Neuroendocrine modulation by metamizole and indomethacin: investigating the impact on neuronal markers and GnRH release

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dc.authorid0000-0001-5284-7439
dc.contributor.authorMaytalman, Erkan
dc.contributor.authorSamur, Dilara Nemutlu
dc.date.accessioned2026-01-24T12:30:59Z
dc.date.available2026-01-24T12:30:59Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractPurposeSome evidence that non-steroidal anti-inflammatory drugs have neuroprotective effects indicates their potential for use in a new field. However, their effects on hormone secretion have yet to be adequately discovered. Therefore, we aimed to evaluate the effects of metamizole and indomethacin on neuronal markers as well as the GnRH expression in the GT1-7 cell line.MethodsThe effects of these drugs on proliferation were evaluated by MTT analysis. The effect of 10-50-250 mu M concentrations of the drugs also on the expression of neuronal factors and markers, including NGF, nestin and beta III Tubulin, and additionally GnRH, was determined by the RT-qPCR method.ResultsNGF and nestin mRNA expressions were increased in all concentrations of both metamizole and indomethacin. No changes were detected in beta III Tubulin. While metamizole showed an increase in GnRH mRNA expression, there was no change at 10 and 50 mu M concentrations of indomethacin, but a remarkable decrease was observed at 250 mu M concentrations.ConclusionsThe results of our study showing an increase in the expression of neuronal factors reveal that metamizole and indomethacin may have possible neuroprotective effects. Moreover, the effects on the GnRH expression appear to be different. Animal models are required to confirm these effects of NSAIDs on neurons.
dc.description.sponsorshipAlanya Alaaddin Keykubat University Scientific Research Projects Unit [2020-04-02-MAP01]
dc.description.sponsorshipThis study was supported by Alanya Alaaddin Keykubat University Scientific Research Projects Unit. Project ID: 2020-04-02-MAP01.
dc.identifier.doi10.1007/s12020-024-03822-3
dc.identifier.endpage1336
dc.identifier.issn1355-008X
dc.identifier.issn1559-0100
dc.identifier.issue3
dc.identifier.pmid38625503
dc.identifier.scopus2-s2.0-85190532301
dc.identifier.scopusqualityQ2
dc.identifier.startpage1327
dc.identifier.urihttps://doi.org/10.1007/s12020-024-03822-3
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5575
dc.identifier.volume85
dc.identifier.wosWOS:001289493800031
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofEndocrine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectMetamizole
dc.subjectIndomethacin
dc.subjectGT1-7 cell line
dc.subjectNeuronal markers
dc.subjectGnRH
dc.titleNeuroendocrine modulation by metamizole and indomethacin: investigating the impact on neuronal markers and GnRH release
dc.typeArticle

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