Plasma thiol/disulphide homeostasis changes in patients with restless legs syndrome

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dc.authorid0000-0003-0469-0064
dc.authorid0000-0002-1413-4523
dc.authorid0000-0002-0974-5717
dc.contributor.authorKucuksayan, Ertan
dc.contributor.authorOzben, Serkan
dc.contributor.authorTuac, Selma Topaloglu
dc.contributor.authorKoseoglu, Mesrure
dc.contributor.authorErel, Ozcan
dc.contributor.authorNeselioglu, Salim
dc.contributor.authorOzben, Tomris
dc.date.accessioned2026-01-24T12:29:13Z
dc.date.available2026-01-24T12:29:13Z
dc.date.issued2021
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjectives: Restless legs syndrome (RLS) is a common neurological condition. Oxidative stress plays an important role in its pathogenesis. Thiol-disulphide homeostasis (TDH) is a new biomarker of oxidative stress. We studied plasma TDH to determine whether TDH could be used as a new biomarker for RLS and evaluated correlations between TDH and various disease severity rating scales. Methods: A total of 25 RLS patients and 25 healthy controls were included into the study. TDH status was determined using an automated spectrophotometric analysis method and correlations were analyzed between the TDH status and various disease rating scales in the RLS patients. Results: Plasma total (401 +/- 27 mu mol/L) and native thiol (354 +/- 30 mu mol/L) levels were significantly lower, but disulphide level (24 +/- 6 itmol/L) was significantly (<0.0001) higher in the RLS patients compared to the controls (455 +/- 36, 424 +/- 37, 15 +/- 5 mu mol/L, respectively). The disulphide/native thiol and disulphide/total thiol ratios increased, in contrast, native thiol/total thiol ratio decreased significantly in the RLS patients compared to the healthy controls (<0.0001). The disulphide levels correlated positively with age and various rating scores of the RLS patients. International Restless Legs Syndrome Study Group (IRL SSG) rating score and age correlated negatively with the total and native thiol levels. Conclusions: Our findings indicate increased oxidative stress in the RLS patients reflected by decreased native and total thiol, and increased disulphide levels and positive correlations between the disulphide levels and various rating scores. We suggest dynamic TDH status to be used as a novel biomarker for the diagnosis and follow-up of the RLS patients.
dc.identifier.doi10.1515/cclm-2020-1659
dc.identifier.endpage1265
dc.identifier.issn1434-6621
dc.identifier.issn1437-4331
dc.identifier.issue7
dc.identifier.pmid33675215
dc.identifier.scopus2-s2.0-85102286951
dc.identifier.scopusqualityQ1
dc.identifier.startpage1257
dc.identifier.urihttps://doi.org/10.1515/cclm-2020-1659
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5213
dc.identifier.volume59
dc.identifier.wosWOS:000663327700020
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofClinical Chemistry and Laboratory Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectdisulphide
dc.subjectnative thiol
dc.subjectoxidative stress
dc.subjectrestless legs syndrome
dc.subjectthiol disulphide homeostasis
dc.subjecttotal thiol
dc.titlePlasma thiol/disulphide homeostasis changes in patients with restless legs syndrome
dc.typeArticle

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