebral cortex. The aim of the study is to investigate the therapeutic effects of direct current stimulation (DCS) over the spinal cord and cerebral cortex on oxidative stress and neuroinflammation in rats with chronic constriction injury (CCI). Male Wistar rats were randomly divided into four experimental groups: Sham, CCI, CCI + tDCS and CCI + tsDCS. The neuropathic pain model was induced by using the CCI model. Rats with neuropathy were treated with cathodal tDCS and tsDCS stimulations consisting of 0.5 mA for 30 min a day for 7 days from day 8 onwards. Locomotor activity was measured by open--field test and nociceptive behavior was assessed by hot--plate, tail--flick and Randall--Selitto tests. Following the behavioral experiments, total oxidant capacity ( TOC), total antioxidant capacity (TAC) and proinflammatory cytokine levels were evaluated in spinal cord and cerebral cortex tissues. The CCI model induced significant mechanical and thermal hyperalgesia. Nociceptive behaviors in rats with CCI were reversed by DCS treatment. Higher TOC and lower TAC levels were detected in the spinal cord and cerebral cortex tissues of the CCI rats compared to the control. tsDCS treatment amended oxidant/antioxidant status. Moreover, tsDCS modulated the central levels of Tumor necrosis factor--a (TNF--a), interleukin 1--beta (IL--1 ss), IL- -6 and IL--18. tsDCS stimulation showed better therapeutic effect on neuropathic pain by regulating oxidant/antioxidant levels and reducing neuroinflammation. DCS, especially at spinal level, may be a promising therapeutic strategy that can be used alone or in combination with other effective treatments for alleviating neuropathic pain.
dc.description.sponsorshipHitit Universitesi; Coordination Unit of Scientific Research Projects of Hitit University [TIP19001.22.001]
dc.description.sponsorshipHitit UniversitesiThis work was supported by Coordination Unit of Scientific Research Projects of Hitit University (Project number: TIP19001.22.001)
dc.identifier.doi10.1002/jnr.25204
dc.identifier.endpage1470
dc.identifier.issn0360-4012
dc.identifier.issn1097-4547
dc.identifier.issue9
dc.identifier.pmid37313582
dc.identifier.scopus2-s2.0-85163052725
dc.identifier.scopusqualityQ1
dc.identifier.startpage1457
dc.identifier.urihttps://doi.org/10.1002/jnr.25204
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5462
dc.identifier.volume101
dc.identifier.wosWOS:001008917500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Neuroscience Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectchronic constriction injury
dc.subjectneuroinflammation
dc.subjectneuropathic pain
dc.subjecttDCS
dc.titleTranscranial direct current stimulation alleviates nociceptive behavior in male rats with neuropathic pain by regulating oxidative stress and reducing neuroinflammation
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu