Relationship between polycystic ovary syndrome and high periostin level

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dc.authorid0000-0002-9959-9433
dc.contributor.authorEroglu, Semra
dc.contributor.authorCakmakliogullari, Elcin Kal
dc.date.accessioned2026-01-24T12:29:17Z
dc.date.available2026-01-24T12:29:17Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractOBJECTIVE: There is growing evidence suggesting a relationship between periostin levels, inflammation, and ovarian dysfunction. In this prospective case-control study, we aimed to investigate serum periostin levels and their relationship with metabolic parameters in patients with polycystic ovary syndrome. METHODS: We conducted a prospective case-control study involving 45 polycystic ovary syndrome patients and 45 control subjects, matched in a 1:1 ratio. Serum samples collected from both study and control groups were analyzed using enzyme-linked immunosorbent assay. RESULTS: The demographic characteristics were similar between the polycystic ovary syndrome and control groups (p>0.05). Periostin levels were significantly higher in patients with polycystic ovary syndrome compared with the control group (4.67 +/- 2.46 vs. 2.60 +/- 1.41 ng/mL, respectively; p=0.000). CONCLUSION: Our study revealed a significant elevation in periostin levels among polycystic ovary syndrome patients compared with controls. These findings suggest that periostin could serve as a potential marker for assessing disease severity in polycystic ovary syndrome patients.
dc.description.sponsorshipKarabuk University [17-KP-348]
dc.description.sponsorshipAcknowledgments This work was supported by Karabuk University under Grant number 17-KP-348.
dc.identifier.doi10.1590/1806-9282.20240138
dc.identifier.issn0104-4230
dc.identifier.issn1806-9282
dc.identifier.issue6
dc.identifier.pmid39045965
dc.identifier.scopus2-s2.0-85199376165
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1590/1806-9282.20240138
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5238
dc.identifier.volume70
dc.identifier.wosWOS:001276106600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAssoc Medica Brasileira
dc.relation.ispartofRevista Da Associacao Medica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectPolycystic ovary syndrome
dc.subjectPeriostin
dc.subjectInflammation
dc.subjectInsulin resistance
dc.titleRelationship between polycystic ovary syndrome and high periostin level
dc.typeArticle

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